HGNC Family | Immunoglobulin superfamily domain containing |
Name | triggering receptor expressed on myeloid cells-like 1 |
Description | This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTREML1, commonly referred to as TLT‐1, is a member of the triggering receptor expressed on myeloid cells (TREM) family that is uniquely expressed in platelets and megakaryocytes. Its extracellular region comprises a single immunoglobulin‐like V‐set domain, and its cytoplasmic tail contains immunoreceptor tyrosine‐based inhibitory motifs (ITIMs) (with splice variants that lack these motifs), endowing it with the potential to modulate intracellular signals in a non‐classical, co‐stimulatory manner. TLT‐1 is stored in platelet α‐granules and is rapidly translocated to the platelet surface upon activation. In addition, a soluble form of the receptor (sTLT‐1) is released during platelet activation, with structural studies revealing homology to related immunoglobulin receptors, further indicating an autonomous functional role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, TLT‐1 plays a critical role in hemostasis and the regulation of inflammation. By binding fibrinogen, it facilitates platelet aggregation at sites of vascular injury, a function underscored in sepsis models where elevated levels of sTLT‐1 correlate with disseminated intravascular coagulation and improved survival when administered therapeutically. Moreover, studies in TLT‐1 knockout mice and patients with platelet disorders demonstrate that deficiency in TLT‐1 impairs platelet aggregation and prolongs bleeding times while exacerbating inflammatory cytokine production, suggesting that TLT‐1 serves a protective role by dampening excessive leukocyte activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in platelet function, TLT‐1 has been implicated in a spectrum of inflammatory and thrombotic disorders. Variants in the TREM gene cluster have been linked to diseases such as Alzheimer’s, while elevated TLT‐1 expression and its soluble form have been associated with atherosclerosis, acute coronary syndromes, and preeclampsia. Proteomic mapping has identified several interactors—including integrins, adaptor proteins, and kinases—that connect TLT‐1 to broader signaling pathways involved in cell adhesion, migration, and cytokine production. TLT‐1 also participates in platelet–monocyte aggregate formation in conditions such as tuberculosis and severe burns, and its deficiency has been associated with preterm birth and impaired vascular responses, collectively underscoring its importance as an endogenous regulator of inflammation and thrombosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jill W Ford, Daniel W McVicar "}, {"type": "b", "children": [{"type": "t", "text": "TREM and TREM-like receptors in inflammation and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.coi.2009.01.009"}], "href": "https://doi.org/10.1016/j.coi.2009.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19230638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19230638"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander D Barrow, Emmanuelle Astoul, Andres Floto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.10.5838"}], "href": "https://doi.org/10.4049/jimmunol.172.10.5838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15128762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15128762"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Valance Washington, Laura Quigley, Daniel W McVicar "}, {"type": "b", "children": [{"type": "t", "text": "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-02-0523"}], "href": "https://doi.org/10.1182/blood-2002-02-0523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393607"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "James L Gattis, A Valance Washington, Maia M Chisholm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600489200"}], "href": "https://doi.org/10.1074/jbc.M600489200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16505478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16505478"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christopher W Smith, Zaher Raslan, Lola Parfitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2018017756"}], "href": "https://doi.org/10.1182/bloodadvances.2018017756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30120105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30120105"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "A Valance Washington, Sébastien Gibot, Ismael Acevedo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI36175"}], "href": "https://doi.org/10.1172/JCI36175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19436112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19436112"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marc Derive, Youcef Bouazza, Nacira Sennoun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102674"}], "href": "https://doi.org/10.4049/jimmunol.1102674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22551551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22551551"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jessica Morales, Karina Villa, Jim Gattis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Coagul Fibrinolysis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MBC.0b013e3283358116"}], "href": "https://doi.org/10.1097/MBC.0b013e3283358116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20093931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20093931"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Barbara Giomarelli, Valance A Washington, Maia M Chisholm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17549298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17549298"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Minerva M Carrasquillo, Mariet Allen, Jeremy D Burgess, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Dement (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jalz.2016.10.005"}], "href": "https://doi.org/10.1016/j.jalz.2016.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27939925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27939925"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ana C Glembotsky, Dominika Sliwa, Dominique Bluteau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2018.188904"}], "href": "https://doi.org/10.3324/haematol.2018.188904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545930"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anna M Schmoker, Leishla M Perez Pearson, Claudia Cruz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defining the TLT-1 interactome from resting and activated human platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2020.103638"}], "href": "https://doi.org/10.1016/j.jprot.2020.103638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31923473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31923473"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Omar L Esponda, Robert Hunter, José R Rivera Del Río, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Appl Thromb Hemost (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1076029614547298"}], "href": "https://doi.org/10.1177/1076029614547298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25147325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25147325"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "C-C Shu, L-N Lee, M-F Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Tuberc Lung Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5588/ijtld.10.0786"}], "href": "https://doi.org/10.5588/ijtld.10.0786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22283904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22283904"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Apabrita Ayan Das, Devasmita Chakravarty, Debmalya Bhunia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20190999"}], "href": "https://doi.org/10.1042/CS20190999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31713591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31713591"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Manni Wang, Xingyu Li, Qiaohua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2001218"}], "href": "https://doi.org/10.4049/jimmunol.2001218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35277419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35277419"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Paola E Peña-Garcia, Jessica Morales-Ortiz, Jean Marrero-Polanco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/aji.13772"}], "href": "https://doi.org/10.1111/aji.13772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37766406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37766406"}]}]}]}
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Synonyms | PRO3438, TLT-1, DJ238O23.3, GLTL1825, TLT1 |
Proteins | TRML1_HUMAN |
NCBI Gene ID | 340205 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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TREML1 has 2,434 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 79 datasets.
Click the + buttons to view associations for TREML1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TREML1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TREML1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TREML1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TREML1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TREML1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TREML1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TREML1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TREML1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with TREML1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TREML1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of TREML1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TREML1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TREML1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TREML1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TREML1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TREML1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TREML1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with TREML1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with TREML1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by TREML1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TREML1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TREML1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TREML1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with TREML1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with TREML1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TREML1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TREML1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of TREML1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TREML1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with TREML1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TREML1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TREML1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding TREML1 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving TREML1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving TREML1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing TREML1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing TREML1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TREML1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TREML1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TREML1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of TREML1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of TREML1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of TREML1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TREML1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for TREML1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with TREML1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with TREML1 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for TREML1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TREML1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate TREML1 protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TREML1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with TREML1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TREML1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing TREML1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TREML1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TREML1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TREML1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TREML1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by TREML1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of TREML1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NURSA Protein Complexes | protein complexs containing TREML1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for TREML1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TREML1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving TREML1 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2024 | pathways involving TREML1 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TREML1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TREML1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TREML1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of TREML1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TREML1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TREML1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TREML1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TREML1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TREML1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |