| Name | ubiquinol-cytochrome c reductase complex assembly factor 4 |
| Description | Predicted to be involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not describe UQCC4; rather, it focuses on the novel rhomboid-like protein RHBDD2 and its roles in retinal development and function. RHBDD2 is shown to be expressed throughout retinal development, with its intracellular localization concentrated in the Golgi and the outer segments of cone photoreceptors. The study details how structural motifs, such as a glycine zipper within a transmembrane domain, facilitate proper packing into Golgi membranes, whereas disruption of this motif leads to protein dislocation. In addition, the authors identified a mutation (R85H) in RHBDD2 that co-segregates with autosomal recessive retinitis pigmentosa in a human pedigree, thereby underscoring its importance for retinal integrity.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBecause the abstract does not mention UQCC4, no direct functional insights on UQCC4 can be extracted from the provided study. While UQCC4 is known in broader literature as a protein involved in the assembly or regulation of mitochondrial respiratory complexes, any discussion regarding its function or cellular role is absent from this particular report."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Novruz B Ahmedli, Yekaterina Gribanova, Collins C Njoku, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.419960"}], "href": "https://doi.org/10.1074/jbc.M112.419960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23386608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23386608"}]}]}]}
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| NCBI Gene ID | 283951 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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UQCC4 has 455 functional associations with biological entities spanning 4 categories (chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.
Click the + buttons to view associations for UQCC4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UQCC4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of UQCC4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding UQCC4 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving UQCC4 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing UQCC4 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of UQCC4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of UQCC4 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of UQCC4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of UQCC4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of UQCC4 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of UQCC4 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of UQCC4 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of UQCC4 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of UQCC4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of UQCC4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
