Name | TMEM51 antisense RNA 1 |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCalcium‐dependent activator protein for secretion 2 (CAPS2) is a dense‐core vesicle protein that plays a pivotal role in Ca²⁺‐dependent exocytosis of neurotrophic factors and neuropeptides. In neurons of the hippocampus and cerebellum, CAPS2 promotes activity‐dependent release of brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT‐3), a process that is essential for the development and maintenance of inhibitory circuits, proper synaptic formation, and neuronal survival. While other Ca²⁺‐binding proteins such as calcyphosine (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "have been characterized, CAPS2 uniquely orchestrates neurotrophic secretion and synaptic plasticity, with its dysfunction being linked to developmental deficits and autism spectrum disorder–related phenotypes (PMID:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to driving exocytosis at the plasma membrane, CAPS2 plays a critical role in dense‐core vesicle priming and intracellular vesicle trafficking. It is involved in vesicle priming via its pleckstrin homology domain rather than through its MUN domain, distinguishing its mechanism from that of Munc13 proteins. CAPS2 also localizes to the Golgi apparatus, where it recruits GDP‐bound ARF4/ARF5 to promote proper vesicle biogenesis. Moreover, the expression of naturally occurring CAPS2 splice variants—one containing an alternative exon that enhances vesicular monoamine transporter function—modulates catecholamine loading into vesicles, thereby fine‐tuning monoaminergic transmission (PMID:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCAPS2 further influences neuroendocrine signaling and behavior by regulating hormone and neuropeptide release. For example, CAPS2 modulates oxytocin secretion from hypothalamic neurons, impacting social interaction and recognition, while its deficiency also alters endocrine responses—such as insulin and leptin release—that affect stress reactivity, weight regulation, and adult hippocampal neurogenesis. Disruption of CAPS2 function therefore has broad implications, contributing to autistic‐like behaviors, anxiety, and impaired neurogenesis (PMID:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shu Wang, Jin-zhong Chen, Zhen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning, characterization, and expression of calcyphosine 2, a novel human gene encoding an EF-hand Ca(2+)-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.2002.6461"}], "href": "https://doi.org/10.1006/bbrc.2002.6461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11846421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11846421"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tetsushi Sadakata, Teiichi Furuichi "}, {"type": "b", "children": [{"type": "t", "text": "Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cerebellum (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12311-009-0097-5"}], "href": "https://doi.org/10.1007/s12311-009-0097-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19238500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19238500"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tetsushi Sadakata, Teiichi Furuichi "}, {"type": "b", "children": [{"type": "t", "text": "Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neures.2010.03.006"}], "href": "https://doi.org/10.1016/j.neures.2010.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20302894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20302894"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yo Shinoda, Tetsushi Sadakata, Kazuhito Nakao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1012220108"}], "href": "https://doi.org/10.1073/pnas.1012220108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21173225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21173225"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yo Shinoda, Tetsushi Sadakata, Teiichi Furuichi "}, {"type": "b", "children": [{"type": "t", "text": "Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Anim (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1538/expanim.62.71"}], "href": "https://doi.org/10.1538/expanim.62.71"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23615300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23615300"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tetsushi Sadakata, Yukiko Sekine, Megumi Oka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2011.08431.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2011.08431.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22111578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22111578"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cuc Quynh Nguyen Truong, Dennis Nestvogel, Olga Ratai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.09.050"}], "href": "https://doi.org/10.1016/j.celrep.2014.09.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25437547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25437547"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Olga Ratai, Claudia Schirra, Elvin Rajabov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2040-18.2018"}], "href": "https://doi.org/10.1523/JNEUROSCI.2040-18.2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30389842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30389842"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep08932"}], "href": "https://doi.org/10.1038/srep08932"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25754523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25754523"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kaori Yagishita, Ritsuko Suzuki, Shota Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2017.09.047"}], "href": "https://doi.org/10.1016/j.neulet.2017.09.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28963059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28963059"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shuhei Fujima, Ryosuke Yamaga, Haruka Minami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3240-20.2021"}], "href": "https://doi.org/10.1523/JNEUROSCI.3240-20.2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33846232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33846232"}]}]}]}
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Synonyms | C1ORF126 |
NCBI Gene ID | 200197 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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TMEM51-AS1 has 2,132 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 28 datasets.
Click the + buttons to view associations for TMEM51-AS1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TMEM51-AS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TMEM51-AS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TMEM51-AS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TMEM51-AS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM51-AS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of TMEM51-AS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TMEM51-AS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TMEM51-AS1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM51-AS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of TMEM51-AS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TMEM51-AS1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TMEM51-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TMEM51-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TMEM51-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TMEM51-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TMEM51-AS1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TMEM51-AS1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GWASdb SNP-Disease Associations | diseases associated with TMEM51-AS1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with TMEM51-AS1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with TMEM51-AS1 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TMEM51-AS1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TMEM51-AS1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of TMEM51-AS1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TMEM51-AS1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TMEM51-AS1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TMEM51-AS1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TMEM51-AS1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TMEM51-AS1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |