{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVasohibin‐1 (VASH1) is an endothelium‐derived, VEGF‐inducible negative feedback regulator of angiogenesis. In response to pro‐angiogenic stimuli such as VEGF and fibroblast growth factor‐2, vascular endothelial cells upregulate VASH1 to restrict their own proliferation, migration, and neovessel formation. This autocrine negative regulation is essential for maintaining vascular homeostasis under both physiological and pathological conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cancer setting, VASH1 modulates tumor vascularization and metastatic spread by normalizing aberrant vessels and inhibiting lymphangiogenesis. Studies in diverse malignancies—including non‐small cell lung, breast, colorectal, ovarian, hepatocellular, and renal carcinomas—have revealed that altered VASH1 expression correlates with changes in intratumoral angiogenesis, vessel maturation, tumor hypoxia, and ultimately, clinical outcome. In many models, gene transfer of VASH1 or its modulation by microRNAs has been shown to suppress tumor growth, reduce lymphatic dissemination, and even enhance the efficacy of conventional chemotherapy, thereby positioning VASH1 as both a prognostic biomarker and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical anti‐angiogenic role, VASH1 functions as a tubulin detyrosinating enzyme when complexed with small vasohibin‐binding protein (SVBP). Structural and biochemical investigations have demonstrated that the VASH1–SVBP complex catalyzes the removal of the C‐terminal tyrosine residue from α‐tubulin, thereby modulating microtubule dynamics, spindle assembly during mitosis, receptor trafficking (including that of VEGF receptor 2), and even aspects of neuronal development. These cytoskeletal modifications create an additional layer by which VASH1 influences angiogenic signaling and cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, VASH1 expression and activity are regulated by a multitude of mechanisms. Its levels can be modulated by hypoxia, inflammatory cytokines, and microRNAs (for example, miR‐221–3p and miR‐22–3p), while its post‐translational processing through proteolytic cleavage and alternative splicing generates isoforms with distinct effects on vessel pruning versus normalization. These regulatory processes also influence VASH1’s role in endothelial stress tolerance, cellular senescence, hematopoietic cell proliferation, and vascular remodeling in diverse settings such as diabetic nephropathy, portal hypertension, arthritis, and placental development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "32", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kazuhide Watanabe, Yasuhiro Hasegawa, Hiroshi Yamashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI21152"}], "href": "https://doi.org/10.1172/JCI21152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15467828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15467828"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasufumi Sato "}, {"type": "b", "children": [{"type": "t", "text": "The vasohibin family: a novel family for angiogenesis regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvs128"}], "href": "https://doi.org/10.1093/jb/mvs128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23100270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23100270"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Johann Kern, Michael Steurer, Günther Gastl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-9-284"}], "href": "https://doi.org/10.1186/1471-2407-9-284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19682397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19682397"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chen-Fei Zhou, Jing Ma, Lei Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0511-x"}], "href": "https://doi.org/10.1038/s41388-018-0511-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30254211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30254211"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tomoko Hosaka, Hiroshi Kimura, Takahiro Heishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080788"}], "href": "https://doi.org/10.2353/ajpath.2009.080788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498005"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kentaro Tamaki, Takuya Moriya, Yasufumi Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 in human breast carcinoma: a potential negative feedback regulator of angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2008.01015.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2008.01015.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19037993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19037993"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takahiro Heishi, Tomoko Hosaka, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2010.090829"}], "href": "https://doi.org/10.2353/ajpath.2010.090829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20133819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20133819"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Laura Coch, Marc Mejias, Annalisa Berzigotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26995"}], "href": "https://doi.org/10.1002/hep.26995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24390792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24390792"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "T Kosaka, Y Miyazaki, A Miyajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic significance of vasohibin-1 expression in patients with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2013.169"}], "href": "https://doi.org/10.1038/bjc.2013.169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23591203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23591203"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yasumasa Miyazaki, Takeo Kosaka, Shuji Mikami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-12-0073"}], "href": "https://doi.org/10.1158/1078-0432.CCR-12-0073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22675166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22675166"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Keigo Murakami, Atsuko Kasajima, Naoki Kawagishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic significance of vasohibin 1-associated angiogenesis in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2013.10.028"}], "href": "https://doi.org/10.1016/j.humpath.2013.10.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24444468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24444468"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qizhi Wang, Xiangguo Tian, Chunqing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of vasohibin-1 expression with angiogenesis and poor prognosis of hepatocellular carcinoma after curative surgery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-011-0106-7"}], "href": "https://doi.org/10.1007/s12032-011-0106-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22101788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22101788"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tao Zhang, Ting-Ting Yu, Dong-Ming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 expression detected by immunohistochemistry correlates with prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0963-y"}], "href": "https://doi.org/10.1007/s12032-014-0963-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24748406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24748406"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Guangning Zhao, Yuming Yang, Yang Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of vasohibin-1 is associated with clinicopathological features in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0313-x"}], "href": "https://doi.org/10.1007/s12032-012-0313-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22865127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22865127"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Naoki Kanomata, Yasufumi Sato, Yoshiyuki Miyaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 is a new predictor of disease-free survival in operated patients with renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jclinpath-2013-201444"}], "href": "https://doi.org/10.1136/jclinpath-2013-201444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23543668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23543668"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shuai Liu, Bing Han, Qunyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 suppresses colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3493"}], "href": "https://doi.org/10.18632/oncotarget.3493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25797264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25797264"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yoshifumi Takahashi, Yasushi Saga, Takahiro Koyanagi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3193"}], "href": "https://doi.org/10.3892/ijo.2015.3193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26460696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26460696"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kohei Miyake, Keiichiro Nishida, Yasutaka Kadota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammatory cytokine-induced expression of vasohibin-1 by rheumatoid synovial fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Med Okayama (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18926/AMO/31820"}], "href": "https://doi.org/10.18926/AMO/31820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20035291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20035291"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Takahito Kitajima, Yuji Toiyama, Koji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 increases the malignant potential of colorectal cancer and is a biomarker of poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25275025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25275025"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shuji Mikami, Mototsugu Oya, Takeo Kosaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2017.26"}], "href": "https://doi.org/10.1038/labinvest.2017.26"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28287633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28287633"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yoshifumi Takahashi, Yasushi Saga, Takahiro Koyanagi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 expression inhibits advancement of ovarian cancer producing various angiogenic factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12911"}], "href": "https://doi.org/10.1111/cas.12911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26893100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26893100"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Joppe Nieuwenhuis, Athanassios Adamopoulos, Onno B Bleijerveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibins encode tubulin detyrosinating activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aao5676"}], "href": "https://doi.org/10.1126/science.aao5676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29146869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29146869"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Joppe Nieuwenhuis, Thijn R Brummelkamp "}, {"type": "b", "children": [{"type": "t", "text": "The Tubulin Detyrosination Cycle: Function and Enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tcb.2018.08.003"}], "href": "https://doi.org/10.1016/j.tcb.2018.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30213517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30213517"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Faxiang Li, Yingjie Hu, Shutao Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of tubulin detyrosination by vasohibins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0242-x"}], "href": "https://doi.org/10.1038/s41594-019-0242-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235910"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hikaru Sonoda, Hideki Ohta, Kazuhide Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.01.185"}], "href": "https://doi.org/10.1016/j.bbrc.2006.01.185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16488400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16488400"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Na Wang, Christophe Bosc, Sung Ryul Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0241-y"}], "href": "https://doi.org/10.1038/s41594-019-0241-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235911"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Athanassios Adamopoulos, Lisa Landskron, Tatjana Heidebrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0254-6"}], "href": "https://doi.org/10.1038/s41594-019-0254-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270470"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Miho Kobayashi, Ikumi Wakabayashi, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-020-09754-6"}], "href": "https://doi.org/10.1007/s10456-020-09754-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33052495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33052495"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Tomohiro Kozako, Noriko Matsumoto, Yukako Kuramoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.03.007"}], "href": "https://doi.org/10.1016/j.febslet.2012.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22569265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22569265"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Lin Li, Preston Williams, Zi Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa1092"}], "href": "https://doi.org/10.1093/nar/gkaa1092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33231681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33231681"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "S Horie, Y Suzuki, M Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cgt.2016.13"}], "href": "https://doi.org/10.1038/cgt.2016.13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27080222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27080222"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Tatsuyo Nasu, Yohei Maeshima, Masaru Kinomura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db08-1790"}], "href": "https://doi.org/10.2337/db08-1790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19587360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19587360"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Zhanlong Shen, Tuuli Kauttu, Hanna Seppänen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0212-1"}], "href": "https://doi.org/10.1007/s12032-012-0212-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438034"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Christina Yingxian Chen, Alexander K Salomon, Matthew A Caporizzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.119.315947"}], "href": "https://doi.org/10.1161/CIRCRESAHA.119.315947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32272864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32272864"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Eichi Takeda, Yasuhiro Suzuki, Yasufumi Sato "}, {"type": "b", "children": [{"type": "t", "text": "Age-associated downregulation of vasohibin-1 in vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12497"}], "href": "https://doi.org/10.1111/acel.12497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27325558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27325558"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Clara Sm Tang, Xuehan Zhuang, Wai-Yee Lam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-018-0129-z"}], "href": "https://doi.org/10.1038/s41431-018-0129-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29483666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29483666"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Luz Consuelo Zepeda-Romero, Miguel Vazquez-Membrillo, Elva Adan-Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Higher prolactin and vasoinhibin serum levels associated with incidence and progression of retinopathy of prematurity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/pr.2016.241"}], "href": "https://doi.org/10.1038/pr.2016.241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27842054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27842054"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Zhanlong Shen, Hanna Seppänen, Tuuli Kauttu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 expression is regulated by transforming growth factor-β/bone morphogenic protein signaling pathway between tumor-associated macrophages and pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Interferon Cytokine Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/jir.2012.0046"}], "href": "https://doi.org/10.1089/jir.2012.0046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23651239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23651239"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Muna Affara, Debbie Sanders, Hiromitsu Araki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-14-23"}], "href": "https://doi.org/10.1186/1471-2164-14-23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23324451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23324451"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Hisamichi Naito, Hiroyasu Kidoya, Yasufumi Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvp021"}], "href": "https://doi.org/10.1093/jb/mvp021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19179360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19179360"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Georgina Ortiz, Maria G Ledesma-Colunga, Zhijian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41374-020-0432-5"}], "href": "https://doi.org/10.1038/s41374-020-0432-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32341517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32341517"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Kaori Suenaga, Shuji Kitahara, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0104728"}], "href": "https://doi.org/10.1371/journal.pone.0104728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25184477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25184477"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Megumu Saito, Yasuhiro Suzuki, Seiji Yano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvw030"}], "href": "https://doi.org/10.1093/jb/mvw030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27169581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27169581"}]}]}]}