TRPM6 Gene

HGNC Family	Ion channels
Name	transient receptor potential cation channel, subfamily M, member 6
Description	This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRPM6 is an epithelial magnesium channel–kinase that plays an essential role in whole‐body Mg²⁺ homeostasis by mediating transepithelial magnesium absorption in the intestine and reabsorption in the renal distal convoluted tubule. Mutations in TRPM6 cause autosomal recessive hypomagnesemia with secondary hypocalcemia, as demonstrated by studies mapping disease‐causing mutations to the TRPM6 gene and showing that loss of channel function leads to impaired intestinal magnesium uptake and renal conservation of magnesium."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its basic channel activity, TRPM6 exhibits unique biophysical characteristics that depend on its ability to form both homomeric channels and heteromeric complexes with its closest homolog TRPM7. Functional studies have revealed that wild‐type TRPM6 generates a Mg²⁺– and Ca²⁺–permeable cation conductance regulated by intracellular Mg²⁺ levels, whereas disease‐associated mutations (such as S141L) disrupt channel assembly and function. In addition, TRPM6 activity is modulated by several signaling pathways – for example, EGF stimulation increases TRPM6 channel activity via a Src/Rac1-dependent redistribution to the plasma membrane, and insulin signaling triggers TRPM6 upregulation through a PI3K–Rac1 pathway. These findings underscore cooperative interactions and interdependence between TRPM6 and TRPM7, as TRPM6 is necessary for proper TRPM7 surface expression and heteromer formation, and both channels appear to have distinct as well as nonredundant roles in cellular magnesium handling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, emerging evidence implicates TRPM6 regulation in diverse physiological and pathological contexts. Altered expression and genetic variations near TRPM6 influence serum magnesium levels and may affect risk for metabolic disorders such as type 2 and gestational diabetes. Other regulatory mechanisms—including control by phosphatidylinositol-4,5-bisphosphate, modulation through interactions with proteins like REA and calmodulin, and direct transcriptional control by factors such as FXR—further fine-tune TRPM6 function. In intestinal and renal cells as well as even in cardiac tissues, this dynamic regulation of TRPM6 impacts not only magnesium homeostasis but may also modulate cell proliferation, vascular tone, and chemotherapy responses in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karl P Schlingmann, Stefanie Weber, Melanie Peters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng889"}], "href": "https://doi.org/10.1038/ng889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12032568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12032568"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Thomas Voets, Bernd Nilius, Susan Hoefs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311201200"}], "href": "https://doi.org/10.1074/jbc.M311201200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14576148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14576148"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Roxanne Y Walder, Daniel Landau, Peter Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng901"}], "href": "https://doi.org/10.1038/ng901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12032570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12032570"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gary A Quamme "}, {"type": "b", "children": [{"type": "t", "text": "Recent developments in intestinal magnesium absorption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Gastroenterol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MOG.0b013e3282f37b59"}], "href": "https://doi.org/10.1097/MOG.0b013e3282f37b59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18301276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18301276"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vladimir Chubanov, Thomas Gudermann, Karl P Schlingmann "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-005-1470-y"}], "href": "https://doi.org/10.1007/s00424-005-1470-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16075242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16075242"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mingjiang Li, Jianmin Jiang, Lixia Yue "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1085/jgp.200609502"}], "href": "https://doi.org/10.1085/jgp.200609502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16636202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16636202"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vladimir Chubanov, Siegfried Waldegger, Michael Mederos y Schnitzler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0305252101"}], "href": "https://doi.org/10.1073/pnas.0305252101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14976260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14976260"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tamra E Meyer, Germaine C Verwoert, Shih-Jen Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1001045"}], "href": "https://doi.org/10.1371/journal.pgen.1001045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20700443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20700443"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Carsten Schmitz, Maxim V Dorovkov, Xiaoyun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The channel kinases TRPM6 and TRPM7 are functionally nonredundant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M509175200"}], "href": "https://doi.org/10.1074/jbc.M509175200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16150690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16150690"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rhian M Touyz "}, {"type": "b", "children": [{"type": "t", "text": "Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00903.2007"}], "href": "https://doi.org/10.1152/ajpheart.00903.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18192217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18192217"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Stéphanie Thebault, R Todd Alexander, Wouter M Tiel Groenestege, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGF increases TRPM6 activity and surface expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2008030327"}], "href": "https://doi.org/10.1681/ASN.2008030327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19073827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19073827"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anil V Nair, Berthold Hocher, Sjoerd Verkaart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1113811109"}], "href": "https://doi.org/10.1073/pnas.1113811109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22733750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22733750"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kristopher Clark, Jeroen Middelbeek, Nick A Morrice, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0001876"}], "href": "https://doi.org/10.1371/journal.pone.0001876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18365021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18365021"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sara Castiglioni, Alessandra Cazzaniga, Valentina Trapani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep16538"}], "href": "https://doi.org/10.1038/srep16538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26563869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26563869"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Federica I Wolf, Valentina Trapani "}, {"type": "b", "children": [{"type": "t", "text": "Magnesium and its transporters in cancer: a novel paradigm in tumour development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20120086"}], "href": "https://doi.org/10.1042/CS20120086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22671428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22671428"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alexander Dietrich, Vladimir Chubanov, Thomas Gudermann "}, {"type": "b", "children": [{"type": "t", "text": "Renal TRPathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2009090948"}], "href": "https://doi.org/10.1681/ASN.2009090948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20395377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20395377"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Francesca Luongo, Giuseppe Pietropaolo, Mathieu Gautier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutrients (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/nu10060784"}], "href": "https://doi.org/10.3390/nu10060784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29912157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29912157"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Grigory Krapivinsky, Luba Krapivinsky, Nora E Renthal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1708427114"}], "href": "https://doi.org/10.1073/pnas.1708427114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28784805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28784805"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Inga Andriulė, Dalia Pangonytė, Mantė Almanaitytė, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25709"}], "href": "https://doi.org/10.1002/jcp.25709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27925186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27925186"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Andrew Y Shuen, Betty Y L Wong, Cuihong Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic determinants of extracellular magnesium concentration: analysis of multiple candidate genes, and evidence for association with the estrogen receptor alpha (ESR1) locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2009.08.007"}], "href": "https://doi.org/10.1016/j.cca.2009.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19695239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19695239"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Eun Young Kim, Jae Man Lee "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional Control of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Trpm6"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " by the Nuclear Receptor FXR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23041980"}], "href": "https://doi.org/10.3390/ijms23041980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35216094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35216094"}]}]}]}
Synonyms	HOMG, HSH, HMGX, CHAK2, HOMG1
Proteins	TRPM6_HUMAN
NCBI Gene ID	140803
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRPM6 has 5,391 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for TRPM6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRPM6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TRPM6 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPM6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPM6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRPM6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRPM6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRPM6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPM6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRPM6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRPM6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRPM6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRPM6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRPM6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRPM6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TRPM6 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRPM6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRPM6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRPM6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRPM6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TRPM6 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TRPM6 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRPM6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRPM6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRPM6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRPM6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRPM6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TRPM6 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRPM6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRPM6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRPM6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRPM6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TRPM6 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRPM6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TRPM6 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRPM6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRPM6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRPM6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRPM6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRPM6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRPM6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRPM6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.