{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRAF3IP2‐AS1 is a natural antisense long non‐coding RNA whose functional roles appear to be context‐dependent. In NONO‐TFE3 translocation renal cell carcinoma, a subtype of Xp11.2 tRCC, its involvement has been noted; however, its specific mechanisms in this setting remain poorly understood."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nRecent work in the context of autoimmune diseases has revealed an intriguing role for TRAF3IP2‐AS1 in modulating the IL-17A signaling pathway. It functions by recruiting the splicing factor SRSF10, which in turn downregulates IRF1—a transcriptional activator of Act1, a critical adaptor in IL-17A signaling. Notably, a psoriasis-susceptible variant of TRAF3IP2‐AS1 (A4165G, rs13210247) represents a gain‐of‐function mutation, and its murine homolog can similarly regulate Act1 expression. These findings highlight TRAF3IP2‐AS1 as a potential therapeutic target for IL-17-mediated conditions such as psoriasis and multiple sclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nIn cervical cancer, TRAF3IP2‐AS1 is significantly downregulated in patient serum, distinguishing cervical cancer cases from premalignant lesions and healthy individuals. Functional studies indicate that increased expression of TRAF3IP2‐AS1 suppresses cell proliferation, migration, and invasion by acting as a molecular sponge for miR-3677-3p, thereby exerting a tumor-suppressive effect. These results suggest that TRAF3IP2‐AS1 holds promise not only as a diagnostic biomarker but also as a novel therapeutic target in cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Yang, Yi Chen, Ning Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-methyladenosine of PARP1 mRNA and downregulating PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-021-01059-5"}], "href": "https://doi.org/10.1186/s13045-021-01059-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33741027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33741027"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ruirui He, Songfang Wu, Ru Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TRAF3IP2-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2001223"}], "href": "https://doi.org/10.4049/jimmunol.2001223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33941656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33941656"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chuncui Luo, Xixia Pang "}, {"type": "b", "children": [{"type": "t", "text": "IncRNA TRAF3IP2-AS1 Restrains Cervical Cancer Progression by Sponging miR-3677-3p and Acts As a Diagnostic Marker in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022044035"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022044035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36374810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36374810"}]}]}]}