{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence demonstrates that TMEM147‐AS1 contributes to tumor progression by modulating key cellular functions. In prostatic carcinoma, TMEM147‐AS1 has been implicated in the regulation of aerobic glycolysis—an effect intrinsic to the Warburg phenomenon—by enhancing glucose uptake and lactate production, thereby fostering a metabolic environment conducive to rapid tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn gastric cancer, TMEM147‐AS1 is markedly overexpressed and its elevated levels correlate with a poorer prognosis. Functional studies reveal that silencing TMEM147‐AS1 significantly impairs cancer cell proliferation, colony formation, migration, and invasion. Mechanistically, TMEM147‐AS1 acts as a sponge for microRNA‐326, which leads to a subsequent upregulation of SMAD5—a critical effector in driving tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nMoreover, in estrogen receptor–positive breast cancer, TMEM147‐AS1 participates in a regulatory axis involving microRNA‐124 and STAT3. By modulating this miR‐124/STAT3 pathway, TMEM147‐AS1 influences tumor cell behavior and contributes to cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Wu, Niwei Han, Changyong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis regulates the Warburg effect and promotes prostatic carcinoma invasion and proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3453"}], "href": "https://doi.org/10.1002/jgm.3453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36181243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36181243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xufu Qin, Ziye Jiang, Yongcui Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.32604/or.2022.03568"}], "href": "https://doi.org/10.32604/or.2022.03568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37303938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37303938"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Liang, Xuanchang Zhang, Jia Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TMEM147 antisense RNA 1/microRNA-124/signal transducer and activator of transcription 3 axis in estrogen receptor-positive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.16037"}], "href": "https://doi.org/10.1111/jog.16037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39113102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39113102"}]}]}]}