| HGNC Family | T cell receptors (TR) |
| Name | T cell receptor beta locus |
| Description | T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008] |
| Synonyms | TCRB, TRB@ |
| NCBI Gene ID | 6957 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TRB has 627 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.
Click the + buttons to view associations for TRB from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Biocarta Pathways | pathways involving TRB protein from the Biocarta Pathways dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TRB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| GAD Gene-Disease Associations | diseases associated with TRB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with TRB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TRB gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with TRB gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for TRB from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with TRB gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TRB gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TRB from the Pathway Commons Protein-Protein Interactions dataset. | |
