{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTSPOAP1-AS1, also known as BZRAP1-AS1, has recently emerged as an important long non‐coding RNA with multifaceted roles in disease pathology. In hepatocellular carcinoma, for instance, this lncRNA has been implicated in promoting angiogenesis, a process crucial for tumor growth and progression, while its dysregulation has also been associated with altered immune statuses in various cancers and neurodegenerative conditions such as Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nStudies in the context of sepsis further imply that long noncoding RNAs, including TSPOAP1-AS1, may participate in the systemic inflammatory responses observed in pediatric septic shock, although its precise mechanistic role in this syndrome remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n \nIn addition, epigenetic analyses have revealed that increased DNA methylation at the promoter region of TSPOAP1-AS1 is significantly correlated with overweight/obesity and adverse lipid profiles. These findings suggest a potential role for TSPOAP1-AS1 in metabolic regulation and highlight its possible utility as a biomarker for obesity risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Weiwei Wang, Guoyong Chen, Bing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA BZRAP1-AS1 silencing suppresses tumor angiogenesis in hepatocellular carcinoma by mediating THBS1 methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-02145-6"}], "href": "https://doi.org/10.1186/s12967-019-02145-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31847842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31847842"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Junsong Zhu, Shaoheng Tu, Qunwei Qu "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA BZRAP1-AS1 alleviates rheumatoid arthritis by regulating miR-1286/COL5A2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immun Inflamm Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iid3.558"}], "href": "https://doi.org/10.1002/iid3.558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34766472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34766472"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yong Wu, Qigai Yin, Xiaobao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/7170464"}], "href": "https://doi.org/10.1155/2020/7170464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33344646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33344646"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nam-Hui Yim, Min Ho Cha, Myung Sunny Kim "}, {"type": "b", "children": [{"type": "t", "text": "Hypermethylation of the TSPOAP1-AS1 Promoter May Be Associated with Obesity in Overweight/Obese Korean Subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21093307"}], "href": "https://doi.org/10.3390/ijms21093307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32392798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32392798"}]}]}]}