TSPAN13 Gene

HGNC Family	Tetraspanins (TSPAN)
Name	tetraspanin 13
Description	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nInitial gene expression profiling in breast cancer cells identified TSPAN13 as one of several membrane proteins differentially expressed between HER2‐positive and HER2‐negative tumors, suggesting a potential involvement in mammary neoplasia. This early observation provided the rationale for further investigations into the possible roles of TSPAN13 in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn papillary thyroid carcinoma, downregulation of miR‐369-3p relieves its inhibitory effect on TSPAN13, resulting in TSPAN13 upregulation. This molecular alteration has been associated with more aggressive clinical behavior and shorter overall survival in patients, implicating TSPAN13 as a contributor to thyroid tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nProstate cancer studies have demonstrated that TSPAN13 is overexpressed in a substantial proportion of tumor samples, with its expression inversely correlating with unfavorable prognostic markers such as higher Gleason scores and elevated preoperative PSA levels. Moreover, the diagnostic utility of the TSPAN13-to-S100A9 expression ratio highlights its potential as a non-invasive biomarker for distinguishing malignant from benign prostatic tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of breast cancer, additional studies have focused on NET-6—another alias for TSPAN13—and its functional modulation. Ectopic expression experiments in aggressive breast carcinoma cell lines suggest that TSPAN13 may act as a tumor suppressor. In contrast, microRNA-mediated downregulation (for example, via miR-4732-5p) promotes proliferation, migration, and invasion, illustrating a dual role that is context-dependent. Higher expression of TSPAN13 in less aggressive, HER2-negative, low-grade tumors further supports its association with favorable phenotypic traits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary evidence from studies on telomerase regulation and pediatric gliomas reinforces the multifaceted role of TSPAN13 in cancer. In telomerase-overexpressing osteosarcoma cells, TSPAN13 knockdown enhanced apoptosis and shifted cellular properties toward a more epithelial phenotype, underscoring its regulatory influence on cell survival and differentiation. Similarly, increased expression of TSPAN13 in pediatric gliomas, alongside other proliferation- and survival-related genes, suggests a contributory role in tumor growth through dysregulation of cell proliferation and apoptotic mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huayi Huang, Jeff Groth, Khalid Sossey-Alaoui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-04-2107"}], "href": "https://doi.org/10.1158/1078-0432.CCR-04-2107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15958618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15958618"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peng Li, Mingqiang Dong, Zhigang Wang "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bosn J Basic Med Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bjbms.2018.2865"}], "href": "https://doi.org/10.17305/bjbms.2018.2865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30114378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30114378"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jose M Arencibia, Susana Martín, Francisco J Pérez-Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19148481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19148481"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chunri Yan, Ye-Hwan Kim, Ho Won Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Korean Med Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3346/jkms.2015.30.12.1784"}], "href": "https://doi.org/10.3346/jkms.2015.30.12.1784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26713053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26713053"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Huayi Huang, Khalid Sossey-Alaoui, Sarah H Beachy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tetraspanin superfamily member NET-6 is a new tumor suppressor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-007-0221-1"}], "href": "https://doi.org/10.1007/s00432-007-0221-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17486367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17486367"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ya-Wen Wang, Song Zhao, Xun-Yi Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4732-5p promotes breast cancer progression by targeting TSPAN13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14145"}], "href": "https://doi.org/10.1111/jcmm.14145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30701690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30701690"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liejun Jiang, Xiliu Zhang, Joseph Geradts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of tetraspanins NET-6 and CD151 in breast cancer as a potential tumor biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-019-00554-x"}], "href": "https://doi.org/10.1007/s10238-019-00554-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31004251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31004251"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rishi K Jaiswal, Pramod Kumar, Manoj Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hTERT promotes tumor progression by enhancing TSPAN13 expression in osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22824"}], "href": "https://doi.org/10.1002/mc.22824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29722072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29722072"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "D O Minchenko, Y E Novik, H S Maslak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lik Sprava (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27491149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27491149"}]}]}]}
Synonyms	NET-6, NET6, TM4SF13
Proteins	TSN13_HUMAN
NCBI Gene ID	27075
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TSPAN13 has 10,764 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for TSPAN13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TSPAN13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TSPAN13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TSPAN13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TSPAN13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TSPAN13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSPAN13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSPAN13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TSPAN13 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSPAN13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TSPAN13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TSPAN13 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TSPAN13 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TSPAN13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TSPAN13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TSPAN13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TSPAN13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TSPAN13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TSPAN13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSPAN13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TSPAN13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TSPAN13 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TSPAN13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TSPAN13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TSPAN13 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TSPAN13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TSPAN13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TSPAN13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TSPAN13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TSPAN13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TSPAN13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TSPAN13 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TSPAN13 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TSPAN13 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TSPAN13 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of TSPAN13 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of TSPAN13 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.