USP17L19 Gene

Name ubiquitin specific peptidase 17-like family member 19
Description Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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Consequently, no functional information relating to USP17L19 is provided in this set of publications, and there is no evidence from these abstracts linking USP17L19 to the immune, inflammatory, or tissue remodeling processes described."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paula Marie Hughes, Michelle Sandra Botham, Stefan Frentzel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11870871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11870871"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Philippe Lesnik, Christopher A Haskell, Israel F Charo "}, {"type": "b", "children": [{"type": "t", "text": "Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15555"}], "href": "https://doi.org/10.1172/JCI15555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12569158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12569158"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "G Tarozzo, S Bortolazzi, C Crochemore, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Behav Immun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbi.2016.01.001"}], "href": "https://doi.org/10.1016/j.bbi.2016.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26765996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26765996"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Matthew K Zabel, Lian Zhao, Yikui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.23016"}], "href": "https://doi.org/10.1002/glia.23016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27314452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27314452"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Valérie Amsellem, Shariq Abid, Lucie Poupel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2016-0201OC"}], "href": "https://doi.org/10.1165/rcmb.2016-0201OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28125278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28125278"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Anastassia Voronova, Scott A Yuzwa, Beatrix S Wang, et al. 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Proteins U17LJ_HUMAN
NCBI Gene ID 100287404
API
Download Associations
Predicted Functions View USP17L19's ARCHS4 Predicted Functions.
Co-expressed Genes View USP17L19's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View USP17L19's ARCHS4 Predicted Functions.

Functional Associations

USP17L19 has 323 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for USP17L19 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of USP17L19 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L19 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of USP17L19 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with USP17L19 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L19 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
GO Biological Process Annotations 2015 biological processes involving USP17L19 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving USP17L19 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving USP17L19 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing USP17L19 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing USP17L19 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing USP17L19 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by USP17L19 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by USP17L19 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by USP17L19 gene from the curated GO Molecular Function Annotations 2025 dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of USP17L19 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for USP17L19 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of USP17L19 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L19 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Reactome Pathways 2024 pathways involving USP17L19 protein from the Reactome Pathways 2024 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of USP17L19 gene from the Rummagene Transcription Factor Associations 2026 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with USP17L19 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.