USP17L21 Gene

Name ubiquitin specific peptidase 17-like family member 21
Description Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract from PubMed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "focuses on the role of KDM6A in regulating reproduction‐related homeobox genes (Rhox6 and Rhox9) via histone H3 lysine 27 demethylation in a sexually dimorphic manner. Notably, there is no mention or discussion of USP17L21 in the abstract. Consequently, based on this provided abstract, no functional information regarding USP17L21 is available.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joel B Berletch, Xinxian Deng, Di Kim Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1003489"}], "href": "https://doi.org/10.1371/journal.pgen.1003489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23658530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23658530"}]}]}]}
Proteins U17LL_HUMAN
NCBI Gene ID 100287478
API
Download Associations
Predicted Functions View USP17L21's ARCHS4 Predicted Functions.
Co-expressed Genes View USP17L21's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View USP17L21's ARCHS4 Predicted Functions.

Functional Associations

USP17L21 has 368 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for USP17L21 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of USP17L21 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L21 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with USP17L21 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with USP17L21 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2015 biological processes involving USP17L21 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving USP17L21 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving USP17L21 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing USP17L21 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing USP17L21 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing USP17L21 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by USP17L21 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by USP17L21 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by USP17L21 gene from the curated GO Molecular Function Annotations 2025 dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of USP17L21 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for USP17L21 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of USP17L21 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L21 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Reactome Pathways 2024 pathways involving USP17L21 protein from the Reactome Pathways 2024 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of USP17L21 gene from the Rummagene Transcription Factor Associations 2026 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of USP17L21 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with USP17L21 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.