| Name | testis expressed basic protein 1 |
| Description | Located in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
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In summary, while these works offer extensive insight into how astrocyte–neuron signaling and glutamate homeostasis impact neuronal viability and synaptic function, they do not provide any evidence or discussion pertaining to TSBP1.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Schmitt, E Asan, K-P Lesch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0306-4522(01)00451-1"}], "href": "https://doi.org/10.1016/s0306-4522(01"}, {"type": "t", "text": "00451-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11784699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11784699"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P F Behrens, P Franz, B Woodman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awf180"}], "href": "https://doi.org/10.1093/brain/awf180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12135980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12135980"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Paikan Marcaggi, Daniela Billups, David Attwell "}, {"type": "b", "children": [{"type": "t", "text": "The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2003.044263"}], "href": "https://doi.org/10.1113/jphysiol.2003.044263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12878755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12878755"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Akira Mitani, Kohichi Tanaka "}, {"type": "b", "children": [{"type": "t", "text": "Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12904478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12904478"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong Guo, Liching Lai, Matthew E R Butchbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg267"}], "href": "https://doi.org/10.1093/hmg/ddg267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12915461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12915461"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthew E R Butchbach, Guilian Tian, Hong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403938200"}], "href": "https://doi.org/10.1074/jbc.M403938200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15187084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15187084"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianzheng Zhou, Margaret L Sutherland "}, {"type": "b", "children": [{"type": "t", "text": "Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1404-04.2004"}], "href": "https://doi.org/10.1523/JNEUROSCI.1404-04.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15254085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15254085"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Deepa V Dabir, Michael B Robinson, Eric Swanson, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Caspase-3 cleaves and inactivates the glutamate transporter EAAT2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600653200"}], "href": "https://doi.org/10.1074/jbc.M600653200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16567804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16567804"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "B R Miller, J L Dorner, M Shou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2008.02.004"}], "href": "https://doi.org/10.1016/j.neuroscience.2008.02.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18353560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18353560"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chihiro Takasaki, Rieko Okada, Akira Mitani, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2008.08.043"}], "href": "https://doi.org/10.1016/j.neuroscience.2008.08.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18805467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18805467"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yongjie Yang, Oguz Gozen, Andrew Watkins, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2011-110503"}], "href": "https://doi.org/10.3233/JAD-2011-110503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21677376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21677376"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Julien Ratelade, Jeffrey L Bennett, A S Verkman "}, {"type": "b", "children": [{"type": "t", "text": "Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.297275"}], "href": "https://doi.org/10.1074/jbc.M111.297275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22069320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22069320"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hao Wu, Fengli Wang, Shenglan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2012.07.001"}], "href": "https://doi.org/10.1016/j.cellsig.2012.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22781751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22781751"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Moonnoh R Lee, Christina L Ruby, David J Hinton, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Amyloid-β1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5274-12.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.5274-12.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23516295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23516295"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ying Zhang, Lei Yang, Yuan-Fu Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2013.08.004"}], "href": "https://doi.org/10.1016/j.mce.2013.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23954742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23954742"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Wanpeng Cui, Hiroaki Mizukami, Michiko Yanagisawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1465-14.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.1465-14.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25471567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25471567"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Geraldine T Petr, Yan Sun, Natalie M Frederick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4255-14.2015"}], "href": "https://doi.org/10.1523/JNEUROSCI.4255-14.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25834045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25834045"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Aditi Falnikar, Tamara J Hala, David J Poulsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.22936"}], "href": "https://doi.org/10.1002/glia.22936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26496514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26496514"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.expneurol.2016.05.003"}], "href": "https://doi.org/10.1016/j.expneurol.2016.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27155358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27155358"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Tao Fang, Qianqian Wu, Long Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2016.07.010"}], "href": "https://doi.org/10.1016/j.yexcr.2016.07.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27426726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27426726"}]}]}]}
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| NCBI Gene ID | 10665 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TSBP1 has 1,242 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.
Click the + buttons to view associations for TSBP1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of TSBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TSBP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TSBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving TSBP1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TSBP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TSBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TSBP1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TSBP1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TSBP1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TSBP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TSBP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of TSBP1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TSBP1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TSBP1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TSBP1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TSBP1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TSBP1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |