| Name | transmembrane O-methyltransferase |
| Description | This gene encodes a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. Readthrough transcription is observed across this gene and the adjacent leucine-rich repeat containing 51 gene. A third locus (GeneID:220074) is defined to represent the readthrough transcripts. [provided by RefSeq, Feb 2021] |
| NCBI Gene ID | 120356740 |
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| Predicted Functions |
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| Expression in Tissues and Cell Lines |
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TOMT has 323 functional associations with biological entities spanning 4 categories (disease, phenotype or trait, functional term, phrase or reference, chemical, gene, protein or microRNA) extracted from 12 datasets.
Click the + buttons to view associations for TOMT from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with TOMT gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TOMT gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TOMT gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TOMT gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TOMT gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TOMT gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| KEGG Pathways 2026 | pathways involving TOMT protein from the KEGG Pathways 2026 dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TOMT gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving TOMT protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TOMT gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TOMT gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TOMT gene from the RummaGEO Gene Perturbation Signatures dataset. | |
