TNKS1BP1 Gene

Name	tankyrase 1 binding protein 1, 182kDa
Description	Enables ankyrin repeat binding activity and enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including adherens junction; heterochromatin; and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTNKS1BP1, originally identified as a tankyrase‐1 binding protein, has emerged as a multifunctional factor in the maintenance of genome stability. Initially characterized as a poly(ADP‐ribosyl)ation acceptor, TNKS1BP1 plays a critical role in the repair of DNA double‐strand breaks. It interacts with key repair proteins such as DNA‐PKcs and PARP‐1, promoting DNA‐PKcs autophosphorylation and thereby facilitating efficient DNA damage repair responses. In certain cancer contexts, its overexpression modulates cell cycle progression—leading to increased S phase accumulation and altered homologous recombination efficiency through effects on RAD51 foci formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruption in TNKS1BP1 function also impacts cytoskeletal dynamics and cell motility. By colocalizing with actin filaments and binding to actin‐capping proteins such as CapZA2, TNKS1BP1 acts as a negative regulator of cell invasion. Its modulation of actin filament dynamics and focal adhesion turnover suggests that the protein contributes to limiting invasive cell behavior, an effect that ties into its broader influence on cancer cell aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "Moreover, context‐dependent roles of TNKS1BP1 (also referred to as TAB182) have been documented in various tumors. In esophageal cancer models, for example, TNKS1BP1 has been implicated in promoting tumorigenesis through activation of the β‐catenin signaling pathway, while in lung and breast cancers, its dysregulation correlates with altered sensitivity to DNA damaging agents and changes in cancer stem‐like cell properties. In lung adenocarcinoma, its upregulation is associated with resistance to chemoradiotherapy, whereas in triple‐negative breast cancer, reduced TNKS1BP1 levels contribute to enhanced cell proliferation, invasion, and therapy resistance by affecting key downstream pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lian-Hong Zou, Zeng-Fu Shang, Wei Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3137"}], "href": "https://doi.org/10.18632/oncotarget.3137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25749521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25749521"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Tan, Hua Guan, Lian-Hong Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.995"}], "href": "https://doi.org/10.1002/cam4.995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28058814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28058814"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomokazu Ohishi, Haruka Yoshida, Masamichi Katori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-1846"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-1846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28202517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28202517"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hongyao Jia, Di Wu, Zhiru Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioorg Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bioorg.2020.104301"}], "href": "https://doi.org/10.1016/j.bioorg.2020.104301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33011533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33011533"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aidi Gao, Zhenzi Su, Zengfu Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05334-2"}], "href": "https://doi.org/10.1038/s41419-022-05334-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36289198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36289198"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shaozheng Wang, Hejiang Guo, Jin Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-022-08176-5"}], "href": "https://doi.org/10.1007/s11033-022-08176-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36689051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36689051"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huan He, Shaozheng Wang, Wen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of TAB182 promotes cancer stem-like cell properties and therapeutic resistance in triple-negative breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-023-11552-4"}], "href": "https://doi.org/10.1186/s12885-023-11552-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37953246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37953246"}]}]}]}
Synonyms	TAB182
Proteins	TB182_HUMAN
NCBI Gene ID	85456
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNKS1BP1 has 5,948 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for TNKS1BP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNKS1BP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNKS1BP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNKS1BP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNKS1BP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNKS1BP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNKS1BP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNKS1BP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNKS1BP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNKS1BP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNKS1BP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TNKS1BP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TNKS1BP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNKS1BP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNKS1BP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNKS1BP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TNKS1BP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNKS1BP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TNKS1BP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TNKS1BP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNKS1BP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNKS1BP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNKS1BP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNKS1BP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNKS1BP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNKS1BP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNKS1BP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TNKS1BP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TNKS1BP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TNKS1BP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TNKS1BP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TNKS1BP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNKS1BP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TNKS1BP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TNKS1BP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TNKS1BP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TNKS1BP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of TNKS1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of TNKS1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of TNKS1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNKS1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of TNKS1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.