{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTP53INP1 is a stress‐inducible nuclear protein whose expression is upregulated by p53 and p73 and is critical for mediating cell cycle arrest, apoptosis, and autophagy. Early studies demonstrated that TP53INP1, expressed as two isoforms, is induced under conditions of cellular stress, leading to its accumulation in nuclear domains with p53 and HIPK2 to modulate transcription of key cell cycle and pro‐apoptotic genes (e.g. p21, Mdm2, Bax) and to trigger programmed cell death pathways. In addition, TP53INP1 has been shown to interact with autophagy‐related proteins (such as LC3 via an LC3–interacting region) to initiate autophagy‐dependent cell death, and its post‐translational modification by SUMOylation promotes antioxidant responses under oxidative stress. These functional studies underscore its role as a tumor suppressor and mediator of stress responses, as further evidenced by its induction in stress‐induced models and its ability to enhance radiosensitivity by regulating autophagy and the clearance of damaged mitochondria."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA recurrent theme in multiple tumor models is the down‐regulation of TP53INP1 by distinct microRNAs, which in turn compromises its tumor‐suppressive functions. In various cancers—including HTLV‐1–transformed T cells, cervical, breast, gastric, liver, esophageal, nasopharyngeal, and lung adenocarcinomas—a number of oncomiRs (such as miR‐93, miR‐130b, miR‐155, miR‐17‑5p, miR‐182, miR‐504, miR‐569, miR‐124‑3p, miR‐15a‑5p, among others) directly target the 3′‐UTR of TP53INP1 transcripts. This microRNA‐mediated suppression of TP53INP1 has been associated with enhanced cell proliferation, reduced apoptosis, epithelial–mesenchymal transition, invasion, chemoresistance, and metastasis. Furthermore, competitive endogenous RNA networks that sequester specific miRNAs have been shown to restore TP53INP1 levels and limit tumor progression, highlighting its pivotal role as an inhibitor of malignant transformation and metastatic spread."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer, altered TP53INP1 expression has clinical relevance in other contexts. In several non‐tumor models, diminished or aberrant TP53INP1 levels have been linked to disease progression and tissue dysfunction. For instance, studies in thyroid and prostate neoplasms have correlated TP53INP1 expression with clinical outcomes, while in non‐malignant systems TP53INP1 participates in the regulation of cell cycle progression in granulosa cells during follicular development and modulates cardiac fibroblast proliferation and collagen formation following myocardial infarction. In age‐related cataract, TP53INP1 expression is upregulated via MEG3‐mediated pathways, promoting pro‐apoptotic responses in lens epithelial cells. These findings collectively underscore the importance of TP53INP1 not only as a guardian against tumorigenesis but also as a critical regulator of cellular homeostasis in diverse physiological and pathological settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Richard Tomasini, Amina Azizi Samir, Marie-Josèphe Pebusque, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P53-dependent expression of the stress-induced protein (SIP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1078/0171-9335-00248"}], "href": "https://doi.org/10.1078/0171-9335-00248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12067065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12067065"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Richard Tomasini, Amina Azizi Samir, Alice Carrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301979200"}], "href": "https://doi.org/10.1074/jbc.M301979200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12851404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12851404"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Richard Tomasini, Mylène Seux, Jonathan Nowak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208951"}], "href": "https://doi.org/10.1038/sj.onc.1208951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16044147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16044147"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Pei-Hong Jiang, Yoshiharu Motoo, Stéphane Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v12.i5.691"}], "href": "https://doi.org/10.3748/wjg.v12.i5.691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16521180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16521180"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Seillier, S Peuget, O Gayet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2012.30"}], "href": "https://doi.org/10.1038/cdd.2012.30"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22421968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22421968"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ana Sancho, Jordi Duran, Antonio García-España, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034034"}], "href": "https://doi.org/10.1371/journal.pone.0034034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22470510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22470510"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "S Peuget, T Bonacci, P Soubeyran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.28"}], "href": "https://doi.org/10.1038/cdd.2014.28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24608790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24608790"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wenhao Weng, Qinyuan Yang, Miaolong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Myc inhibits TP53INP1 expression via promoter methylation in esophageal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.01.028"}], "href": "https://doi.org/10.1016/j.bbrc.2011.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21219856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21219856"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nikolett Sándor, Boglárka Schilling-Tóth, Enikő Kis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms161025450"}], "href": "https://doi.org/10.3390/ijms161025450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26512655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26512655"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Man Lung Yeung, Jun-ichirou Yasunaga, Yamina Bennasser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0769"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18974142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18974142"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qian Wei, Yi-Xuan Li, Min Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1051"}], "href": "https://doi.org/10.1002/iub.1051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22730212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22730212"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Chunmei Zhang, Jing Zhao, Huayu Deng "}, {"type": "b", "children": [{"type": "t", "text": "17β-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-013-1642-6"}], "href": "https://doi.org/10.1007/s11010-013-1642-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23568502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23568502"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chun-Mei Zhang, Jing Zhao, Hua-Yu Deng "}, {"type": "b", "children": [{"type": "t", "text": "MiR-155 promotes proliferation of human breast cancer MCF-7 cells through targeting tumor protein 53-induced nuclear protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biomed Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1423-0127-20-79"}], "href": "https://doi.org/10.1186/1423-0127-20-79"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24152184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24152184"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jun Qin, Meng Luo, Haixin Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.12.043"}], "href": "https://doi.org/10.1016/j.gene.2013.12.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24447717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24447717"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jie Zhang, Chen Cheng, Xiang Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-155 acts as an oncogene by targeting the tumor protein 53-induced nuclear protein 1 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24551280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24551280"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Pradeep Chaluvally-Raghavan, Fan Zhang, Sunila Pradeep, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2014.10.010"}], "href": "https://doi.org/10.1016/j.ccell.2014.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25490449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25490449"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fengchao Liu, Xin Kong, Lin Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.01.009"}], "href": "https://doi.org/10.1016/j.febslet.2015.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25601564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25601564"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Fengchao Liu, Xin Kong, Lin Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.01.030"}], "href": "https://doi.org/10.1016/j.canlet.2015.01.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25633840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25633840"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Guohui Nie, Hongfang Duan, Xiaoqing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2015.4181"}], "href": "https://doi.org/10.3892/mmr.2015.4181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26252115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26252115"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yulia Margolin-Miller, Natalia Yanichkin, Keren Shichrur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.22467"}], "href": "https://doi.org/10.1002/gcc.22467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28437838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28437838"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Qingchun Cai, Sixiang Zeng, Xing Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-504 promotes tumour growth and metastasis in human osteosarcoma by targeting TP53INP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5983"}], "href": "https://doi.org/10.3892/or.2017.5983"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29048685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29048685"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lufeng Zheng, Xiaoman Li, Jinjiang Chou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "StarD13 3'-untranslated region functions as a ceRNA for TP53INP1 in prohibiting migration and invasion of breast cancer cells by regulating miR-125b activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2017.11.002"}], "href": "https://doi.org/10.1016/j.ejcb.2017.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29146309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29146309"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yi Wang, Huizhi Sun, Danfang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1 inhibits hypoxia-induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13625"}], "href": "https://doi.org/10.1111/jcmm.13625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29655255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29655255"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "X-Q Zhao, H Tang, J Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-15a-5p down-regulation inhibits cervical cancer by targeting TP53INP1 in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201910_19129"}], "href": "https://doi.org/10.26355/eurrev_201910_19129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31646552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31646552"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shuai-Shuai Shi, Hui-Peng Zhang, Chang-Qing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.152986"}], "href": "https://doi.org/10.1016/j.prp.2020.152986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32527448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32527448"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Lei Han, Zeyong Huang, Yan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04324-0"}], "href": "https://doi.org/10.1038/s41419-021-04324-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34718338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34718338"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yasuhiro Ito, Yoshiharu Motoo, Hiroshi Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00313020601024094"}], "href": "https://doi.org/10.1080/00313020601024094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17393983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17393983"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Sophie Giusiano, Stéphane Garcia, Claudia Andrieu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.21412"}], "href": "https://doi.org/10.1002/pros.21412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21538421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21538421"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sophie Giusiano, Virginie Baylot, Claudia Andrieu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP1 as new therapeutic target in castration-resistant prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.22477"}], "href": "https://doi.org/10.1002/pros.22477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22213058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22213058"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Zhiqian Wang, Mingming Fu, Yongjun Li "}, {"type": "b", "children": [{"type": "t", "text": "miR-142-5p and miR-212-5p cooperatively inhibit the proliferation and collagen formation of cardiac fibroblasts by regulating c-Myc/TP53INP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Can J Physiol Pharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/cjpp-2019-0495"}], "href": "https://doi.org/10.1139/cjpp-2019-0495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32268073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32268073"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yuanyuan Tu, Laiqing Xie, Lili Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Eye Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exer.2020.108185"}], "href": "https://doi.org/10.1016/j.exer.2020.108185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32841649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32841649"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Chengyu Li, Zhaojun Liu, Gang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.199453"}], "href": "https://doi.org/10.1242/dev.199453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34152408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34152408"}]}]}]}