UBA2 Gene

HGNC Family	Ubiquitin-like activating enzymes (UBA)
Name	ubiquitin-like modifier activating enzyme 2
Description	Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBA2, the catalytic subunit of the SUMO‐activating (E1) enzyme complex (also known as SAE2), is fundamental to the SUMOylation cascade. Structural studies have delineated its interactions within the heterodimeric complex with SAE1 and revealed details of Mg.ATP–dependent adenylation and thioester bond formation, while functional analyses in Myc‐driven cancer models demonstrate that SAE2 activity is necessary for switching transcriptional programs and supporting proliferation, underscoring its pivotal role in modulating protein SUMOylation. Moreover, SAE2 undergoes autoSUMOylation, which can inhibit SUMO transfer to the E2–conjugating enzyme, and its nucleocytoplasmic shuttling is regulated by SUMO modification of residues adjacent to its nuclear localization sequence; additional studies have identified discrete import signals driving the nuclear localization of both isolated subunits and the assembled E1 complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic alterations in UBA2 have been implicated in developmental disorders. In patients with congenital scalp defects such as aplasia cutis congenita, de novo missense variants in UBA2 suggest that perturbation of SUMOylation can underlie craniofacial and extra‐cranial malformations. Similarly, pathogenic deletions and likely deleterious variants disrupting UBA2 have been identified in individuals with split‐hand/foot malformation and other limb anomalies, highlighting its importance in embryonic development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUBA2 has also emerged as a key regulator in oncogenesis. In colorectal cancer, its overexpression promotes cell cycle progression and invasive behavior, with knockdown studies leading to reduced proliferation and enhanced apoptosis. In acute myeloid leukemia, a fusion gene involving UBA2 and WTIP confers oncogenic properties by activating downstream signaling cascades such as STAT and ERK pathways. Similar oncogenic functions have been suggested in gastric cancer, non‐small cell lung cancer, and hepatocellular carcinoma – where aberrant UBA2 expression correlates with aggressive tumor behavior and poor prognosis – and potential roles are under investigation in glioma. Additionally, chemical genomics studies in cancer stem cells have identified compounds that directly target the SAE1/UBA2 complex to suppress SUMOylation and CSC function, suggesting therapeutic promise against cancers with hyperactive SUMO pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of host–pathogen interactions and inflammatory diseases, UBA2 function is similarly critical. During Shigella flexneri infection, calcium/calpain‐mediated cleavage of SAE2 (UBA2) leads to a marked reduction in global SUMOylation, a process that appears to facilitate bacterial invasion and modulate cytoskeletal dynamics. In rheumatoid arthritis, increased expression of SAE1/UBA2 in fibroblast‐like synoviocytes augments SUMOylation of key metabolic enzymes such as PKM2, promoting its phosphorylation, nuclear translocation, and reduced pyruvate kinase activity, which in turn drives glycolysis and enhances the aggressive, inflammatory phenotype of synoviocytes – positioning UBA2 as a potential therapeutic target in inflammatory joint disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luisa Maria Lois, Christopher D Lima "}, {"type": "b", "children": [{"type": "t", "text": "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600552"}], "href": "https://doi.org/10.1038/sj.emboj.7600552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15660128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15660128"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jessica D Kessler, Kristopher T Kahle, Tingting Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1212728"}], "href": "https://doi.org/10.1126/science.1212728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157079"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Khue Truong, Terry D Lee, Yuan Chen "}, {"type": "b", "children": [{"type": "t", "text": "Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.353789"}], "href": "https://doi.org/10.1074/jbc.M112.353789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22403398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22403398"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Khue Truong, Terry D Lee, Baozong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sumoylation of SAE2 C terminus regulates SAE nuclear localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.420877"}], "href": "https://doi.org/10.1074/jbc.M112.420877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23095757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23095757"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ping He, Xun Sun, Hong-Jing Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBA2 promotes proliferation of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9613"}], "href": "https://doi.org/10.3892/mmr.2018.9613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30387828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30387828"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michael Marble, Maria J Guillen Sacoto, Rashmi Chikarmane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Missense variant in UBA2 associated with aplasia cutis congenita, duane anomaly, hip dysplasia and other anomalies: A possible new disorder involving the SUMOylation pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38078"}], "href": "https://doi.org/10.1002/ajmg.a.38078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28110515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28110515"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kaori Yamoto, Hirotomo Saitsu, Gen Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive clinical and molecular studies in split-hand/foot malformation: identification of two plausible candidate genes (LRP6 and UBA2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-019-0473-7"}], "href": "https://doi.org/10.1038/s41431-019-0473-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332306"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jonas Elsner, Martin A Mensah, Manuel Holtgrewe, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-018-4573-5"}], "href": "https://doi.org/10.1186/s12864-018-4573-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29703139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29703139"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hongjing Cheng, Xun Sun, Ji Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Uba2 inhibits colorectal cancer cell invasion and migration through downregulation of the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26890"}], "href": "https://doi.org/10.1002/jcb.26890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29744931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29744931"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ji Li, Xun Sun, Ping He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v24.i42.4773"}], "href": "https://doi.org/10.3748/wjg.v24.i42.4773"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30479464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30479464"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Biying Jiang, Xiaoxi Fan, Di Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28543"}], "href": "https://doi.org/10.1002/jcb.28543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30848500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30848500"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yannick D Benoit, Ryan R Mitchell, Wenliang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Chem Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chembiol.2021.04.014"}], "href": "https://doi.org/10.1016/j.chembiol.2021.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33979648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33979648"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuhong Ou, Hongtao Luo, Qiuning Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "UBA2 SUMOylates NQO1 and promotes the proliferation of hepatocellular carcinoma by modulating the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.16290"}], "href": "https://doi.org/10.1111/cas.16290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39013843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39013843"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Pierre Lapaquette, Sabrina Fritah, Nouara Lhocine, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Shigella"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.27444"}], "href": "https://doi.org/10.7554/eLife.27444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29231810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29231810"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cuicui Wang, Youjun Xiao, Minxi Lao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.135935"}], "href": "https://doi.org/10.1172/jci.insight.135935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32938830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32938830"}]}]}]}
Synonyms	ARX, HRIHFB2115
Proteins	SAE2_HUMAN
NCBI Gene ID	10054
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBA2 has 7,663 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for UBA2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBA2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by UBA2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBA2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBA2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBA2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBA2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving UBA2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBA2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBA2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBA2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UBA2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBA2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBA2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBA2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBA2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBA2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with UBA2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UBA2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBA2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UBA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing UBA2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBA2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBA2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBA2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBA2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBA2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBA2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBA2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBA2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UBA2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.