UIMC1 Gene

Name	ubiquitin interaction motif containing 1
Description	This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUIMC1, also known as RAP80, is a nuclear adaptor protein endowed with tandem ubiquitin‐interacting motifs (UIMs) and a SUMO‐interacting motif (SIM) that enable it to bind with high affinity to K63‐linked polyubiquitin chains as well as SUMO‐modified substrates at sites of DNA double–strand breaks. Through these interactions, UIMC1 recruits the tumor suppressor BRCA1 together with its associated partners (such as Abraxas and BRCC36) to DNA damage foci, thereby ensuring proper checkpoint control and mediating homologous recombination repair. Its ability to recognize hybrid ubiquitin–SUMO signals—in part facilitated by upstream regulators like RNF8—underscores its vital role in orchestrating the DNA damage response and maintaining genomic integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies have revealed that UIMC1 functions as a fine–tuner of BRCA1 activity by restraining excessive DNA end resection, thus modulating homologous recombination to prevent chromosomal instability. Through its assembly into the BRCA1–A complex—and interactions with other factors such as MERIT40—UIMC1 stabilizes the complex’s formation at damaged chromatin and supports effective cell cycle checkpoint control. Disruption of UIMC1–mediated recruitment has been linked to impaired DNA repair and heightened sensitivity to genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, genomic analyses have linked the chromosomal region encompassing UIMC1 to traits such as the timing of menarche and menopause, suggesting broader biological roles beyond DNA repair. Structural insights into RAP80 emphasize elements like zinc finger motifs and the bipartite nuclear localization signal—which are critical for its integration into transcription–regulatory networks—thereby further highlighting UIMC1’s multifaceted contribution to cellular homeostasis and tumor suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Wang, Shuhei Matsuoka, Bryan A Ballif, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1139476"}], "href": "https://doi.org/10.1126/science.1139476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525340"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bijan Sobhian, Genze Shao, Dana R Lilli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1139516"}], "href": "https://doi.org/10.1126/science.1139516"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525341"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongtae Kim, Junjie Chen, Xiaochun Yu "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1139621"}], "href": "https://doi.org/10.1126/science.1139621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17525342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17525342"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bin Wang, Stephen J Elledge "}, {"type": "b", "children": [{"type": "t", "text": "Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0710061104"}], "href": "https://doi.org/10.1073/pnas.0710061104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18077395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18077395"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yiduo Hu, Ralph Scully, Bijan Sobhian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2011011"}], "href": "https://doi.org/10.1101/gad.2011011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21406551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21406551"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jun Yan, Yong-Sik Kim, Xiao-Ping Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-0924"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-0924"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17621610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17621610"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Catherine M Guzzo, Christopher E Berndsen, Jianmei Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2003485"}], "href": "https://doi.org/10.1126/scisignal.2003485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23211528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23211528"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Joshua J Sims, Robert E Cohen "}, {"type": "b", "children": [{"type": "t", "text": "Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.02.011"}], "href": "https://doi.org/10.1016/j.molcel.2009.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19328070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19328070"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Genze Shao, Jeffrey Patterson-Fortin, Troy E Messick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1739609"}], "href": "https://doi.org/10.1101/gad.1739609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19261746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19261746"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xin Hu, Atanu Paul, Bin Wang "}, {"type": "b", "children": [{"type": "t", "text": "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.374116"}], "href": "https://doi.org/10.1074/jbc.M112.374116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22689573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22689573"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nam Soo Lee, Hee Jin Chung, Hyoung-June Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10463"}], "href": "https://doi.org/10.1038/ncomms10463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26781088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26781088"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "J Nikkilä, K A Coleman, D Morrissey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.33"}], "href": "https://doi.org/10.1038/onc.2009.33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19305427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19305427"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chunyan He, Peter Kraft, Constance Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association studies identify loci associated with age at menarche and age at natural menopause."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.385"}], "href": "https://doi.org/10.1038/ng.385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19448621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19448621"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhijiang Yan, Yong-Sik Kim, Anton M Jetten "}, {"type": "b", "children": [{"type": "t", "text": "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203475200"}], "href": "https://doi.org/10.1074/jbc.M203475200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12080054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12080054"}]}]}]}
Synonyms	RAP80, X2HRIP110
Proteins	UIMC1_HUMAN
NCBI Gene ID	51720
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UIMC1 has 6,979 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for UIMC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UIMC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by UIMC1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UIMC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UIMC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UIMC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UIMC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UIMC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UIMC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UIMC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UIMC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UIMC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UIMC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UIMC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UIMC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UIMC1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UIMC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UIMC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UIMC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UIMC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of UIMC1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UIMC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UIMC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UIMC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UIMC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UIMC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing UIMC1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UIMC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UIMC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with UIMC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with UIMC1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UIMC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UIMC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UIMC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UIMC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UIMC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UIMC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UIMC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UIMC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UIMC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UIMC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UIMC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.