{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies on the long noncoding RNA LINC00675 have revealed a context-dependent role in tumorigenesis. In gastric cancer, colorectal cancer, and pancreatic ductal adenocarcinoma, LINC00675 has been shown to act as a tumor suppressor by inhibiting cellular proliferation, migration, invasion, and metastasis through mechanisms such as interaction with cytoskeletal protein vimentin and attenuation of the Wnt/β‑catenin pathway (thereby modulating miRNAs, e.g. miR‑942). Conversely, in cervical cancer, glioma, muscle‑invasive bladder cancer, and acute myeloid leukemia, upregulation of LINC00675 correlates with advanced tumor stage, poor prognosis, and oncogenic functions, wherein it promotes proliferation and survival by enhancing pro‑tumor signaling pathways and regulating oncoproteins (including TRIP6 and CDK6). In addition, a gastrointestinal‑specific isoform encoding a conserved 79‑amino acid small protein (FORCP) has been identified, which appears to mediate tumor‑suppressive effects in well‑differentiated colorectal cancer cells by inhibiting clonogenicity and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, investigations into the potassium‑dependent sodium/calcium exchanger NCKX3 have underscored its critical roles in calcium homeostasis and cellular physiology. NCKX3 is abundantly expressed in tissues such as the uterus, kidney, and brain, where it facilitates active calcium transport—contributing to uterine function, renal calcium reabsorption, and maintenance of intracellular calcium levels essential for neuronal activity. Hormonal regulation studies have demonstrated that sex steroids and adrenal hormones can modulate NCKX3 expression, while gene ablation models have revealed compensatory shifts in calcium‑handling machinery, alterations in bone mineral content, heightened inflammatory responses in the gut, and behavioral as well as motor learning deficits. Collectively, these findings indicate that NCKX3 is a multifaceted regulator of calcium signaling with broad implications for both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dou-Dou Li, Zhi-Qiang Fu, Qing Lin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.02.123"}], "href": "https://doi.org/10.1016/j.biopha.2018.02.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29524886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29524886"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhibing Li, Yijian Li, Qibai Wang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181039"}], "href": "https://doi.org/10.1042/BSR20181039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30061182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30061182"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shuyun Ma, Xiaohong Deng, Yang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.10.011"}], "href": "https://doi.org/10.1016/j.biopha.2018.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30372871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30372871"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xing Liu, Jingwei Ke, Li Gu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.53734"}], "href": "https://doi.org/10.7554/eLife.53734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33112233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33112233"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gulper Nacarkahya, Ersin Borazan, Cem Horozoglu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2024.155221"}], "href": "https://doi.org/10.1016/j.prp.2024.155221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38422911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38422911"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hyun Yang, Geun-Shik Lee, Yeong-Min Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.05.076"}], "href": "https://doi.org/10.1016/j.bbrc.2009.05.076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19464262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19464262"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Geun-Shik Lee, Kyung-Chul Choi, Eui-Bae Jeung "}, {"type": "b", "children": [{"type": "t", "text": "K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.90615.2008"}], "href": "https://doi.org/10.1152/ajprenal.90615.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19474185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19474185"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hyun Yang, Changhwan Ahn, Eun-Kyeong Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2017.06.006"}], "href": "https://doi.org/10.1016/j.mce.2017.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28602864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28602864"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "D N Tran, E-M Jung, Y-M Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Pharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26402/jpp.2020.4.08"}], "href": "https://doi.org/10.26402/jpp.2020.4.08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33214341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33214341"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dinh Nam Tran, Seon Myeong Go, Seon-Mi Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-κB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22052645"}], "href": "https://doi.org/10.3390/ijms22052645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33807999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33807999"}]}]}]}