{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study delineates how human mitochondrial ribosomes coordinate with membrane‐associated factors to facilitate the co‐translational insertion and early assembly of oxidative phosphorylation (OXPHOS) components. Although the abstract primarily focuses on the roles of factors such as TMEM223 in complex IV biogenesis and the SMIM4–C12ORF73 duo with UQCC1 and UQCC2 in initiating complex III assembly through interactions with cytochrome b, it does not explicitly report on UQCC5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nGiven the context, UQCC5—by virtue of its nomenclature and grouping with other UQCC proteins (UQCC1 and UQCC2), which are shown to be essential for early complex III biogenesis—can be inferred to play a role in the maturation or assembly of complex III. This inference stems from the emerging picture wherein multiple ribosome‐associated biogenesis factors couple mitochondrial translation to the assembly of respiratory chain complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In summary, while UQCC5 is not directly discussed in the provided abstract, its association within the UQCC family suggests it may function in the early steps of complex III assembly by aiding the integration and stabilization of newly synthesized cytochrome b, similar to UQCC1 and UQCC2. Further investigations will be needed to define its precise mechanistic role in the assembly process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sven Dennerlein, Sabine Poerschke, Silke Oeljeklaus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.68213"}], "href": "https://doi.org/10.7554/eLife.68213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34969438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34969438"}]}]}]}