TP53I3 Gene

Name	tumor protein p53 inducible protein 3
Description	The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTP53I3 (also known as PIG3) is a p53‐inducible gene originally identified as a downstream target of p53 with a multifaceted role in the cellular response to DNA damage. Upon genotoxic stress such as UV irradiation or radiomimetic drug treatment, TP53I3 is rapidly recruited to nuclear foci where it colocalizes with γ‐H2AX and 53BP1, thereby contributing to the activation and maintenance of intra‐S and G2/M cell cycle checkpoints. In addition, TP53I3 exhibits NADPH‐dependent quinone oxidoreductase activity that generates reactive oxygen species (ROS) to trigger apoptotic pathways. Its function is further refined by alternative pre‐mRNA splicing events—yielding, for example, the unstable PIG3AS isoform under UV stress—and by modulation from certain p53 mutants that alter its transcriptional activation. Variations in a pentanucleotide repeat within its promoter have also been implicated in modifying p53 binding and have been examined in relation to cancer susceptibility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n\nMedically, TP53I3’s ability to generate ROS is central to its pro‐apoptotic activity. Studies in prostate cancer models have demonstrated that TP53I3 interacts directly with glutathione peroxidase 3 (GPx3) to form a signaling axis that enhances ROS production and caspase‐mediated cell death—including responses to UV irradiation. In addition, TP53I3 has been implicated in non‐apoptotic cell death pathways such as necroptosis where its expression influences ROS levels. Interactions with regulatory proteins (for example, prohibitin) further modulate its transcriptional activation and underscore its complex role in stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "In the cancer setting, TP53I3 exhibits context‐dependent roles. Loss or reduced expression of TP53I3 has been observed in gastric cancer, where its restoration—via p53‐mediated apoptosis—suppresses tumor cell proliferation. Conversely, aberrant overexpression has been linked to oncogenic processes; for example, in papillary thyroid carcinoma and non–small cell lung cancer (NSCLC), altered TP53I3 levels correlate with enhanced activation of pathways such as PI3K/AKT/PTEN and FAK/Src/paxillin that promote cell proliferation, migration, and metastasis. In renal cell carcinoma, knockdown of TP53I3 increases HIF-1α protein production through the mTOR pathway, thereby stimulating VEGF secretion and cell migration. Moreover, in glioblastoma, higher TP53I3 expression is associated with reduced tumor aggressiveness and improved patient survival, underscoring its potential utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chris D Nicholls, Michael A Shields, Patrick W K Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401049200"}], "href": "https://doi.org/10.1074/jbc.M401049200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15067011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15067011"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sárka Pospísilová, Christine Siligan, Jozet Ban, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15192123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15192123"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "V G Gorgoulis, T Liloglou, F Sigala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrfmmm.2004.07.008"}], "href": "https://doi.org/10.1016/j.mrfmmm.2004.07.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15491642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15491642"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chris D Nicholls, Tara L Beattie "}, {"type": "b", "children": [{"type": "t", "text": "Multiple factors influence the normal and UV-inducible alternative splicing of PIG3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2008.08.009"}], "href": "https://doi.org/10.1016/j.bbagrm.2008.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18801469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18801469"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sergio Porté, Eva Valencia, Evgenia A Yakovtseva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.001800"}], "href": "https://doi.org/10.1074/jbc.M109.001800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19349281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19349281"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J-H Lee, Y Kang, V Khare, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.438"}], "href": "https://doi.org/10.1038/onc.2009.438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20023697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20023697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaoxiang Guan, Zhensheng Liu, Luo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgs388"}], "href": "https://doi.org/10.1093/carcin/bgs388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23241165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23241165"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hui Wang, Katherine Luo, Lang-Zhu Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.322636"}], "href": "https://doi.org/10.1074/jbc.M111.322636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22461624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22461624"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaoxiang Guan, Zhensheng Liu, Luo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.12.124"}], "href": "https://doi.org/10.1016/j.bbrc.2013.12.124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24388982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24388982"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ying Jiang, Shigang Shan, Linfeng Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3531-y"}], "href": "https://doi.org/10.1007/s13277-015-3531-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26472723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26472723"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jinye Xu, Junbo Cai, Xiaoyan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4096"}], "href": "https://doi.org/10.3892/or.2015.4096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26133772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26133772"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Guang Chen, Jin-Ye Xu, Jie Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8401"}], "href": "https://doi.org/10.18632/oncotarget.8401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27029070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27029070"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ming Li, Shanhu Li, Biao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-017-0508-2"}], "href": "https://doi.org/10.1186/s13046-017-0508-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28259183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28259183"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jishu Quan, Yong Li, Meihua Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of p53-inducible gene 3 is significant for glioblastoma progression and predicts poor patient prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317694572"}], "href": "https://doi.org/10.1177/1010428317694572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28351326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28351326"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Meng-Meng Gu, Dexuan Gao, Ping-An Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-inducible gene 3 promotes cell migration and invasion by activating the FAK/Src pathway in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13818"}], "href": "https://doi.org/10.1111/cas.13818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30281878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30281878"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Y Chu, D Li, H Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30334411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30334411"}]}]}]}
Synonyms	PIG3
Proteins	QORX_HUMAN
NCBI Gene ID	9540
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TP53I3 has 7,576 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 113 datasets.

Click the + buttons to view associations for TP53I3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TP53I3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TP53I3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TP53I3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TP53I3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TP53I3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TP53I3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TP53I3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TP53I3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TP53I3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TP53I3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TP53I3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TP53I3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TP53I3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TP53I3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TP53I3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TP53I3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TP53I3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TP53I3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TP53I3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TP53I3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TP53I3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TP53I3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TP53I3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TP53I3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TP53I3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TP53I3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TP53I3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TP53I3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TP53I3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TP53I3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TP53I3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TP53I3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TP53I3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TP53I3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TP53I3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TP53I3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TP53I3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with TP53I3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TP53I3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TP53I3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TP53I3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.