{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough our review was intended to elucidate the function of TMEM218, none of the provided abstracts mention or characterize TMEM218. Instead, the collection of studies predominantly examines complement‐dependent mechanisms—especially those mediated via the C3a and C5a receptors—in regulating immune cell activation, differentiation, trafficking, and effector functions across a broad array of physiological and pathological settings. These include modulation of T‐cell costimulation and regulatory T‐cell induction, the control of neutrophil mobilization and NETosis in tumorigenesis and tissue injury, enhancement of antigen‐presenting cell function, and complex interactions governing inflammatory conditions such as asthma, autoimmune nephritis, and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these articles collectively reveal that complement receptor signaling is a critical regulator of immune responses, inflammation, and tissue homeostasis in diverse contexts, they do not provide any data or functional insights regarding TMEM218. Thus, based solely on the evidence in these abstracts, no function for TMEM218 can be ascribed. This gap in the literature suggests that if TMEM218 plays a role in similar pathways or related cellular processes, its activity remains to be identified by future studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Scott M Drouin, David B Corry, Travis J Hollman, et al. 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