UBE2M Gene

HGNC Family	Ubiquitin-conjugating enzymes E2 (UBE2)
Name	ubiquitin-conjugating enzyme E2M
Description	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2M (also known as Ubc12) is the dedicated NEDD8‐conjugating enzyme essential to the neddylation cascade that activates Cullin–RING E3 ligases (CRLs). Structural and mutational studies reveal that UBE2M accepts activated NEDD8 from its heterodimeric E1 and is recruited in a manner that mimics ubiquitin binding, while its N‐terminal acetylation is specifically recognized by DCN-like co-E3 proteins. In addition, auxiliary factors such as glycyl-tRNA synthetase protect the NEDD8-charged UBE2M from premature degradation, and its auto-neddylation is tightly regulated by deNEDDylases like SENP8 to ensure proper substrate turnover and CRL function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUnder stress and in pathological contexts, UBE2M expression is often upregulated and plays multifaceted roles in cellular homeostasis. In tumor cells, UBE2M not only drives neddylation-dependent degradation of key cell cycle inhibitors (for example, promoting p27 clearance in response to chemotherapeutic agents like gemcitabine) but also exhibits dual functionality by mediating ubiquitination events that target other E2 enzymes (such as UBE2F), thereby reprogramming CRL activity. These activities impinge on genomic stability, as impaired UBE2M function leads to accumulation of CRL substrates, defective DNA damage responses, and aberrant activation of signaling pathways including β-catenin/cyclin D1, SREBP-1 stabilization, and even Wnt/β-catenin via Axin degradation. Moreover, genetic variants affecting UBE2M and its protein interactions have been linked to altered responses in cancers such as metastatic colorectal cancer, hepatocellular carcinoma, and osteoarthritis-associated chondrocyte degeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe central role of UBE2M in regulating neddylation has spurred preclinical efforts to modulate its activity for therapeutic benefit. Inhibition of the neddylation pathway using agents such as MLN4924—which targets the NEDD8-activating enzyme—has proven effective in reducing tumor cell viability in intrahepatic cholangiocarcinoma and other malignancies, while selective blockade of the DCN1–UBE2M protein–protein interaction (with compounds like DI-591) can specifically inactivate subsets of CRLs (for example, those centered on Cullin 3). These targeted approaches, along with the identification of germline polymorphisms in UBE2M implicated in drug response, underscore the enzyme’s potential as both a prognostic marker and a therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, in hormone-dependent and metabolic disease contexts, UBE2M has been shown to participate in oncogenic feedback loops. In estrogen receptor–positive breast cancer, UBE2M maintains ERα expression by limiting its ubiquitination and degradation, while in metabolism-driven malignancies, factors such as NNMT-derived metabolites can upregulate UBE2M expression to reinforce neddylation-mediated degradation of cell cycle inhibitors, collectively promoting tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Danny T Huang, Amir Paydar, Min Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2004.12.020"}], "href": "https://doi.org/10.1016/j.molcel.2004.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15694336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15694336"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander Y Kim, Claire C Bommeljé, Benjamin E Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804440200"}], "href": "https://doi.org/10.1074/jbc.M804440200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18826954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18826954"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Julie K Monda, Daniel C Scott, Darcie J Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2012.10.013"}], "href": "https://doi.org/10.1016/j.str.2012.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23201271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23201271"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhongying Mo, Qian Zhang, Ze Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neddylation requires glycyl-tRNA synthetase to protect activated E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3250"}], "href": "https://doi.org/10.1038/nsmb.3250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27348078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27348078"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kate E Coleman, Miklós Békés, Jessica R Chapman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.24325"}], "href": "https://doi.org/10.7554/eLife.24325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475037"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "A-Mei Huang, Yu-Ting Kao, Shinzao Toh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2011.03.026"}], "href": "https://doi.org/10.1016/j.bcp.2011.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21477582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21477582"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Scott Cukras, Nicholas Morffy, Takbum Ohn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0101844"}], "href": "https://doi.org/10.1371/journal.pone.0101844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25025768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25025768"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sebastian Stintzing, Wu Zhang, Volker Heinemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-15-0121"}], "href": "https://doi.org/10.1158/1535-7163.MCT-15-0121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26206335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26206335"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Junhong Guan, Shuyu Yu, Xiaofeng Zheng "}, {"type": "b", "children": [{"type": "t", "text": "NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-017-0455-x"}], "href": "https://doi.org/10.1007/s13238-017-0455-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28831681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28831681"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guang-Cong Zhang, Xiang-Nan Yu, Jia-Lei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102749"}], "href": "https://doi.org/10.18632/aging.102749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32012120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32012120"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mi Jeong Heo, Sung Hyun Kang, Yun Seok Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.33113"}], "href": "https://doi.org/10.1002/ijc.33113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32449166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32449166"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Chun Ba, Xiaohui Ni, Junlong Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin conjugating enzyme E2 M promotes apoptosis in osteoarthritis chondrocytes via Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.095"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32819607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32819607"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiongzhi Lin, Dongsheng Sun, Shuhan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2M forms a positive feedback loop with estrogen receptor to drive breast cancer progression and drug resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-06979-x"}], "href": "https://doi.org/10.1038/s41419-024-06979-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39138151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39138151"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Qiang Gao, Guang-Yang Yu, Jie-Yi Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2309"}], "href": "https://doi.org/10.18632/oncotarget.2309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25229838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25229838"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Haibin Zhou, Jianfeng Lu, Liu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01243-7"}], "href": "https://doi.org/10.1038/s41467-017-01243-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29074978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29074978"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lihui Li, Jihui Kang, Wenjuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.06.005"}], "href": "https://doi.org/10.1016/j.ebiom.2019.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31208947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31208947"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Bin Zhao, Caiyan Gao, Daixiu Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7327"}], "href": "https://doi.org/10.3892/or.2019.7327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31545502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31545502"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yilei Ma, Xucheng Huang, Yanzhong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202305907"}], "href": "https://doi.org/10.1002/advs.202305907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38126621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38126621"}]}]}]}
Synonyms	HUBC12, UBC12, UBC-RS2
Proteins	UBC12_HUMAN
NCBI Gene ID	9040
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE2M has 7,403 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for UBE2M from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE2M Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2M gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2M gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE2M gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE2M gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE2M gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2M gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving UBE2M protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2M gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2M gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2M gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2M gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2M gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE2M protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2M gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE2M gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE2M gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UBE2M protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE2M gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE2M protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UBE2M protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBE2M protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE2M protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2M gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE2M gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE2M gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE2M gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UBE2M protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UBE2M gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE2M gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE2M gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE2M gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE2M gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE2M gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2M gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE2M gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE2M from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2M gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBE2M gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing UBE2M from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of UBE2M gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.