TRBC2 Gene

HGNC Family	T cell receptors (TR)
Name	T cell receptor beta constant 2
Description	Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	TCRBC2
Proteins	TRBC2_HUMAN
NCBI Gene ID	28638
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRBC2 has 694 functional associations with biological entities spanning 6 categories (organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 22 datasets.

Click the + buttons to view associations for TRBC2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRBC2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRBC2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRBC2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRBC2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRBC2 gene from the CellMarker Gene-Cell Type Associations dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRBC2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRBC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRBC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TRBC2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of TRBC2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations 2023	biological processes involving TRBC2 gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Cellular Component Annotations 2023	cellular components containing TRBC2 protein from the curated GO Cellular Component Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of TRBC2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRBC2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of TRBC2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with TRBC2 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of TRBC2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with TRBC2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.