UBE2Q2 Gene

HGNC Family	Ubiquitin-conjugating enzymes E2 (UBE2)
Name	ubiquitin-conjugating enzyme E2Q family member 2
Description	Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2Q2 is a member of the ubiquitin‐conjugating enzyme (E2) family, a group of proteins that facilitate the attachment of ubiquitin to specific cellular substrates for degradation and regulation of signaling pathways. A genome‐wide association study in chronic kidney disease identified UBE2Q2 as one of several loci associated with renal function, suggesting a potential link between its genetic variation and kidney biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In several carcinomas, altered expression of UBE2Q2 has been observed. Studies in breast cancer have shown that UBE2Q2 mRNA and protein levels are elevated in tumor tissues relative to adjacent normal tissues, particularly within invasive epithelial compartments. Similar findings have been reported in head and neck squamous cell carcinoma and acute lymphoblastic leukemia, and a related gene product carrying an E2 domain (LOC92912) has been noted to interact with actin and associated cytoskeletal proteins, hinting at a role in regulating cellular dynamics and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "Functional investigations have further elucidated the role of UBE2Q2 in cell cycle regulation and response to therapeutic agents. Notably, UBE2Q2 is capable of covalently binding ubiquitin via its active-site cysteine, and its inhibition leads to an early mitotic (prophase) arrest as well as enhanced sensitivity to microtubule inhibitors through caspase-mediated apoptosis, suggesting that under normal conditions, it participates in overcoming early mitotic checkpoints. Additionally, differential expression patterns in drug-resistant head and neck cancer cell lines, along with emerging studies on its promoter methylation status, support a multifaceted role where UBE2Q2 may function as both a facilitator of cell cycle progression and, under certain contexts, act as an oncosuppressor influencing tumor growth and chemotherapeutic response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anna Köttgen, Cristian Pattaro, Carsten A Böger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New loci associated with kidney function and chronic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.568"}], "href": "https://doi.org/10.1038/ng.568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20383146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20383146"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mohsen Nikseresht, Atefeh Seghatoleslam, Ahmad Monabati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the novel human gene, UBE2Q2, in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2009.11.020"}], "href": "https://doi.org/10.1016/j.cancergencyto.2009.11.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20193842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20193842"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Atefeh Seghatoleslam, Ahmad Monabati, Farzaneh Bozorg-Ghalati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Iran Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "012156/AIM.007"}], "href": "https://doi.org/012156/AIM.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22642244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22642244"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Atefeh Seghatoleslam, Alberto Zambrano, Regine Millon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.11.026"}], "href": "https://doi.org/10.1016/j.bbrc.2005.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16300736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16300736"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S Banerjee, W S Brooks, D F Crawford "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210471"}], "href": "https://doi.org/10.1038/sj.onc.1210471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17471241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17471241"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hiroyuki Maeda, Naoto Miyajima, Satoshi Kano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-08-0543"}], "href": "https://doi.org/10.1158/1541-7786.MCR-08-0543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19723876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19723876"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pooneh Mokarram, Fatemeh Shakiba-Jam, Soudabeh Kavousipour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2015.16.18.8247"}], "href": "https://doi.org/10.7314/apjcp.2015.16.18.8247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26745068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26745068"}]}]}]}
Proteins	UB2Q2_HUMAN
NCBI Gene ID	92912
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE2Q2 has 5,022 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for UBE2Q2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE2Q2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Q2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Q2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE2Q2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE2Q2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE2Q2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Q2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2Q2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2Q2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2Q2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2Q2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBE2Q2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2Q2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE2Q2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE2Q2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of UBE2Q2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE2Q2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UBE2Q2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBE2Q2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE2Q2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE2Q2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE2Q2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE2Q2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with UBE2Q2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UBE2Q2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE2Q2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with UBE2Q2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UBE2Q2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE2Q2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE2Q2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE2Q2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE2Q2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE2Q2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2Q2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE2Q2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE2Q2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with UBE2Q2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBE2Q2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing UBE2Q2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of UBE2Q2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of UBE2Q2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.