{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNA TOB1‐AS1 is emerging as a regulatory molecule implicated in various disease processes. In gastric cancer, TOB1‐AS1 has been detected as a participant in tumor progression; however, its specific molecular role in the development and advancement of gastric cancer remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn the context of autoimmune disorders such as multiple sclerosis, TOB1‐AS1 appears to be involved in the maintenance of immune tolerance. Studies have shown that its expression levels negatively correlate with disease severity (EDSS) and are associated with a dysregulated co‐expression network alongside coding genes such as TOB1, SKP2, and TSG. These findings suggest that disruptions in this regulatory pathway may contribute to MS pathogenesis and influence response to therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nSimilarly, in esophageal squamous cell carcinoma the antisense transcript TOB1‐AS1, found in a head‐to‐head orientation with TOB1, is consistently down‐regulated, a pattern also observed in several cancer types. Although the definitive biological roles of TOB1‐AS1 and its partner TOB1 in this malignancy are not yet clarified, their altered expression profiles indicate a potential involvement in cancer progression and warrant further investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "K Jiang, X-H Zhi, Y-Y Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TOB1-AS1 modulates cell proliferation, apoptosis, migration and invasion through miR-23a/NEU1 axis via Wnt/b-catenin pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201911_19554"}], "href": "https://doi.org/10.26355/eurrev_201911_19554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31799657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31799657"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Reyhaneh Dehghanzad, Majid Pahlevan Kakhki, Asieh Alikhah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-019-08567-1"}], "href": "https://doi.org/10.1007/s12017-019-08567-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31482275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31482275"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhiming Dong, Guoqiang Zhang, Juntao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-022-07664-9"}], "href": "https://doi.org/10.1007/s10620-022-07664-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36002674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36002674"}]}]}]}