| HGNC Family | Ubiquitin-conjugating enzymes E2 (UBE2) |
| Name | ubiquitin-conjugating enzyme E2C |
| Description | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2C is an essential E2 ubiquitin‐conjugating enzyme that partners with the anaphase‐promoting complex/cyclosome (APC/C) to mediate the ubiquitination and proteasomal degradation of key mitotic regulators—such as cyclin B—ensuring proper progression through mitosis. Mechanistic studies reveal that UBE2C’s activity is finely tuned by its inherent N‐terminal extension and specific E2–E3 interfaces, enabling precise substrate lysine selection and preventing premature centrosome duplication, lagging chromosomes, and aneuploidy. Its proper function is critical for maintaining genomic stability by regulating the spindle assembly checkpoint and controlling the temporal degradation of mitotic proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a wide range of human malignancies—including tumors of the thyroid, breast, colon, prostate, liver, endometrium, and others—UBE2C is frequently overexpressed, serving as a prominent proto‐oncogene associated with tumor progression, poor differentiation, and chemoresistance. Elevated UBE2C levels often arise through mechanisms such as chromosomal amplification and aberrant transcriptional regulation by factors including FoxM1, MED1, and estrogen receptor α. Functionally, its overexpression disrupts cell cycle control, promotes epithelial–mesenchymal transition and invasion, and enhances cell proliferation. Importantly, targeted downregulation of UBE2C (via siRNA or pharmacologic inhibition) markedly impairs tumor growth and increases sensitivity to conventional therapeutics, underscoring its potential as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoshiaki Okamoto, Toshinori Ozaki, Kou Miyazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12874022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12874022"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Klaus W Wagner, Lisa M Sapinoso, Wa'el El-Rifai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207861"}], "href": "https://doi.org/10.1038/sj.onc.1207861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15208666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15208666"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "P Pallante, M T Berlingieri, G Troncone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6602721"}], "href": "https://doi.org/10.1038/sj.bjc.6602721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16106252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16106252"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yasuo Takahashi, Yukimoto Ishii, Yayoi Nishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2005.12.011"}], "href": "https://doi.org/10.1016/j.cancergencyto.2005.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16772118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16772118"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Keisuke Ieta, Eiki Ojima, Fumiaki Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.22605"}], "href": "https://doi.org/10.1002/ijc.22605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17354233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17354233"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lei Jiang, Cheng-Guang Huang, Yi-Cheng Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2008.01.037"}], "href": "https://doi.org/10.1016/j.brainres.2008.01.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18331723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18331723"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Adam Walker, Claire Acquaviva, Takahiro Matsusaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.031591"}], "href": "https://doi.org/10.1242/jcs.031591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18559889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18559889"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "G Donato, G Iofrida, A Lavano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Neuropathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5414/npp27219"}], "href": "https://doi.org/10.5414/npp27219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18666437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18666437"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Matthew K Summers, Borlan Pan, Kiran Mukhyala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.07.014"}], "href": "https://doi.org/10.1016/j.molcel.2008.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18722180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18722180"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Takeo Fujita, Hirokuni Ikeda, Kensuke Kawasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological relevance of UbcH10 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2008.01026.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2008.01026.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19038004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19038004"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Takeo Fujita, Hirokuni Ikeda, Naruto Taira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-9-87"}], "href": "https://doi.org/10.1186/1471-2407-9-87"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19302711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19302711"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lei Jiang, Yi Bao, Chun Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-009-0651-z"}], "href": "https://doi.org/10.1007/s00432-009-0651-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19657671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19657671"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shimin Chen, Yingjian Chen, Chengjin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of clinicopathological features with UbcH10 expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-009-0672-7"}], "href": "https://doi.org/10.1007/s00432-009-0672-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19779934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19779934"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Minglian Zhao, Nan-Yan Zhang, Ashley Zurawel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.060095"}], "href": "https://doi.org/10.1074/jbc.M109.060095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20007692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20007692"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Janine H van Ree, Karthik B Jeganathan, Liviu Malureanu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200906147"}], "href": "https://doi.org/10.1083/jcb.200906147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20065091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20065091"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zhong Chen, Chunpeng Zhang, Dayong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.154"}], "href": "https://doi.org/10.1038/emboj.2011.154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21556051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21556051"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "A Psyrri, K T Kalogeras, R Kronenwett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/annonc/mdr527"}], "href": "https://doi.org/10.1093/annonc/mdr527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22056852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22056852"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Pierlorenzo Pallante, Umberto Malapelle, Maria Teresa Berlingieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2012.09.033"}], "href": "https://doi.org/10.1016/j.ejca.2012.09.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23102841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23102841"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Niels Fristrup, Karin Birkenkamp-Demtröder, Thomas Reinert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multicenter validation of cyclin D1, MCM7, TRIM29, and UBE2C as prognostic protein markers in non-muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2012.10.017"}], "href": "https://doi.org/10.1016/j.ajpath.2012.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23201130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23201130"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Toshima Z Parris, Anikó Kovács, Luaay Aziz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28497"}], "href": "https://doi.org/10.1002/ijc.28497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24114735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24114735"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Shang-Ze Li, Yang Song, Hui-Hui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep06910"}], "href": "https://doi.org/10.1038/srep06910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25376843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25376843"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yingyi Zhang, Ting Han, Guo Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of microRNA-17/20a suppresses cell proliferation in gastric cancer by modulating UBE2C expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3835"}], "href": "https://doi.org/10.3892/or.2015.3835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25760688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25760688"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Nicholas G Brown, Ryan VanderLinden, Edmond R Watson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1504161112"}], "href": "https://doi.org/10.1073/pnas.1504161112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25825779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25825779"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Qinglin Han, Chun Zhou, Fan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4049"}], "href": "https://doi.org/10.3892/or.2015.4049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26062455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26062455"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Thomas Wild, Marie Sofie Yoo Larsen, Takeo Narita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.01.060"}], "href": "https://doi.org/10.1016/j.celrep.2016.01.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26904940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26904940"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Won Tae Kim, Pildu Jeong, Chunri Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2C cell-free RNA in urine can discriminate between bladder cancer and hematuria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11277"}], "href": "https://doi.org/10.18632/oncotarget.11277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27528424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27528424"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Rui Wang, Yue Song, Xi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2C induces EMT through Wnt/β‑catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.3880"}], "href": "https://doi.org/10.3892/ijo.2017.3880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28260026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28260026"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Liang Guo, Zhiming Ding, Nunu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1356507"}], "href": "https://doi.org/10.1080/15384101.2017.1356507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28767320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28767320"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Tao Qin, Gena Huang, Liyuan Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exceptionally high UBE2C expression is a unique phenomenon in basal-like type breast cancer and is regulated by BRCA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.08.095"}], "href": "https://doi.org/10.1016/j.biopha.2017.08.095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28881292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28881292"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yan Zhang, Suli Tian, Xiaodong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2C promotes rectal carcinoma via miR-381."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2017.1416939"}], "href": "https://doi.org/10.1080/15384047.2017.1416939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29303411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29303411"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yan Liu, Rong Zhao, Shuqi Chi, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "UBE2C"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-0561"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-0561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31662448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31662448"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Jiajia Li, Xiuling Zhi, Xiaoqing Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.12.058"}], "href": "https://doi.org/10.1016/j.bbrc.2019.12.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31875843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31875843"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "An-Jen Chiang, Chia-Jung Li, Kuan-Hao Tsui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom11010037"}], "href": "https://doi.org/10.3390/biom11010037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33396624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33396624"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Zi-Nan Lu, Jia Song, Tong-Hui Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2C affects breast cancer proliferation through the AKT/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med J (Engl) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CM9.0000000000001708"}], "href": "https://doi.org/10.1097/CM9.0000000000001708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34620747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34620747"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Shizhen Zhang, Xiahong You, Yawen Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI162434"}], "href": "https://doi.org/10.1172/JCI162434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36548081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36548081"}]}]}]}
|
| Synonyms | DJ447F3.2, UBCH10 |
| Proteins | UBE2C_HUMAN |
| NCBI Gene ID | 11065 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
UBE2C has 13,904 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.
Click the + buttons to view associations for UBE2C from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of UBE2C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of UBE2C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of UBE2C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UBE2C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UBE2C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of UBE2C gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of UBE2C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with UBE2C protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with UBE2C gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2C gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of UBE2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of UBE2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of UBE2C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing UBE2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing UBE2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing UBE2C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing UBE2C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with UBE2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with UBE2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of UBE2C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with UBE2C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with UBE2C gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of UBE2C protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with UBE2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with UBE2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with UBE2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with UBE2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UBE2C gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2C gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of UBE2C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing UBE2C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with UBE2C gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with UBE2C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing UBE2C from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of UBE2C gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving UBE2C gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving UBE2C gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving UBE2C gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing UBE2C protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing UBE2C protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing UBE2C protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by UBE2C gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by UBE2C gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by UBE2C gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of UBE2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of UBE2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with UBE2C gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for UBE2C protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of UBE2C gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of UBE2C protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with UBE2C gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with UBE2C gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by UBE2C gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for UBE2C protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of UBE2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of UBE2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of UBE2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving UBE2C protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving UBE2C protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of UBE2C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of UBE2C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with UBE2C gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of UBE2C gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of UBE2C gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of UBE2C gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of UBE2C gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing UBE2C protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain UBE2C protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by UBE2C gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting UBE2C gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of UBE2C gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for UBE2C from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of UBE2C gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of UBE2C gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing UBE2C protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PANTHER Pathways | pathways involving UBE2C protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for UBE2C from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of UBE2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of UBE2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving UBE2C protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving UBE2C protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving UBE2C protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving UBE2C protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of UBE2C gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UBE2C gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UBE2C gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of UBE2C gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of UBE2C gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with UBE2C protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of UBE2C gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of UBE2C gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of UBE2C gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of UBE2C gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of UBE2C gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of UBE2C protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of UBE2C protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of UBE2C protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with UBE2C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with UBE2C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving UBE2C protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving UBE2C protein from the WikiPathways Pathways 2024 dataset. | |