{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, TRG‑AS1 is significantly upregulated and correlates with poor patient prognosis. Functionally, it enhances tumor cell proliferation by acting as a competing endogenous RNA (ceRNA) that sequesters miR‑877‑5p, thereby relieving its inhibitory effect on SUZ12 expression. This mechanism underscores its oncogenic role in glioblastoma progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, studies in breast cancer, particularly in the context of bone metastasis, reveal that TRG‑AS1 expression is downregulated. Here, TRG‑AS1 functions as a tumor suppressor by competitively binding miR‑877‑5p to upregulate WISP2 expression, which in turn reduces cell proliferation, invasion, and disrupts the pro‐osteolytic signaling involved in metastasis. This suggests that TRG‑AS1 helps inhibit the progression of breast cancer bone metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, in colorectal cancer, TRG‑AS1—together with its co‑expressed gene P2RY10—has been identified as an important player in disease occurrence and development. Although detailed mechanistic insights in this setting remain to be fully elucidated, these findings further support the multifaceted role of TRG‑AS1 in cancer biology by potentially influencing gene regulatory networks across different tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haishu Xie, Songsheng Shi, Quan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TRG-AS1 promotes glioblastoma cell proliferation by competitively binding with miR-877-5p to regulate SUZ12 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2019.152476"}], "href": "https://doi.org/10.1016/j.prp.2019.152476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31196742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31196742"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinxiang Zhu, Hao Dai, Xiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.154360"}], "href": "https://doi.org/10.1016/j.prp.2023.154360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36801505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36801505"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Longqing Shi, Baoyang Luo, Linghui Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Gastroenterol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00365521.2024.2318363"}], "href": "https://doi.org/10.1080/00365521.2024.2318363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38357893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38357893"}]}]}]}