TUFT1 Gene

Name	tuftelin 1
Description	Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTUFT1 was originally characterized for its role in dental enamel development and mineralization. Genetic and molecular studies have demonstrated that variation in TUFT1, along with other enamel matrix proteins, is associated with enamel defects such as molar–incisor hypomineralization and increased dental caries susceptibility. Moreover, its complex transcriptional regulation, alternative splicing, and conservation across mineralizing and non‐mineralizing tissues suggest that TUFT1 may serve multifunctional roles during tooth development as well as in other tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn recent years, TUFT1 has emerged as an oncogenic factor in a diverse range of tumors. Overexpression of TUFT1 has been documented in hepatocellular carcinoma, pancreatic cancer, triple-negative breast cancer, renal cell carcinoma, gastric cancer, and cervical cancer, where it promotes cell proliferation, migration, invasion, and epithelial–mesenchymal transition. Mechanistically, TUFT1 has been shown to activate the Ca2⁺/PI3K/AKT/mTOR pathway, modulate hypoxia‐related signaling via HIF1 and its downstream effectors, interact with key transcription factors such as CREB1, and function as part of competing endogenous RNA networks influenced by both microRNAs and long non‐coding RNAs. Its contribution to chemotherapy resistance, enhanced lipogenesis, and stemness further underscores its clinical relevance as a potential biomarker and therapeutic target in malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in dental and cancer biology, TUFT1 expression in non‐mineralizing tissues has functional consequences in other disease contexts. A nonsynonymous variant in TUFT1 has been implicated in familial early-onset osteoarthritis through impaired chondrogenic differentiation, altered extracellular matrix calcification, and reduced proteoglycan deposition. In addition, loss-of-function variants that affect TUFT1 expression and its localization to desmosomes are associated with skin fragility, woolly hair, and palmoplantar keratoderma, highlighting its importance in maintaining epidermal integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fabiano Jeremias, Mine Koruyucu, Erika C Küchler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genes expressed in dental enamel development are associated with molar-incisor hypomineralization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Oral Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archoralbio.2013.05.005"}], "href": "https://doi.org/10.1016/j.archoralbio.2013.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23790503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23790503"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Patir, F Seymen, M Yildirim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enamel formation genes are associated with high caries experience in Turkish children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Caries Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000154785"}], "href": "https://doi.org/10.1159/000154785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18781068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18781068"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "D Deutsch, Y Leiser, B Shay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Connect Tissue Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/03008200290001186"}], "href": "https://doi.org/10.1080/03008200290001186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12489194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12489194"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Z Mao, B Shay, M Hekmati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human tuftelin gene: cloning and characterization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0378-1119(01)00749-1"}], "href": "https://doi.org/10.1016/s0378-1119(01"}, {"type": "t", "text": "00749-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11733143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11733143"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "John R Shaffer, Jenna C Carlson, Brooklyn O C Stanley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of enamel matrix genes on dental caries are moderated by fluoride exposures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-014-1504-7"}], "href": "https://doi.org/10.1007/s00439-014-1504-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25373699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25373699"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Changwei Dou, Zhenyu Zhou, Qiuran Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "/PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0505-8"}], "href": "https://doi.org/10.1038/s41388-018-0505-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30250300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30250300"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bin Zhou, Hanxiang Zhan, Lamtin Tin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TUFT1 regulates metastasis of pancreatic cancer through HIF1-Snail pathway induced epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.08.017"}], "href": "https://doi.org/10.1016/j.canlet.2016.08.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27566398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27566398"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Guiyun Wu, Huatao Zhou, Danhua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DANCR upregulation induced by TUFT1 promotes malignant progression in triple negative breast cancer via miR-874-3p-SOX2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112331"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33058834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33058834"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hua Lin, Weifeng Zeng, Yuhang Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " PI3K/AKT Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/pore.2021.640936"}], "href": "https://doi.org/10.3389/pore.2021.640936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34257606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34257606"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jing Chen, Sheng Wu, Jue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0074269-mediated Upregulation of TUFT1 Through miR-485-5p Increases Cisplatin Resistance in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-022-00855-9"}], "href": "https://doi.org/10.1007/s43032-022-00855-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35075616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35075616"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tianning Wang, Lingyuan Min, Yan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation of TUFT1 is essential for gastric cancer progression through AKT/mTOR signaling pathway activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15618"}], "href": "https://doi.org/10.1111/cas.15618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36380570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36380570"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiong Du, Yanxin Li, Bin Lian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-128-3p inhibits proliferation and accelerates apoptosis of gastric cancer cells via inhibition of TUFT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-023-02906-0"}], "href": "https://doi.org/10.1186/s12957-023-02906-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36797791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36797791"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lei Zhu, Kai X Zhou, Ming Z Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/1590717"}], "href": "https://doi.org/10.1155/2022/1590717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35769513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35769513"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J L Yang, R F Fang, Q Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Gan Zang Bing Za Zhi (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn501113-20231107-00174"}], "href": "https://doi.org/10.3760/cma.j.cn501113-20231107-00174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38514264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38514264"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "M N Wu, J L Yang, S J Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of tuftelin protein and its clinical value in HBV-related liver cancer tissues]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Gan Zang Bing Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn501113-20200918-00519"}], "href": "https://doi.org/10.3760/cma.j.cn501113-20200918-00519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33979960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33979960"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lijun Zheng, Qiongzhen Ren, Weipei Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4319 targets tuftelin 1 to reduce malignancy of cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2024.70.3.8"}], "href": "https://doi.org/10.14715/cmb/2024.70.3.8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38650156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38650156"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Eeva Sliz, Mari Taipale, Maiju Welling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TUFT1, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0175474"}], "href": "https://doi.org/10.1371/journal.pone.0175474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28410428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28410428"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Annemieke J M H Verkerk, Daniela Andrei, Mathilde C S C Vermeer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of TUFT1, a Desmosome-Associated Protein, Causes Skin Fragility, Woolly Hair, and Palmoplantar Keratoderma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2023.02.044"}], "href": "https://doi.org/10.1016/j.jid.2023.02.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37716648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37716648"}]}]}]}
Proteins	TUFT1_HUMAN
NCBI Gene ID	7286
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TUFT1 has 10,321 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for TUFT1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TUFT1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TUFT1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUFT1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUFT1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TUFT1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TUFT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TUFT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUFT1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TUFT1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TUFT1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TUFT1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TUFT1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TUFT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TUFT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TUFT1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TUFT1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TUFT1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TUFT1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TUFT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TUFT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TUFT1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TUFT1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TUFT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TUFT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TUFT1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TUFT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TUFT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TUFT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TUFT1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TUFT1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TUFT1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TUFT1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TUFT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TUFT1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TUFT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TUFT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TUFT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TUFT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TUFT1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TUFT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TUFT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.