{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUSP1 is a critical deubiquitinating enzyme that safeguards genome integrity by precisely regulating DNA damage responses and DNA replication. In its canonical role, USP1—most often in complex with its cofactor UAF1—removes ubiquitin from key substrates such as FANCD2 and FANCI, thereby modulating the Fanconi anemia pathway for interstrand crosslink repair. USP1 also controls postreplicative repair by deubiquitinating PCNA and fine‐tuning the activation and degradation of checkpoint effectors such as CHK1. Moreover, USP1’s activity supports replication fork stability and governs the processing of replication‐associated single‐stranded DNA gaps, ensuring appropriate recovery from replication stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUSP1 also exerts multifaceted functions in oncogenic signaling and therapeutic resistance across a spectrum of human cancers. By deubiquitinating and stabilizing a diverse set of proteins—including members of the ID family, Snail, KPNA2, EZH2, and TAZ—USP1 fosters the maintenance of stem cell–like phenotypes, promotes epithelial‐to‐mesenchymal transition and metastasis, and underpins resistance to chemotherapy. Dysregulated expression of USP1 has been documented in malignancies such as osteosarcoma, glioblastoma, ovarian and breast cancers, multiple myeloma, chronic myeloid leukemia, acute lymphoblastic leukemia, and hepatocellular carcinoma. In these contexts, USP1’s modulation of signaling pathways like PI3K/AKT and TGF‑β—as well as its control over factors involved in cell cycle regulation and apoptosis—renders it an attractive therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in DNA repair and oncogenic signaling, USP1 influences other fundamental cellular processes such as viral replication and autophagy. For example, during human papillomavirus infection, USP1 (along with related deubiquitinases) associates with viral helicase proteins to facilitate efficient replication of the viral genome. USP1 also regulates autophagy by deubiquitinating ULK1, thereby modulating the balance between canonical and non‐canonical autophagic pathways and influencing cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sebastian M B Nijman, Tony T Huang, Annette M G Dirac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.01.008"}], "href": "https://doi.org/10.1016/j.molcel.2005.01.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15694335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15694335"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "E Barroso, G Pita, J I Arias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-009-0439-5"}], "href": "https://doi.org/10.1007/s10549-009-0439-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19536649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19536649"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jean-Hugues Guervilly, Emilie Renaud, Minoru Takata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr103"}], "href": "https://doi.org/10.1093/hmg/ddr103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21389083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21389083"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jennifer T Fox, Kyoo-young Lee, Kyungjae Myung "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic regulation of PCNA ubiquitylation/deubiquitylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.05.053"}], "href": "https://doi.org/10.1016/j.febslet.2011.05.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640107"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiomaris M Cotto-Rios, Mathew J K Jones, Luca Busino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201101062"}], "href": "https://doi.org/10.1083/jcb.201101062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21768287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21768287"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "A P Bertolin, S F Mansilla, V Gottifredi "}, {"type": "b", "children": [{"type": "t", "text": "The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2015.04.027"}], "href": "https://doi.org/10.1016/j.dnarep.2015.04.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26002196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26002196"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Atsuko Niimi, Suzanna R Hopkins, Jessica A Downs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BAH domain of BAF180 is required for PCNA ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrfmmm.2015.06.006"}], "href": "https://doi.org/10.1016/j.mrfmmm.2015.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26117423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26117423"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anne Olazabal-Herrero, Iraia García-Santisteban, Jose Antonio Rodríguez "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.13648"}], "href": "https://doi.org/10.1111/febs.13648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26758085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26758085"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kah Suan Lim, Heng Li, Emma A Roberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2018.10.045"}], "href": "https://doi.org/10.1016/j.molcel.2018.10.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30576655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30576655"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Martin L Rennie, Connor Arkinson, Viduth K Chaugule, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of FANCD2 deubiquitination by USP1-UAF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-021-00576-8"}], "href": "https://doi.org/10.1038/s41594-021-00576-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33795880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33795880"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexandra Nusawardhana, Lindsey M Pale, Claudia M Nicolae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkad1237"}], "href": "https://doi.org/10.1093/nar/gkad1237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38180818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38180818"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Samuel A Williams, Heather L Maecker, Dorothy M French, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.07.040"}], "href": "https://doi.org/10.1016/j.cell.2011.07.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21925315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21925315"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Iraia Garcia-Santisteban, Kerman Zorroza, Jose Antonio Rodriguez "}, {"type": "b", "children": [{"type": "t", "text": "Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0038570"}], "href": "https://doi.org/10.1371/journal.pone.0038570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22701671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22701671"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anne Olazabal-Herrero, Iraia García-Santisteban, Jose Antonio Rodríguez "}, {"type": "b", "children": [{"type": "t", "text": "Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-015-0311-7"}], "href": "https://doi.org/10.1186/s12943-015-0311-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25744535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25744535"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gilbert J Rahme, Zhonghua Zhang, Alison L Young, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2157"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26951930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26951930"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Scott Cukras, Euiho Lee, Emily Palumbo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2016.1209613"}], "href": "https://doi.org/10.1080/15384101.2016.1209613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27463890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27463890"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jinbo Liu, Hongjun Zhu, Ning Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3752"}], "href": "https://doi.org/10.3892/ijo.2016.3752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27840911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27840911"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jussara Maria Goncalves, Mabel Mariela Rodriguez Cordeiro, Elena Riet Correa Rivero "}, {"type": "b", "children": [{"type": "t", "text": "The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Stem Cell Res Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1574888X12666170315104013"}], "href": "https://doi.org/10.2174/1574888X12666170315104013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28302046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28302046"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Li Ma, Kangyu Lin, Guoqiang Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant Activation of β-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-18-1304"}], "href": "https://doi.org/10.1158/0008-5472.CAN-18-1304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30425057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30425057"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "S V Antonenko, D S Gurianov, G D Тelegeev "}, {"type": "b", "children": [{"type": "t", "text": "Colocalization of USP1 and РН domain of Bcr­Abl oncoprotein in terms of cronic myeloid leukemia cell rearrangements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tsitol Genet (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30480413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30480413"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Aihui Ma, Ming Tang, Li Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0590-8"}], "href": "https://doi.org/10.1038/s41388-018-0590-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30531833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30531833"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Maura Sonego, Ilenia Pellarin, Alice Costa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aav3235"}], "href": "https://doi.org/10.1126/sciadv.aav3235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31086816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31086816"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yalei Zhao, Chen Xue, Zhongyang Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12908"}], "href": "https://doi.org/10.1111/cpr.12908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32951278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32951278"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xingyi Kuang, Jie Xiong, Tingting Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.47597"}], "href": "https://doi.org/10.7150/ijms.47597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33390793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33390793"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Dianwen Han, Lijuan Wang, Bing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1874695"}], "href": "https://doi.org/10.1080/15384101.2021.1874695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33461373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33461373"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Nuoya Li, Lei Wu, Xingye Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 Promotes GC Metastasis via Stabilizing ID2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/3771990"}], "href": "https://doi.org/10.1155/2021/3771990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34873426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34873426"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Putao Yuan, Zhenhua Feng, Hai Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 inhibition suppresses the progression of osteosarcoma via destabilizing TAZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.65428"}], "href": "https://doi.org/10.7150/ijbs.65428"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35637948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35637948"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xiaotong Zhu, Peng Wang, Xiaoxia Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Immunol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41423-022-00969-9"}], "href": "https://doi.org/10.1038/s41423-022-00969-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36600049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36600049"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Shuguang Liu, Yuening Xiang, Boshi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2022008284"}], "href": "https://doi.org/10.1182/bloodadvances.2022008284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36912760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36912760"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Dongyi Liu, Quanhui Li, Yifeng Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05777-1"}], "href": "https://doi.org/10.1038/s41419-023-05777-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37041150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37041150"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Michaël Lehoux, David Gagnon, Jacques Archambault "}, {"type": "b", "children": [{"type": "t", "text": "E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00379-14"}], "href": "https://doi.org/10.1128/JVI.00379-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24850727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24850727"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Marzia Raimondi, Daniela Cesselli, Carla Di Loreto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2018.1535291"}], "href": "https://doi.org/10.1080/15548627.2018.1535291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30335599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30335599"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Marit Orav, David Gagnon, Jacques Archambault "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.00152-19"}], "href": "https://doi.org/10.1128/mBio.00152-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30890612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30890612"}]}]}]}