TNIK Gene

Name	TRAF2 and NCK interacting kinase
Description	Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTNIK (TRAF2‐ and NCK‐interacting kinase) is a serine/threonine kinase that has emerged as a multifunctional regulator of cellular signaling. Early studies identified TNIK as a specific effector of the small GTPase Rap2, mediating disruptions in F‐actin organization and cell spreading (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its critical role in neuronal cells has since been demonstrated; TNIK regulates dendrite development and synaptic transmission, and loss‐of-function mutations have been linked to intellectual disability, while alternative splicing modulated by neuron‐specific factors further tunes its activity and impacts neuritogenesis (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in the nervous system, TNIK is a pivotal mediator of the canonical Wnt/β‐catenin pathway. It promotes transcriptional activation of key target genes—for example, cyclin D1 and c‐MYC—that drive cell proliferation and survival. Studies have shown that TNIK is essential for Wnt‐mediated intestinal stem cell maintenance and tumor initiation; its inhibition reduces tumorigenesis in colorectal, hepatocellular, pancreatic, and ovarian cancers (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "15"}]}, {"type": "t", "text": " Furthermore, in multiple myeloma TNIK supports cancer cell proliferation, reinforcing its promise as a potential therapeutic target (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTNIK also contributes significantly to immune and stress‐related signaling. In B‐cells, it helps to propagate NF‐κB and c‐Jun N‐terminal kinase (JNK) activation in response to oncogenic signals, such as those delivered by Epstein–Barr virus oncoproteins (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Its levels are dynamically modulated by protein–protein interactions—for example, through ubiquitin‐dependent mechanisms involving TRAF2—which in turn influence signaling outcomes. Moreover, modulation of TNIK has been linked to cellular responses to antipsychotic agents and may affect drug resistance, as evidenced by studies in glioma cells and genetic associations with risperidone response (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, large‐scale genetic and epigenetic studies further underscore the broad clinical impact of TNIK. Genome‐wide association studies and differential methylation analyses have implicated TNIK in complex disorders such as adolescent idiopathic scoliosis and schizophrenia, thereby expanding its relevance beyond classical oncogenic and neuronal pathways (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Collectively, these findings establish TNIK as an integrative signaling hub that regulates cytoskeletal dynamics, transcriptional programs via the Wnt/β‐catenin pathway, and stress‐associated responses in both normal physiology and disease pathogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kiyohito Taira, Masato Umikawa, Kimiko Takei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M406370200"}], "href": "https://doi.org/10.1074/jbc.M406370200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15342639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15342639"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Steven G Potkin, Jessica A Turner, Guia Guffanti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Bull (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/schbul/sbn155"}], "href": "https://doi.org/10.1093/schbul/sbn155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19023125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19023125"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qi Wang, Stephen P Amato, David M Rubitski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.115.229880"}], "href": "https://doi.org/10.1124/jpet.115.229880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26645429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26645429"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shams Anazi, Hanan E Shamseldin, Dhekra AlNaqeb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A null mutation in TNIK defines a novel locus for intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-016-1671-9"}], "href": "https://doi.org/10.1007/s00439-016-1671-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27106596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27106596"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Valentina Gumina, Claudia Colombrita, Claudia Fallini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2019.194413"}], "href": "https://doi.org/10.1016/j.bbagrm.2019.194413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31382054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31382054"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fa-Yi Nie, Miao-Ran Zhang, Shan-Shan Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylome-wide association study of first-episode schizophrenia reveals a hypermethylated CpG site in the promoter region of the TNIK susceptibility gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2020.110081"}], "href": "https://doi.org/10.1016/j.pnpbp.2020.110081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32853717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32853717"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jinghua Gui, Baotian Yang, Jinyun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enormous influence of TNIK knockdown on intracellular signals and cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-011-0023-2"}], "href": "https://doi.org/10.1007/s13577-011-0023-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21710359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21710359"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Robyn Meech, Anne Rogers, Lizhe Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.343608"}], "href": "https://doi.org/10.1074/jbc.M112.343608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22621930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22621930"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jing Jin, Hae Yoen Jung, Yuli Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2013.10.007"}], "href": "https://doi.org/10.1016/j.prp.2013.10.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25160513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25160513"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yong Zhang, Hongwei Jiang, Mingfang Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIK serves as a novel biomarker associated with poor prognosis in patients with pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3881-5"}], "href": "https://doi.org/10.1007/s13277-015-3881-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26269113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26269113"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hidenori Takahashi, Toshiaki Ishikawa, Megumi Ishiguro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-015-1783-y"}], "href": "https://doi.org/10.1186/s12885-015-1783-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26499327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26499327"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mari Masuda, Yuko Uno, Naomi Ohbayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIK inhibition abrogates colorectal cancer stemness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12586"}], "href": "https://doi.org/10.1038/ncomms12586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27562646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27562646"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yura Lee, Jung-Il Jung, Kyeong-Yong Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.17056"}], "href": "https://doi.org/10.18632/oncotarget.17056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28467797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28467797"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chihiro Takahashi, Shingo Kondo, Kensuke Sadaoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.136"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32828291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32828291"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaoling Wu, Youwen Zhong, Hua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-5590-3p inhibits the proliferation and invasion of ovarian cancer cells through mediating the Wnt/β-catenin signaling pathway by targeting TNIK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-636"}], "href": "https://doi.org/10.14670/HH-18-636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37318197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37318197"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hae Jung Chon, Yura Lee, Kyoung Jun Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-016-2214-3"}], "href": "https://doi.org/10.1007/s00726-016-2214-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26995282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26995282"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anna Shkoda, Jennifer A Town, Janine Griese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1001376"}], "href": "https://doi.org/10.1371/journal.pbio.1001376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22904686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22904686"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ruixue Yuan, Yaojing Li, Yingmei Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIK influence the effects of antipsychotics on Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-021-05943-3"}], "href": "https://doi.org/10.1007/s00213-021-05943-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34350475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34350475"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qingqing Xu, Yaojing Li, Mo Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx045"}], "href": "https://doi.org/10.1093/hmg/ddx045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28334814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28334814"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Y Qiu "}, {"type": "b", "children": [{"type": "t", "text": "[The current review and prospects of the genetic study and clinical treatment of adolescent idiopathic scoliosis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Wai Ke Za Zhi (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.0529-5815.2018.08.005"}], "href": "https://doi.org/10.3760/cma.j.issn.0529-5815.2018.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30107698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30107698"}]}]}]}
Synonyms	MRT54
Proteins	TNIK_HUMAN
NCBI Gene ID	23043
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNIK has 9,326 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 136 datasets.

Click the + buttons to view associations for TNIK from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNIK Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNIK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNIK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNIK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNIK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNIK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNIK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TNIK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNIK gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNIK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TNIK gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNIK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNIK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TNIK gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TNIK protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNIK gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNIK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNIK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TNIK gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TNIK protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNIK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNIK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TNIK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNIK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNIK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNIK gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNIK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNIK gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNIK gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TNIK gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNIK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TNIK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TNIK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TNIK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TNIK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TNIK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TNIK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TNIK gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNIK gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TNIK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TNIK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.