{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVasohibin‐2 (VASH2), a homolog of the angiogenesis inhibitor VASH1, has emerged as a multifunctional protein with both enzymatic and signaling roles. Structural and biochemical investigations have revealed that VASH2 forms a complex with the small vasohibin‐binding protein (SVBP) to act as a tubulin carboxypeptidase—catalyzing the removal of the C‑terminal tyrosine from α‑tubulin, thereby modulating microtubule dynamics and influencing processes such as neuronal axon specification. In addition, differential isoforms of VASH2 exhibit distinct subcellular localizations, with cytoplasmic forms contributing to its catalytic and secretory functions and nuclear forms promoting cell cycle progression. These findings highlight an unconventional secretion mechanism and a unique domain architecture that underpin its versatile role in cellular physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncological setting, VASH2 functions predominantly as a pro‐tumorigenic factor. It is frequently overexpressed in a wide spectrum of malignancies—including hepatocellular carcinoma, ovarian, gastric, pancreatic, non‐small cell lung, breast, and even pediatric medulloblastoma—and promotes tumor progression by enhancing angiogenesis, cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT). VASH2 drives these processes through multiple mechanisms such as the paracrine secretion of proangiogenic factors (e.g., fibroblast growth factor 2 and vascular endothelial growth factor), transcriptional modulation via histone modifications, and the activation of key signaling pathways like TGF‑β and AKT. This multifaceted action not only stimulates the formation of new blood vessels but also contributes to chemoresistance by upregulating drug efflux proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, VASH2 is implicated in several non‐neoplastic pathologies. It plays a part in normal placental development by regulating trophoblast fusion for syncytiotrophoblast formation, while its aberrant expression is linked to vascular alterations in diseases such as atherosclerosis, renal dysfunction, and proliferative diabetic retinopathy. Moreover, increased VASH2 levels have been observed in conditions like lymphangioleiomyomatosis and peripheral artery disease, where its impact on tubulin detyrosination may affect vascular smooth muscle cell behavior and arterial elasticity. These diverse roles underscore the broad physiological and pathophysiological impact of VASH2, positioning it as a promising therapeutic target in both tumor and non‐tumor settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasufumi Sato "}, {"type": "b", "children": [{"type": "t", "text": "The vasohibin family: a novel family for angiogenesis regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvs128"}], "href": "https://doi.org/10.1093/jb/mvs128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23100270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23100270"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Sun, Min Tu, Bei Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation and characterization of rabbit polyclonal antibodies against Vasohibin-2 for determination of its intracellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.1919"}], "href": "https://doi.org/10.3892/ijo.2013.1919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23615928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23615928"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qianqian Ge, Jia Zhou, Min Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear vasohibin-2 promotes cell proliferation by inducing G0/G1 to S phase progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4127"}], "href": "https://doi.org/10.3892/or.2015.4127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26177649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26177649"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tetsuya Kadonosono, Wanaporn Yimchuen, Takuya Tsubaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.3089"}], "href": "https://doi.org/10.1002/pro.3089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27879017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27879017"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Joppe Nieuwenhuis, Athanassios Adamopoulos, Onno B Bleijerveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibins encode tubulin detyrosinating activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aao5676"}], "href": "https://doi.org/10.1126/science.aao5676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29146869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29146869"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Na Wang, Christophe Bosc, Sung Ryul Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-019-0241-y"}], "href": "https://doi.org/10.1038/s41594-019-0241-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235911"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhanlong Shen, Tuuli Kauttu, Hanna Seppänen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0212-1"}], "href": "https://doi.org/10.1007/s12032-012-0212-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438034"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "X Xue, W Gao, B Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.177"}], "href": "https://doi.org/10.1038/onc.2012.177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22614011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22614011"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yoshifumi Takahashi, Takahiro Koyanagi, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-12-0098-T"}], "href": "https://doi.org/10.1158/1541-7786.MCR-12-0098-T"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22826464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22826464"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaofeng Xue, Ye Zhang, Qiaoming Zhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR200-upregulated Vasohibin 2 promotes the malignant transformation of tumors by inducing epithelial-mesenchymal transition in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-014-0062-x"}], "href": "https://doi.org/10.1186/s12964-014-0062-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25269476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25269476"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jung-Chul Kim, Kyung-Tae Kim, Jong-Tae Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of vasohibin-2 in pancreatic ductal adenocarcinoma promotes tumor progression and is associated with a poor clinical outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatogastroenterology (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25916042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25916042"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Min Tu, Cheng Lu, Nan Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin 2 promotes human luminal breast cancer angiogenesis in a non-paracrine manner via transcriptional activation of fibroblast growth factor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.09.031"}], "href": "https://doi.org/10.1016/j.canlet.2016.09.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27702660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27702660"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rie Norita, Yasuhiro Suzuki, Yutaka Furutani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13157"}], "href": "https://doi.org/10.1111/cas.13157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28064471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28064471"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Min Tu, Haifeng Li, Nan Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0619-6"}], "href": "https://doi.org/10.1186/s12943-017-0619-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28327155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28327155"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yasuhiro Suzuki, Shuji Kitahara, Takuya Suematsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13411"}], "href": "https://doi.org/10.1111/cas.13411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28960674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28960674"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Deliang Ma, Liang Wu, Shuangjie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin2 promotes adriamycin resistance of breast cancer cells through regulating ABCG2 via AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7792"}], "href": "https://doi.org/10.3892/mmr.2017.7792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29039601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29039601"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ye Zhang, Xiaofeng Xue, Xiaoqian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin 2 promotes malignant behaviors of pancreatic cancer cells by inducing epithelial-mesenchymal transition via Hedgehog signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1752"}], "href": "https://doi.org/10.1002/cam4.1752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30318866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30318866"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiangbin Tan, Zefei Liao, Shuangyou Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VASH2 Promotes Cell Proliferation and Resistance to Doxorubicin in Non-Small Cell Lung Cancer via AKT Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504019X15509383469698"}], "href": "https://doi.org/10.3727/096504019X15509383469698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30940294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30940294"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Rie Iida-Norita, Minaho Kawamura, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-2 plays an essential role in metastasis of pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14041"}], "href": "https://doi.org/10.1111/cas.14041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31074083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31074083"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hitoshi Hara, Soji Ozawa, Yamato Ninomiya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of vasohibin-1 and vasohibin-2 immunohistochemical expression in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surg Today (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00595-020-02040-4"}], "href": "https://doi.org/10.1007/s00595-020-02040-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32494966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32494966"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J Wang, C Yu, X Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Vasohibin-2 promotes proliferation and metastasis of cervical cancer cells by regulating epithelial-mesenchymal transition]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2022.07.02"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2022.07.02"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35869758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35869758"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wen Liu, Yinan Fu, Meng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A preliminary study on the mechanism of VASH2 in childhood medulloblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-42869-6"}], "href": "https://doi.org/10.1038/s41598-023-42869-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37821528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37821528"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Kaori Suenaga, Shuji Kitahara, Yasuhiro Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0104728"}], "href": "https://doi.org/10.1371/journal.pone.0104728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25184477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25184477"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yuka Arata, Katsuyuki Tanabe, Norikazu Hinamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemistry of Vasohibin-2 in Human Kidney Disease : Implications in Impaired Glucose Tolerance and Reduced Renal Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Med Okayama (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18926/AMO/55434"}], "href": "https://doi.org/10.18926/AMO/55434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29042694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29042694"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Chihiro Inoue, Yasuhiro Miki, Ryoko Saito-Koyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vasohibin-1 and -2 in pulmonary lymphangioleiomyomatosis (LAM) cells associated with angiogenic and prognostic factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.153758"}], "href": "https://doi.org/10.1016/j.prp.2022.153758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35026646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35026646"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ryutaro Isoda, Ichiro Morita, Atsuhisa Ishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathological Study on the Expression of Vasohibins in Peripheral Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tohoku J Exp Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1620/tjem.2022.J063"}], "href": "https://doi.org/10.1620/tjem.2022.J063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35922907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35922907"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yuzhi Ding, Na Su, Jie Luan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Vasohibin-2 expression correlated with autophagy in proliferative diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Eye Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exer.2024.109808"}], "href": "https://doi.org/10.1016/j.exer.2024.109808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38278467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38278467"}]}]}]}