{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTCTP (also known as TPT1) is a multifunctional protein that plays a central role in cell division. It binds and stabilizes microtubules, interacts with key mitotic kinases such as Plk, and modulates spindle dynamics during mitosis. In addition, TCTP associates with translation elongation factors—acting as a guanine nucleotide dissociation inhibitor—to couple translational efficiency with cell cycle progression and growth regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTCTP exerts potent antiapoptotic effects by interfering with cell death pathways. It promotes the degradation of p53 and prevents the activation of pro-apoptotic factors such as Bax, thereby contributing to tumor cell survival and resistance to stress-induced apoptosis. RNA interference–based studies in diverse cancer models have validated its importance in maintaining a malignant phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in apoptosis, TCTP participates in the regulation of cell growth and metabolism through the mTOR signaling axis. Controversy has existed regarding its precise impact on mTOR complex 1; however, evidence indicates that TCTP can function as a guanine nucleotide exchange factor for Rheb, thereby promoting mTORC1 activation. It is also subject to PI3K/Akt/mTOR-dependent translational control and modulates autophagy via interactions that affect key regulators such as BECN1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTCTP also functions in an extracellular capacity as the histamine-releasing factor (HRF). Secreted via nonclassical pathways such as exosome release mediated by TSAP6, extracellular TCTP modulates immune responses by stimulating cytokine secretion from bronchial epithelial cells and priming basophils for degranulation. These features contribute to inflammatory and allergic responses, including aspects of food allergy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUnder various cellular stresses, TCTP demonstrates molecular chaperone–like activity by binding denatured proteins to protect them from thermal damage and other stressors. It additionally exhibits calcium-binding capabilities, a property that is important for maintaining calcium homeostasis in specific contexts such as the placenta. Comprehensive reviews have highlighted these cytoprotective roles as integral to its ability to sustain cell viability under adverse conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, aberrant TCTP expression is associated with aggressive tumor phenotypes and poor prognosis in a range of disorders. Overexpression is observed in glioma, prostate, oral, and breast cancers as well as in NF1-associated tumors and pulmonary arterial hypertension. 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"}, {"type": "b", "children": [{"type": "t", "text": "Role of the translationally controlled tumor protein in DNA damage sensing and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1106300109"}], "href": "https://doi.org/10.1073/pnas.1106300109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22451927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22451927"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tim Hon Man Chan, Leilei Chen, Ming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.24709"}], "href": "https://doi.org/10.1002/hep.24709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21953552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21953552"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marcel Tuynder, Laurent Susini, Sylvie Prieur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.222470799"}], "href": "https://doi.org/10.1073/pnas.222470799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12399545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12399545"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Robert Amson, Salvatore Pece, Alexandra Lespagnol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal repression between P53 and TCTP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2546"}], "href": "https://doi.org/10.1038/nm.2546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157679"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "L Susini, S Besse, D Duflaut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCTP protects from apoptotic cell death by antagonizing bax function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2008.18"}], "href": "https://doi.org/10.1038/cdd.2008.18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18274553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18274553"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Seung Bae Rho, Jeong Heon Lee, Mi Sun Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.11.014"}], "href": "https://doi.org/10.1016/j.febslet.2010.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21081126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21081126"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Potchanapond Graidist, Amornrat Phongdara, Ken Fujise "}, {"type": "b", "children": [{"type": "t", "text": "Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401454200"}], "href": "https://doi.org/10.1074/jbc.M401454200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15262975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15262975"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yanjie Chen, Takayuki Fujita, Di Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.217836"}], "href": "https://doi.org/10.1074/jbc.M110.217836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21795694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21795694"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Munirathinam Gnanasekar, Sivasakthivel Thirugnanam, Guoxing Zheng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803348200"}], "href": "https://doi.org/10.1074/jbc.M803348200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18676370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18676370"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xianchi Dong, Bei Yang, Yingjie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.012823"}], "href": "https://doi.org/10.1074/jbc.M109.012823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570981"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ulrich-Axel Bommer, Valentina Iadevaia, Jiezhong Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2017.1287650"}], "href": "https://doi.org/10.1080/15548627.2017.1287650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28409693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28409693"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jian Zhang, Shuohui Gao, Yandong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.46822"}], "href": "https://doi.org/10.7150/ijbs.46822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32792860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32792860"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Qiu Du, Bin Hu, Yajuan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2018-01851"}], "href": "https://doi.org/10.1210/jc.2018-01851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30721952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30721952"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ulrich-Axel Bommer, Kara L Vine, Prianka Puri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-017-0164-3"}], "href": "https://doi.org/10.1186/s12964-017-0164-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28143584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28143584"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Nathalie Amzallag, Brent J Passer, David Allanic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404850200"}], "href": "https://doi.org/10.1074/jbc.M404850200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15319436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15319436"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "I Sirois, M-A Raymond, N Brassard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2010.126"}], "href": "https://doi.org/10.1038/cdd.2010.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20966960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20966960"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kazuo Yoneda, Kazuhito Rokutan, Yoichi Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00118.2003"}], "href": "https://doi.org/10.1152/ajplung.00118.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12948934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12948934"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Becky M Vonakis, Donald W Macglashan, Natalia Vilariño, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced priming and activation of human basophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-104364"}], "href": "https://doi.org/10.1182/blood-2007-07-104364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18042794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18042794"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Tomoaki Ando, Jun-Ichi Kashiwakura, Naoka Itoh-Nagato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histamine-releasing factor enhances food allergy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI96525"}], "href": "https://doi.org/10.1172/JCI96525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29130935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29130935"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Munirathinam Gnanasekar, Gajalakshmi Dakshinamoorthy, Kalyanasundaram Ramaswamy "}, {"type": "b", "children": [{"type": "t", "text": "Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.06.028"}], "href": "https://doi.org/10.1016/j.bbrc.2009.06.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19523440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19523440"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yingang Feng, Dongsheng Liu, Hongwei Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2007.08.021"}], "href": "https://doi.org/10.1016/j.abb.2007.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17897616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17897616"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Felice Arcuri, Stefania Papa, Antonella Meini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.105.042077"}], "href": "https://doi.org/10.1095/biolreprod.105.042077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15958728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15958728"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ulrich-Axel Bommer "}, {"type": "b", "children": [{"type": "t", "text": "The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Results Probl Cell Differ (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/978-3-319-67591-6_4"}], "href": "https://doi.org/10.1007/978-3-319-67591-6_4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29149404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29149404"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xuefeng Gu, Lifen Yao, Guoda Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/not194"}], "href": "https://doi.org/10.1093/neuonc/not194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24311645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24311645"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Xia Miao, Yong-Bin Chen, Sheng-Long Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCTP overexpression is associated with the development and progression of glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-013-0906-9"}], "href": "https://doi.org/10.1007/s13277-013-0906-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23749504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23749504"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Sara Karaki, Sebastien Benizri, Raquel Mejías, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Control Release (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jconrel.2017.04.042"}], "href": "https://doi.org/10.1016/j.jconrel.2017.04.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28472637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28472637"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Wan-Yu Lo, Huang-Joe Wang, Chih-Wei Chiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2012.07.039"}], "href": "https://doi.org/10.1016/j.jprot.2012.07.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22902387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22902387"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Maria Lucibello, Sara Adanti, Ester Antelmi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2971"}], "href": "https://doi.org/10.18632/oncotarget.2971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25779659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25779659"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Daiki Kobayashi, Mio Hirayama, Yoshihiro Komohara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.568253"}], "href": "https://doi.org/10.1074/jbc.M114.568253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25092287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25092287"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2017-0129OC"}], "href": "https://doi.org/10.1165/rcmb.2017-0129OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29676587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29676587"}]}]}]}