{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the 37 abstracts directly investigate TMEFF2, they collectively offer a detailed picture of how cells control life‐and‐death decisions through pathways regulated by caspase‑8 and its associated partners. In these studies, caspase‑8 is shown to act as a molecular switch that not only triggers extrinsic apoptosis but also regulates non‐apoptotic modes of cell death—such as necroptosis and pyroptosis—by interacting with key proteins like receptor‐interacting kinases (RIPK1 and RIPK3), MLKL, and several inflammasome components. These reports describe how caspase‑8 complexes with adaptor proteins (for example, FADD) and other signaling mediators to balance inflammatory responses, tissue homeostasis, and immune defense under stress or pathogenic insults."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports in the set further emphasize the formation of caspase‑8–containing complexes that integrate signals from death receptors, pattern recognition receptors, and other stress stimuli to orchestrate apoptosis, necroptosis, and activation of inflammasomes. In diverse settings—including intestinal epithelial injury, liver apoptosis, and lymphocyte activation—these studies reveal that the precise assembly and regulation of multiprotein complexes (involving caspase‑8, FADD, RIP kinases, and additional mediators) is essential for restricting unwanted cell death and inflammation while promoting appropriate immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these abstracts do not address TMEFF2 directly, they map out a complex regulatory landscape of cell death and inflammatory signaling that may provide indirect clues about where a transmembrane protein—such as TMEFF2, known from other studies to harbor EGF‑like and follistatin‑like domains and to potentially modulate cell proliferation and survival—could function. It is conceivable that TMEFF2 might interact with or influence such cascades, perhaps affecting the balance between apoptotic and non‐apoptotic death pathways. However, dedicated studies will be needed to define whether and how TMEFF2 interfaces with these critical caspase‑8–regulated mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Jimbo, E Fujita, Y Kouroku, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-4827(02)00033-2"}], "href": "https://doi.org/10.1016/s0014-4827(02"}, {"type": "t", "text": "00033-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12581736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12581736"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Won-Seok Choi, Dae-Seok Eom, Baek S Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311164200"}], "href": "https://doi.org/10.1074/jbc.M311164200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14993216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14993216"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Yu, Ajjai Alva, Helen Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1096645"}], "href": "https://doi.org/10.1126/science.1096645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15131264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15131264"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Helen Su, Nicolas Bidère, Lixin Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for caspase-8 in NF-kappaB activation by antigen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1104765"}], "href": "https://doi.org/10.1126/science.1104765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15746428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15746428"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Karsten Schulmann, Anca Sterian, Agnes Berki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208598"}], "href": "https://doi.org/10.1038/sj.onc.1208598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15824739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15824739"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daniel R Beisner, Irene L Ch'en, Ravi V Kolla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: innate immunity conferred by B cells is regulated by caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.175.6.3469"}], "href": "https://doi.org/10.4049/jimmunol.175.6.3469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16148088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16148088"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dwayne G Stupack, Tal Teitz, Matthew D Potter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potentiation of neuroblastoma metastasis by loss of caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04323"}], "href": "https://doi.org/10.1038/nature04323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16397500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16397500"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ken Takahashi, Taro Kawai, Himanshu Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.176.8.4520"}], "href": "https://doi.org/10.4049/jimmunol.176.8.4520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16585540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16585540"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bénédicte Lemmers, Leonardo Salmena, Nicolas Bidère, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M606721200"}], "href": "https://doi.org/10.1074/jbc.M606721200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213198"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sébastien Conus, Remo Perozzo, Thomas Reinheckel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20072152"}], "href": "https://doi.org/10.1084/jem.20072152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18299403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18299403"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jonathan Maelfait, Elisabeth Vercammen, Sophie Janssens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20071632"}], "href": "https://doi.org/10.1084/jem.20071632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18725521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18725521"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bryan D Bell, Sabrina Leverrier, Brian M Weist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0808597105"}], "href": "https://doi.org/10.1073/pnas.0808597105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18946037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18946037"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thomas Kaufmann, Philipp J Jost, Marc Pellegrini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2008.10.017"}], "href": "https://doi.org/10.1016/j.immuni.2008.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19119023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19119023"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Pedro Lee, Dai-Jen Lee, Carol Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic expression of epidermal caspase 8 simulates a wound healing response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07687"}], "href": "https://doi.org/10.1038/nature07687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19204729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19204729"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Andrew Kovalenko, Jin-Chul Kim, Tae-Bong Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20090616"}], "href": "https://doi.org/10.1084/jem.20090616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19720838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19720838"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Vera L Costa, Rui Henrique, Stine A Danielsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-1312"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-1312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20975101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20975101"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hua Li, Peng Wang, Quanhong Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-4475"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-4475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21444671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21444671"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Claudia Günther, Eva Martini, Nadine Wittkopf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10400"}], "href": "https://doi.org/10.1038/nature10400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21921917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21921917"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Edward S Mocarski, Jason W Upton, William J Kaiser "}, {"type": "b", "children": [{"type": "t", "text": "Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nri3131"}], "href": "https://doi.org/10.1038/nri3131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22193709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22193709"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Megan M Young, Yoshinori Takahashi, Osman Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.309104"}], "href": "https://doi.org/10.1074/jbc.M111.309104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22362782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22362782"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Christopher P Dillon, Andrew Oberst, Ricardo Weinlich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Survival function of the FADD-CASPASE-8-cFLIP(L) complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2012.03.010"}], "href": "https://doi.org/10.1016/j.celrep.2012.03.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22675671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22675671"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Tae-Bong Kang, Seung-Hoon Yang, Beata Toth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.09.015"}], "href": "https://doi.org/10.1016/j.immuni.2012.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23260196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23260196"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "V Sagulenko, S J Thygesen, D P Sester, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2013.37"}], "href": "https://doi.org/10.1038/cdd.2013.37"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23645208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23645208"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Si Ming Man, Panagiotis Tourlomousis, Lee Hopkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1301581"}], "href": "https://doi.org/10.4049/jimmunol.1301581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24123685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24123685"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Prajwal Gurung, Paras K Anand, R K Subbarao Malireddi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1302839"}], "href": "https://doi.org/10.4049/jimmunol.1302839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24453255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24453255"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Dan Weng, Robyn Marty-Roix, Sandhya Ganesan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1403477111"}], "href": "https://doi.org/10.1073/pnas.1403477111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24799678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24799678"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Naomi H Philip, Christopher P Dillon, Annelise G Snyder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1403252111"}], "href": "https://doi.org/10.1073/pnas.1403252111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24799700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24799700"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wei Chi, Fei Li, Hongrui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1402819111"}], "href": "https://doi.org/10.1073/pnas.1402819111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25024200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25024200"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Kenta Moriwaki, John Bertin, Peter J Gough, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1402167"}], "href": "https://doi.org/10.4049/jimmunol.1402167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25567679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25567679"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Prajwal Gurung, Bofeng Li, R K Subbarao Malireddi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep14488"}], "href": "https://doi.org/10.1038/srep14488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26412089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26412089"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yannick Boege, Mohsen Malehmir, Marc E Healy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2017.08.010"}], "href": "https://doi.org/10.1016/j.ccell.2017.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28898696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28898696"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Pontus Orning, Dan Weng, Kristian Starheim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aau2818"}], "href": "https://doi.org/10.1126/science.aau2818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30361383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30361383"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Joseph Sarhan, Beiyun C Liu, Hayley I Muendlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Yersinia"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1809548115"}], "href": "https://doi.org/10.1073/pnas.1809548115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30381458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30381458"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Kim Newton, Katherine E Wickliffe, Allie Maltzman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity of caspase-8 determines plasticity between cell death pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-019-1752-8"}], "href": "https://doi.org/10.1038/s41586-019-1752-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31723262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31723262"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Melanie Fritsch, Saskia D Günther, Robin Schwarzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-019-1770-6"}], "href": "https://doi.org/10.1038/s41586-019-1770-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31748744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31748744"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Jia-Yuan Zhang, Bo Zhou, Ru-Yue Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-021-00506-9"}], "href": "https://doi.org/10.1038/s41422-021-00506-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34012073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34012073"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Zengzhang Zheng, Wanyan Deng, Yang Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Yersinia"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.abg0269"}], "href": "https://doi.org/10.1126/science.abg0269"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35058659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35058659"}]}]}]}