TMEM56-RWDD3 Gene

Name	TMEM56-RWDD3 readthrough
Description	This locus represents naturally occurring read-through transcription between the neighboring TMEM56 (transmembrane protein 56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010]
NCBI Gene ID	100527978
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TMEM56-RWDD3 has 1,293 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 22 datasets.

Click the + buttons to view associations for TMEM56-RWDD3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TMEM56-RWDD3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM56-RWDD3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TMEM56-RWDD3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM56-RWDD3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TMEM56-RWDD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TMEM56-RWDD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TMEM56-RWDD3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM56-RWDD3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TMEM56-RWDD3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GO Cellular Component Annotations 2015	cellular components containing TMEM56-RWDD3 protein from the curated GO Cellular Component Annotations 2015 dataset.
	GWASdb SNP-Disease Associations	diseases associated with TMEM56-RWDD3 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with TMEM56-RWDD3 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	HPA Cell Line Gene Expression Profiles	cell lines with high or low expression of TMEM56-RWDD3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of TMEM56-RWDD3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TMEM56-RWDD3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of TMEM56-RWDD3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM56-RWDD3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of TMEM56-RWDD3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	cell lines with TMEM56-RWDD3 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of TMEM56-RWDD3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of TMEM56-RWDD3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TMEM56-RWDD3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of TMEM56-RWDD3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.