{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that the long noncoding RNA TRIM52‐AS1 plays multifaceted roles in oncogenesis through distinct molecular mechanisms. In hepatocellular carcinoma, TRIM52‐AS1 is upregulated in tumor tissues and cell lines, and its silencing was found to attenuate cell proliferation, migration, invasion, and epithelial‐to‐mesenchymal transition while suppressing tumor growth in vivo. Mechanistically, TRIM52‐AS1 acts as a molecular sponge for miR‑514a‑5p, thereby relieving the repression on its target MRPS18A, which in turn facilitates HCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cervical cancer, particularly in cells resistant to cisplatin (DDP), TRIM52‐AS1 is downregulated, a change that is associated with enhanced chemoresistance. Here, miR‑96‑5p is upregulated and directly binds to TRIM52‐AS1, further reducing its expression. Under normal conditions, TRIM52‐AS1 interacts with and suppresses the expression of IGF2BP2, a protein whose overexpression contributes to DDP resistance. Inhibition of miR‑96‑5p leads to an upregulation of TRIM52‐AS1, decreased IGF2BP2 levels, increased apoptosis, and reduced proliferation in DDP‐treated cells, thereby mitigating drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in diffuse large B cell lymphoma (DLBCL), TRIM52‐AS1 is markedly overexpressed and correlates with advanced clinical features such as poor Ann Arbor stage, presence of B symptoms, and high international prognostic index scores, ultimately predicting an unfavorable prognosis. Functional assays reveal that knockdown of TRIM52‐AS1 impairs DLBCL cell proliferation, induces apoptosis, and triggers G0/G1 phase arrest. At the molecular level, TRIM52‐AS1 enhances the stability of TRIM52 mRNA by binding to IGFBP3 and by acting as a sponge for miR‑577 (or related miRNAs), thereby upregulating TRIM52 expression and promoting lymphomagenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chunhui Zhou, Zhen Chen, Changli Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2019.3271"}], "href": "https://doi.org/10.1089/cbr.2019.3271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32391716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32391716"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "En Yuesu Wu, Li-Ping Huang, Jin-Hua Bao "}, {"type": "b", "children": [{"type": "t", "text": "miR-96-5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52-AS1 and promoting IGF2BP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12593"}], "href": "https://doi.org/10.1002/kjm2.12593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36354205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36354205"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fang Zhao, Shucheng Li, Jingjing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00725-1"}], "href": "https://doi.org/10.1007/s13577-022-00725-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35676608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35676608"}]}]}]}