| Name | testis specific protein, Y-linked 3 |
| Description | Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided literature reveals that none of these studies address or mention any role for TSPY3. Instead, the abstracts collectively elaborate on a wide range of molecular functions—from the regulation of lipid metabolism and innate immune responses (via molecules such as CD36, lysosomal acid lipase, CH25H, and 25‐hydroxycholesterol) to mechanisms controlling cellular differentiation and migration (involving JAM family proteins, Id proteins, and transcriptional regulators such as Grainyhead‐like and PHF2). In addition, several studies describe antiviral pathways, mitochondrial protein import in neurodegeneration models, and even control of stem cell fate in both neural and spermatogenic lineages. Despite the broad mechanistic insights these reports offer, none provide data pertinent to TSPY3, leaving its function uncharacterized in this collection of studies. Consequently, no conclusions about the biochemical role or regulatory impact of TSPY3 can be drawn from these abstracts, and further dedicated investigation would be necessary to elucidate its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Georgia Gliki, Klaus Ebnet, Michel Aurrand-Lions, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.05-4196fje"}], "href": "https://doi.org/10.1096/fj.05-4196fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195363"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alana Auden, Jacinta Caddy, Tomasz Wilanowski, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Perturbed desmosomal cadherin expression in grainy head-like 1-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2008.24"}], "href": "https://doi.org/10.1038/emboj.2008.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18288204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18288204"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Peng Qu, Hong Du, David S Wilkes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles of lysosomal acid lipase in T cell development and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080562"}], "href": "https://doi.org/10.2353/ajpath.2009.080562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19179613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19179613"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ulf Diczfalusy, Katarina E Olofsson, Ann-Margreth Carlsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M900107-JLR200"}], "href": "https://doi.org/10.1194/jlr.M900107-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19502589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19502589"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "David R Bauman, Andrew D Bitmansour, Jeffrey G McDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0909142106"}], "href": "https://doi.org/10.1073/pnas.0909142106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19805370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19805370"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hong Wen, Jingzhi Li, Tanjing Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C109.097667"}], "href": "https://doi.org/10.1074/jbc.C109.097667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20129925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20129925"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Berna S Sayan, Ai Li Yang, Franco Conforti, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1014862107"}], "href": "https://doi.org/10.1073/pnas.1014862107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21078990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21078990"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Stephane Daffis, Kristy J Szretter, Jill Schriewer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09489"}], "href": "https://doi.org/10.1038/nature09489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21085181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21085181"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shih-Shih Chen, Rainer Claus, David M Lucas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-05-284638"}], "href": "https://doi.org/10.1182/blood-2010-05-284638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21098398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21098398"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Abigail Woodfin, Mathieu-Benoit Voisin, Martina Beyrau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2062"}], "href": "https://doi.org/10.1038/ni.2062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21706006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21706006"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Olivia Perwitasari, Hyelim Cho, Michael S Diamond, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.285205"}], "href": "https://doi.org/10.1074/jbc.M111.285205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22065572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22065572"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Volker Fensterl, Jaime L Wetzel, Srividya Ramachandran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1002712"}], "href": "https://doi.org/10.1371/journal.ppat.1002712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22615570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22615570"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Tangsheng Yi, Xiaoming Wang, Lisa M Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.06.015"}], "href": "https://doi.org/10.1016/j.immuni.2012.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22999953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22999953"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "D Lettieri Barbato, G Tatulli, K Aquilano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2013.404"}], "href": "https://doi.org/10.1038/cddis.2013.404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24136225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24136225"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Stanley Ching-Cheng Huang, Bart Everts, Yulia Ivanova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2956"}], "href": "https://doi.org/10.1038/ni.2956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25086775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25086775"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Andrea Reboldi, Eric V Dang, Jeffrey G McDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1254790"}], "href": "https://doi.org/10.1126/science.1254790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25104388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25104388"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Feng Sun, Qing Xu, Danfeng Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Id4 Marks Spermatogonial Stem Cells in the Mouse Testis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep17594"}], "href": "https://doi.org/10.1038/srep17594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26621350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26621350"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Deqing Wu, Yue Zeng, Yuting Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep20545"}], "href": "https://doi.org/10.1038/srep20545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26841848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26841848"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Matthew J Gorman, Subhajit Poddar, Michael Farzan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00581-16"}], "href": "https://doi.org/10.1128/JVI.00581-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27384652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27384652"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Aileen R Helsel, Qi-En Yang, Melissa J Oatley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ID4 levels dictate the stem cell state in mouse spermatogonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.146928"}], "href": "https://doi.org/10.1242/dev.146928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28087628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28087628"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Wan-Su Choi, Gyuseok Lee, Won-Hyun Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-019-0920-1"}], "href": "https://doi.org/10.1038/s41586-019-0920-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30728500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30728500"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Runrui Zhang, Marcelo Boareto, Anna Engler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.07.014"}], "href": "https://doi.org/10.1016/j.celrep.2019.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31390563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31390563"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Isabelle Maria Blomfield, Brenda Rocamonde, Maria Del Mar Masdeu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.48561"}], "href": "https://doi.org/10.7554/eLife.48561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31552825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31552825"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jennifer H Madenspacher, Eric D Morrell, Kymberly M Gowdy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.137189"}], "href": "https://doi.org/10.1172/jci.insight.137189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32343675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32343675"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Vy Tran, Mitchell P Ledwith, Thiprampai Thamamongood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-020-0778-x"}], "href": "https://doi.org/10.1038/s41564-020-0778-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32839537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32839537"}]}]}]}
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| Synonyms | CT78 |
| Proteins | TSPY3_HUMAN |
| NCBI Gene ID | 728137 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TSPY3 has 564 functional associations with biological entities spanning 6 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.
Click the + buttons to view associations for TSPY3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSPY3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TSPY3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TSPY3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TSPY3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TSPY3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TSPY3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TSPY3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TSPY3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPY3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TSPY3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TSPY3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TSPY3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TSPY3 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TSPY3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TSPY3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TSPY3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSPY3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing TSPY3 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TSPY3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TSPY3 from the Pathway Commons Protein-Protein Interactions dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TSPY3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TSPY3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TSPY3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TSPY3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TSPY3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |