TTTY4 Gene

Name testis-specific transcript, Y-linked 4 (non-protein coding)
Description There are three copies of this gene on chromosome Y. This record represents the most centromeric copy. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study investigating the genetic risk factors for chronic obstructive pulmonary disease in a southern Han Chinese population, the testis‐specific protein Y‐encoded‐like‐4 (TSPYL-4) gene was evaluated for its role in pulmonary function. Analysis of multiple single-nucleotide polymorphisms revealed that the rs3749893 A allele of TSPYL-4 was significantly associated with a protective effect against the deterioration of lung function. Although haplotype analysis involving TSPYL-4 did not demonstrate a significant difference between COPD cases and controls, the findings suggest that genetic variation in TSPYL-4 may contribute to modulating susceptibility to COPD by influencing pulmonary parameters. This protective association highlights the potential importance of TSPYL-4 polymorphisms in maintaining lung function in populations at risk for COPD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Guo, Yi Gong, Guochao Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2012.964"}], "href": "https://doi.org/10.3892/mmr.2012.964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22736055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22736055"}]}]}]}
Synonyms TTY4, LINC00123, TTTY4A, NCRNA00123
NCBI Gene ID 114761
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Predicted Functions View TTTY4's ARCHS4 Predicted Functions.
Co-expressed Genes View TTTY4's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TTTY4's ARCHS4 Predicted Functions.

Functional Associations

TTTY4 has 114 functional associations with biological entities spanning 5 categories (molecular profile, organism, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for TTTY4 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TTTY4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of TTTY4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TTTY4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of TTTY4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with TTTY4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of TTTY4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of TTTY4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TTTY4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.