{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTMEM92‑AS1 is a long noncoding RNA that is significantly overexpressed in gastric cancer tissues compared to adjacent normal tissues, and its high expression correlates with reduced overall and disease‑free survival. Functional assays demonstrate that TMEM92‑AS1 promotes cancer cell proliferation, migration, and tumorigenic ability both in vitro and in vivo, suggesting a key oncogenic role in the progression of gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies reveal that TMEM92‑AS1 exerts its effects by binding to the transcription factor Y‑box binding protein 1 (YBX1) to regulate the expression of the chemokine C‑C motif chemokine ligand 5 (CCL5), which contributes to the oncogenic process. In addition, this lncRNA appears to influence the levels of peripheral blood leukocytes, particularly neutrophils, potentially through modulation of granulocyte colony‑stimulating factor expression in gastric cancer tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shubin Song, Xuezhi He, Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel long noncoding RNA, TMEM92-AS1, promotes gastric cancer progression by binding to YBX1 to mediate CCL5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12863"}], "href": "https://doi.org/10.1002/1878-0261.12863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33247987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33247987"}]}]}]}