{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified critical regulators of cell survival and stress responses. In murine models exposed to ionizing radiation, an active recombinant human MnSOD was shown to protect normal tissues and, at the same time, sensitize tumor cells by activating antiapoptotic factors such as AVEN, while studies in the mouse testis have revealed alternative transcript variants of the AVEN gene linked to germ cell maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate context, myocardial infarction has been associated with global 3′ untranslated region lengthening of key genes. Notably, alternative polyadenylation of the apoptotic repressor gene AVEN generates additional microRNA binding sites that lead to its downregulation, thereby exacerbating cardiomyocyte apoptosis and contributing to heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct from these regulatory mechanisms, the long noncoding RNA TLX1NB—located adjacent to the T cell leukemia homeobox 1 gene—has emerged as an oncogenic driver in colorectal cancer. TLX1NB is markedly up‐regulated in colon cancer tissues and correlates with advanced nodal stages. Functional experiments demonstrated that overexpression of TLX1NB enhances colon cancer cell migration, invasion, and pulmonary metastasis by promoting STAT5A phosphorylation, concurrently modulating epithelial and mesenchymal marker expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonella Borrelli, Antonella Schiattarella, Roberto Mancini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2008.10.030"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2008.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18996183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18996183"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sawako Ina, Naoki Tsunekawa, Aya Nakamura, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of apoptotic repressor "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "AVEN"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " exacerbates cardiac injury after myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2302482120"}], "href": "https://doi.org/10.1073/pnas.2302482120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37816050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37816050"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guanyang Chen, Dongbo Lian, Lei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2068781"}], "href": "https://doi.org/10.1080/21655979.2022.2068781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35502613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35502613"}]}]}]}