TRAPPC14 Gene

Name trafficking protein particle complex subunit 14
Description Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRAPPC14, formerly known as C7orf43, is a TRAPPII-specific component that plays a crucial regulatory role during ciliogenesis. It mediates the targeting of the guanine nucleotide exchange factor Rabin8 to the preciliary centrosome, a necessary step for activating Rab8 and initiating ciliary membrane extension. Notably, TRAPPC14 facilitates the association of Rabin8 with the TRAPPII complex without being essential for the complex’s overall integrity. Additionally, TRAPPC14 directly interacts with distal appendage proteins such as FBF1 and CEP83, a connection that proves vital for tethering preciliary vesicles to the mother centriole, thereby ensuring effective cilium formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adrian Cuenca, Christine Insinna, Huijie Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.008615"}], "href": "https://doi.org/10.1074/jbc.RA119.008615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31467083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31467083"}]}]}]}
NCBI Gene ID 55262
API
Download Associations
Predicted Functions View TRAPPC14's ARCHS4 Predicted Functions.
Co-expressed Genes View TRAPPC14's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TRAPPC14's ARCHS4 Predicted Functions.

Functional Associations

TRAPPC14 has 1,508 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for TRAPPC14 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TRAPPC14 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of TRAPPC14 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
ClinVar Gene-Phenotype Associations 2025 phenotypes associated with TRAPPC14 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of TRAPPC14 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing TRAPPC14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing TRAPPC14 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with TRAPPC14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving TRAPPC14 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2025 cellular components containing TRAPPC14 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by TRAPPC14 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of TRAPPC14 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with TRAPPC14 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of TRAPPC14 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of TRAPPC14 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of TRAPPC14 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of TRAPPC14 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of TRAPPC14 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of TRAPPC14 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of TRAPPC14 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of TRAPPC14 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with TRAPPC14 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.