{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study evaluated genome‐wide bipolar disorder susceptibility variants for their potential pleiotropic effects on co‐occurring medical conditions by analyzing data from electronic health records. Notably, the abstract (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "focused on risk variants in genes such as CACNA1C and SVEP1 that appear to influence cardiovascular traits like cardiac dysrhythmias and essential hypertension. However, there was no specific mention or discussion of TOP6BL’s function in the reported results.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile the investigation provided compelling evidence connecting certain genetic variants with both psychiatric and cardiovascular phenotypes, TOP6BL was not characterized or analyzed in the context of the study. In the absence of any conveyed functional data or mechanistic insights, it remains unclear what role TOP6BL might play in these or other related biological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe approach underscored the utility of large-scale, EHR-based genomic studies to reveal complex genetic interactions underlying multimorbid conditions. Future inquiries would be needed to elucidate the biological function of TOP6BL and determine whether it exerts any pleiotropic effects similar to those observed for other candidate genes in disorders such as bipolar disorder and cardiovascular disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M L Prieto, E Ryu, G D Jenkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2016.138"}], "href": "https://doi.org/10.1038/tp.2016.138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27529678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27529678"}]}]}]}