TTC28-AS1 Gene

Name TTC28 antisense RNA 1
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into type 2 diabetes mellitus (T2DM) have revealed that the long noncoding RNA TTC28-AS1 is significantly down-regulated in patients compared to healthy controls. The decreased expression of TTC28-AS1 was shown to be an independent factor affecting T2DM susceptibility, with a positive correlation noted between its expression levels and low‐density lipoprotein cholesterol (LDL-C). This finding suggests that TTC28-AS1 may function as a regulator of metabolic processes involved in the onset and progression of T2DM."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Emerging evidence also implicates long noncoding RNAs in broader diabetic complications such as diabetic nephropathy, a primary cause of end‐stage renal disease. Although TTC28-AS1 has been directly linked to metabolic dysregulation in T2DM, the general role of lncRNAs in the pathogenesis of diabetic nephropathy underscores the potential for TTC28-AS1 to contribute to the multifaceted molecular mechanisms underlying diabetic organ damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mahroo Mohamadi, Hamid Ghaedi, Faranak Kazerouni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Clin Lab Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00365513.2019.1664760"}], "href": "https://doi.org/10.1080/00365513.2019.1664760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31509021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31509021"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ji Zhang, Juan Ding, Ming Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-021-01167-z"}], "href": "https://doi.org/10.1007/s13258-021-01167-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34623609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34623609"}]}]}]}
Synonyms TTC28-AS, TTC28AS
NCBI Gene ID 284900
API
Download Associations
Predicted Functions View TTC28-AS1's ARCHS4 Predicted Functions.
Co-expressed Genes View TTC28-AS1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TTC28-AS1's ARCHS4 Predicted Functions.

Functional Associations

TTC28-AS1 has 1,841 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 29 datasets.

Click the + buttons to view associations for TTC28-AS1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of TTC28-AS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of TTC28-AS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of TTC28-AS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with TTC28-AS1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TTC28-AS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of TTC28-AS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
dbGAP Gene-Trait Associations traits associated with TTC28-AS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TTC28-AS1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TTC28-AS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of TTC28-AS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing TTC28-AS1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of TTC28-AS1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of TTC28-AS1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TTC28-AS1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of TTC28-AS1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWASdb SNP-Disease Associations diseases associated with TTC28-AS1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with TTC28-AS1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of TTC28-AS1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TTC28-AS1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of TTC28-AS1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of TTC28-AS1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of TTC28-AS1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of TTC28-AS1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TTC28-AS1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.