TRIOBP Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH)
Name	TRIO and F-actin binding protein
Description	This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIOBP, also known as Tara, is a multifaceted F‐actin binding protein that plays a central role in maintaining the integrity of sensory and non‐sensory cells. In the inner ear, long isoforms of TRIOBP (particularly TRIOBP‐4 and TRIOBP‐5) are necessary for bundling actin filaments into robust stereocilia rootlets, a process that is crucial for proper mechanotransduction and normal auditory function. Disruptive mutations—including nonsense and frameshift variants in key actin‐binding regions (such as repeat domains R1 and R2)—have been identified as the genetic basis of autosomal recessive nonsyndromic deafness (DFNB28) in multiple families, and common sequence variants have further been associated with age‐related hearing loss."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in hearing, TRIOBP is a key regulator of actin cytoskeletal dynamics that impacts diverse cellular processes. By organizing and stabilizing F‐actin structures, TRIOBP modulates cell shape, migration, and division. Its activity is finely tuned by protein–protein interactions and post‐translational modifications: for instance, binding to Ndel1 facilitates enhanced filopodia formation and cell motility, while phosphorylation by Polo‐like kinase 1 and ubiquitination by HECTD3 regulate its centrosomal localization and turnover during mitosis. Aberrant aggregation of the TRIOBP‐1 isoform—involving a specific central coiled‐coil region—has been implicated in the neuropathology of chronic mental illnesses such as schizophrenia and major depressive disorder. In addition, dysregulated TRIOBP expression contributes to altered cellular behaviors in other disease contexts, affecting cardiac excitability through hERG channel interactions, promoting cancer cell motility, and even modulating pathological epithelial–mesenchymal crosstalk in pulmonary fibrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Saima Riazuddin, Shaheen N Khan, Zubair M Ahmed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/499164"}], "href": "https://doi.org/10.1086/499164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16385457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16385457"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hashem Shahin, Tom Walsh, Tama Sobe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/499495"}], "href": "https://doi.org/10.1086/499495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16385458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16385458"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006371"}], "href": "https://doi.org/10.1371/journal.pgen.1006371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27764096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27764096"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mieke Wesdorp, Jiddeke M van de Kamp, Erik F Hensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Broadening the phenotype of DFNB28: Mutations in TRIOBP are associated with moderate, stable hereditary hearing impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hear Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.heares.2016.12.017"}], "href": "https://doi.org/10.1016/j.heares.2016.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28089734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28089734"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rosemary Ida Kabahuma, Wolf-Dieter Schubert, Christiaan Labuschagne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.2015"}], "href": "https://doi.org/10.1002/mgg3.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36029164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36029164"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jian Yu, Jianping Lan, Yuanyuan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.01.022"}], "href": "https://doi.org/10.1016/j.bbrc.2008.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18194665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18194665"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Valentina Appierto, Paola Tiberio, Elena Cavadini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-09-0798"}], "href": "https://doi.org/10.1158/1535-7163.MCT-09-0798"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19996280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19996280"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuanyuan Zhu, Chong Wang, Jianping Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2012.07.001"}], "href": "https://doi.org/10.1016/j.yexcr.2012.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22820163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22820163"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jianjun Bao, Shuo Wang, Laura K Gunther, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The actin-bundling protein TRIOBP-4 and -5 promotes the motility of pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.08.005"}], "href": "https://doi.org/10.1016/j.canlet.2014.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25130170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25130170"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nicholas J Bradshaw, Verian Bader, Ingrid Prikulis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0111196"}], "href": "https://doi.org/10.1371/journal.pone.0111196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25333879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25333879"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ji-Ho Hong, Yongdo Kwak, Youngsik Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep31827"}], "href": "https://doi.org/10.1038/srep31827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27546710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27546710"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nicholas J Bradshaw, Antony S K Yerabham, Rita Marreiros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.767939"}], "href": "https://doi.org/10.1074/jbc.M116.767939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28438837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28438837"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Agnieszka Pollak, Urszula Lechowicz, Victor Abel Murcia Pieńkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole exome sequencing identifies TRIOBP pathogenic variants as a cause of post-lingual bilateral moderate-to-severe sensorineural hearing loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12881-017-0499-z"}], "href": "https://doi.org/10.1186/s12881-017-0499-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29197352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29197352"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "David K Jones, Ashley C Johnson, Elon C Roti Roti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.206730"}], "href": "https://doi.org/10.1242/jcs.206730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29507111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29507111"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sungjin Park, Hyunji Lee, Minhee Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatr Danub (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.24869/psyd.2023.180"}], "href": "https://doi.org/10.24869/psyd.2023.180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37480305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37480305"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Lan Wang, Wenyu Zhao, Cong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-023-05080-4"}], "href": "https://doi.org/10.1007/s00018-023-05080-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38157020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38157020"}]}]}]}
Synonyms	TARA, TAP68, DFNB28, HRIHFB2122, DJ37E16.4
Proteins	TARA_HUMAN
NCBI Gene ID	11078
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIOBP has 6,404 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 135 datasets.

Click the + buttons to view associations for TRIOBP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIOBP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIOBP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIOBP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIOBP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIOBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIOBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIOBP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIOBP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIOBP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIOBP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRIOBP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIOBP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIOBP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIOBP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIOBP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIOBP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIOBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIOBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TRIOBP gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TRIOBP gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIOBP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIOBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIOBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRIOBP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIOBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIOBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIOBP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIOBP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRIOBP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRIOBP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TRIOBP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIOBP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TRIOBP gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TRIOBP gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRIOBP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIOBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIOBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIOBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRIOBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRIOBP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIOBP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.