| Name | ubiquitin specific peptidase 17-like family member 26 |
| Description | Enables RNA binding activity; cysteine-type deubiquitinase activity; and hyaluronic acid binding activity. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUSP17L26, a member of the ubiquitin‐specific protease family, is hypothesized to act as a critical regulator of intracellular signaling by controlling the ubiquitination status—and hence the stability and activity—of key signaling proteins. Although none of the provided abstracts mention USP17L26 explicitly, many describe processes in which precise post‐translational regulation is essential. For example, in pancreatic β cells, fine‐tuning of p38 MAPK signaling governs insulin secretion and cellular survival, while TGF‑β–mediated pathways require stringent control to prevent fibrotic and inflammatory responses. Such regulatory dynamics parallel those attributed to deubiquitinating enzymes, suggesting that USP17L26 may similarly modulate protein turnover in these pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond controlling kinase cascades, USP17L26 may also influence the immune microenvironment by modulating chemokine signals. Several abstracts underscore the role of the CCL22–CCR4 axis in recruiting regulatory T cells and shaping both innate and adaptive immune responses in contexts ranging from autoimmune diabetes to inflammatory bone resorption and tumor immunosuppression. By deubiquitinating signaling intermediates that regulate chemokine production or receptor turnover, USP17L26 could fine‑tune the balance between pro‑ and anti‑inflammatory cues—thereby indirectly affecting immune cell trafficking and function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, USP17L26 may have broader implications in the regulation of cellular differentiation, metabolic reprogramming, and proliferative control. The described studies reveal complex networks wherein p38 MAPK isoforms, mTOR signaling, and other stress‐responsive pathways orchestrate processes such as cardiac growth, skeletal muscle regeneration, adipose thermogenesis, and tumor progression. By selectively removing ubiquitin moieties from pivotal substrates, USP17L26 could serve as an integrative hub—balancing cell cycle progression, apoptosis, and differentiation—in diverse biological systems and disease conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Howard J Goldberg, Tamás Huszár, Miklós M Mózes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the type II transforming growth factor-beta receptor inhibits fibroblasts proliferation and activates extracellular signal regulated kinase and c-Jun N-terminal kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/cbir.2001.0832"}], "href": "https://doi.org/10.1006/cbir.2001.0832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11846446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11846446"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Wang, Rui Ma, Richard A Flavell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208573200"}], "href": "https://doi.org/10.1074/jbc.M208573200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12374793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12374793"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Monique C A Duyndam, Saskia T M Hulscher, Elsken van der Wall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206320200"}], "href": "https://doi.org/10.1074/jbc.M206320200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482858"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lin Wang, Joon Hyeok Kwak, Sung Il Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403758200"}], "href": "https://doi.org/10.1074/jbc.M403758200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15143069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15143069"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guo Fu, Odilia L C Wijburg, Paul U Cameron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salmonella enterica Serovar Typhimurium infection of dendritic cells leads to functionally increased expression of the macrophage-derived chemokine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.73.3.1714-1722.2005"}], "href": "https://doi.org/10.1128/IAI.73.3.1714-1722.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15731072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15731072"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hormas Ghadially, Xiao-Lan Ross, Claudia Kerst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of CCL22 gene expression in murine dendritic cells and B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.9.5620"}], "href": "https://doi.org/10.4049/jimmunol.174.9.5620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15843561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15843561"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sung-Jo Kim, Zhongjian Zhang, Emiko Hitomi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddl105"}], "href": "https://doi.org/10.1093/hmg/ddl105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16644870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16644870"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eliane Shizuka Nakamura, Keiichi Koizumi, Mitsuo Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-006-9006-1"}], "href": "https://doi.org/10.1007/s10585-006-9006-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16821125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16821125"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mayumi Kusumoto, Baohui Xu, Minyi Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Interferon Cytokine Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/jir.2006.0064"}], "href": "https://doi.org/10.1089/jir.2006.0064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18052724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18052724"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A Dusty Miller, Ulla Bergholz, Marion Ziegler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the myelin protein plasmolipin as the cell entry receptor for Mus caroli endogenous retrovirus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00397-08"}], "href": "https://doi.org/10.1128/JVI.00397-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18463156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18463156"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maki Watanabe, Takahiro Satoh, Yoshihiro Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.8.5653"}], "href": "https://doi.org/10.4049/jimmunol.181.8.5653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18832724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18832724"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Grzegorz Sumara, Ivan Formentini, Stephan Collins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.11.018"}], "href": "https://doi.org/10.1016/j.cell.2008.11.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19135240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19135240"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Adam W Mailloux, M Rita I Young "}, {"type": "b", "children": [{"type": "t", "text": "NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0801124"}], "href": "https://doi.org/10.4049/jimmunol.0801124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19234170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19234170"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Eva M Schindler, Anna Hindes, Erin L Gribben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-4455"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-4455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19458068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19458068"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Samujjwal Chakraborty, Baobin Kang, Faqing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Differentiation (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.diff.2009.05.006"}], "href": "https://doi.org/10.1016/j.diff.2009.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19539422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19539422"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Toshiharu Onodera, Myoung Ho Jang, Zijin Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0804116"}], "href": "https://doi.org/10.4049/jimmunol.0804116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19843945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19843945"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Gerard M Gibbs, Jennifer Chi Yi Lo, Brett Nixon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2009-1255"}], "href": "https://doi.org/10.1210/en.2009-1255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20219979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20219979"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rukiye-Nazan E Dogan, Nancy Long, Eileen Forde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0810442"}], "href": "https://doi.org/10.1189/jlb.0810442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20940325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20940325"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Olivia Osborn, Manuel Sanchez-Alavez, Jeffrey S Dubins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2010.11.017"}], "href": "https://doi.org/10.1016/j.cyto.2010.11.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21177120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21177120"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Louise L Lilleholt, Claus Johansen, J Simon Arthur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Derm Venereol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2340/00015555-1046"}], "href": "https://doi.org/10.2340/00015555-1046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21336470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21336470"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "M Isabel Cerezo-Guisado, Paloma del Reino, Gaëlle Remy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of p38γ and p38δ involvement in cell transformation processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgr079"}], "href": "https://doi.org/10.1093/carcin/bgr079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21558321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21558321"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Joel Montane, Loraine Bischoff, Galina Soukhatcheva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI43048"}], "href": "https://doi.org/10.1172/JCI43048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21737880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21737880"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ana Risco, Carlos del Fresno, Agnes Mambol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1207290109"}], "href": "https://doi.org/10.1073/pnas.1207290109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22733747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22733747"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Annalisa Cavallini, Suzanne Brewerton, Amanda Bell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.463984"}], "href": "https://doi.org/10.1074/jbc.M113.463984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23798682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23798682"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Gabriel Criado, Ana Risco, Dayanira Alsina-Beauchamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative p38 MAPKs are essential for collagen-induced arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheumatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.38327"}], "href": "https://doi.org/10.1002/art.38327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24782184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24782184"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Paloma Del Reino, Dayanira Alsina-Beauchamp, Alejandra Escós, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-0870"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-0870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217523"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Liang Cao, Xiang Hu, Jian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the CCL22-CCR4 axis in the metastasis of gastric cancer cells into omental milky spots."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-014-0267-1"}], "href": "https://doi.org/10.1186/s12967-014-0267-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25245466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25245466"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ana Claudia Araujo-Pires, Andreia Espindola Vieira, Carolina Favaro Francisconi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2376"}], "href": "https://doi.org/10.1002/jbmr.2376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25264308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25264308"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jonathan M Eby, Hee-Kap Kang, Sean T Tully, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2015.26"}], "href": "https://doi.org/10.1038/jid.2015.26"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25634358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25634358"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Alejo E Rodríguez-Fraticelli, Jennifer Bagwell, Minerva Bosch-Fortea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3106"}], "href": "https://doi.org/10.1038/ncb3106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25706235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25706235"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Loraine Bischoff, Sigrid Alvarez, Derek L Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1400567"}], "href": "https://doi.org/10.4049/jimmunol.1400567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25740943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25740943"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Bárbara González-Terán, Juan Antonio López, Elena Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10477"}], "href": "https://doi.org/10.1038/ncomms10477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26795633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26795633"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Bárbara González-Terán, Nuria Matesanz, Ivana Nikolic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201591857"}], "href": "https://doi.org/10.15252/embj.201591857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26843485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26843485"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.11714"}], "href": "https://doi.org/10.21873/anticanres.11714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28668835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28668835"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "M Wada, D Canals, M Adada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.274"}], "href": "https://doi.org/10.1038/onc.2017.274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28783172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28783172"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Nuria Matesanz, Ivana Nikolic, Magdalena Leiva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38α blocks brown adipose tissue thermogenesis through p38δ inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.2004455"}], "href": "https://doi.org/10.1371/journal.pbio.2004455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29979672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29979672"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Moritz Rapp, Maximilian W M Wintergerst, Wolfgang G Kunz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20170277"}], "href": "https://doi.org/10.1084/jem.20170277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30910796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30910796"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Ignazio Piseddu, Natascha Röhrle, Maximilian Martin Ludwig Knott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2000004"}], "href": "https://doi.org/10.4049/jimmunol.2000004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32907996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32907996"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Bo Liu, Yihan Lin, Jiacong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Affinity-coupled CCL22 promotes positive selection in germinal centres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-021-03239-2"}], "href": "https://doi.org/10.1038/s41586-021-03239-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33597749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33597749"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Ayelén M Santamans, Valle Montalvo-Romeral, Alfonso Mora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.3001447"}], "href": "https://doi.org/10.1371/journal.pbio.3001447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34758018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34758018"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Elizabeth N Rudzki, Stephanie E Ander, Rachel S Coombs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toxoplasma gondii "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "GRA28"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.01591-21"}], "href": "https://doi.org/10.1128/mBio.01591-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34781732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34781732"}]}]}]}
|
| NCBI Gene ID | 728379 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
USP17L26 has 272 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.
Click the + buttons to view associations for USP17L26 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of USP17L26 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of USP17L26 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing USP17L26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with USP17L26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with USP17L26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with USP17L26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with USP17L26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of USP17L26 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of USP17L26 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of USP17L26 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with USP17L26 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |