{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVAV2 is a ubiquitously expressed guanine nucleotide exchange factor (GEF) for Rho family GTPases that plays a critical role in cytoskeletal remodeling. Early studies established that activated VAV2 promotes Rac1 activation, thereby enhancing integrin‐mediated cell adhesion, membrane ruffling, and lamellipodia formation. Its regulatory function is dependent on specific structural domains—including the pleckstrin homology (PH) and cysteine‐rich (CRD) regions—and is subject to Src‐dependent phosphorylation events that facilitate its recruitment to membrane protrusions and sites of active signal transduction (["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nVAV2 also functions as an integral downstream effector in growth factor and immune receptor signaling pathways. It becomes tyrosine phosphorylated in response to oncogenic Src and receptor activation, thereby linking signals from epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR‐2), and the B‐cell receptor to Rac1 activation. This modulation is key for processes such as cell spreading, endothelial migration and vascular remodeling, as well as for coupling antigen receptor signals to gene activation (["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells, VAV2 contributes to a more aggressive phenotype by orchestrating cytoskeletal reorganization that drives cell migration, invasion, and metastasis. It is required for the maturation of invasive structures such as invadopodia—through interactions with phosphorylated cortactin and regulators like p120‐catenin—and cooperates with its family members to sustain transcriptional programs linked to tumor growth and metastasis. These activities underline a central role for VAV2 in modulating Rho/Rac signaling pathways that control both cell motility and invasiveness in diverse tumor types (["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "]).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in Rac1 activation and cytoskeletal dynamics, VAV2 exerts multiple functions in diverse physiological and pathological contexts. It has been implicated in neuronal development and neurite outgrowth, regulation of insulin secretion, and modulation of DNA repair pathways that contribute to radioresistance. VAV2 also influences ribosome biogenesis and smooth muscle cell migration—processes that are key to tissue remodeling in the vasculature and pathologies like patent ductus arteriosus. Moreover, VAV2’s activity is finely tuned by its interactions with lipid membranes, viral proteins, and adaptor molecules (for example, binding phosphorylated motifs in partners such as Arap3), and genetic studies have linked variants in VAV2 to human diseases such as glaucoma, multiple sclerosis, and cardiovascular dysfunction. Collectively, these findings underscore the multifaceted role of VAV2 in transducing signals from cell surface receptors to downstream effectors across a range of normal and disease states ([."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P A Marignani, C L Carpenter "}, {"type": "b", "children": [{"type": "t", "text": "Vav2 is required for cell spreading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200103134"}], "href": "https://doi.org/10.1083/jcb.200103134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11448999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11448999"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michelle A Booden, Sharon L Campbell, Channing J Der "}, {"type": "b", "children": [{"type": "t", "text": "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.8.2487-2497.2002"}], "href": "https://doi.org/10.1128/MCB.22.8.2487-2497.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11909943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11909943"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "William T Arthur, Lawrence A Quilliam, Jonathan A Cooper "}, {"type": "b", "children": [{"type": "t", "text": "Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200404068"}], "href": "https://doi.org/10.1083/jcb.200404068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15479739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15479739"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jongyun Heo, Roopa Thapar, Sharon L Campbell "}, {"type": "b", "children": [{"type": "t", "text": "Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi047443q"}], "href": "https://doi.org/10.1021/bi047443q"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15850391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15850391"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Joan-Marc Servitja, Maria Julia Marinissen, Akrit Sodhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302960200"}], "href": "https://doi.org/10.1074/jbc.M302960200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12810717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12810717"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Isabelle Foucault, Séverine Le Bras, Céline Charvet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-08-2965"}], "href": "https://doi.org/10.1182/blood-2003-08-2965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15345594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15345594"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tiana A Garrett, Jaap D Van Buul, Keith Burridge "}, {"type": "b", "children": [{"type": "t", "text": "VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2007.05.027"}], "href": "https://doi.org/10.1016/j.yexcr.2007.05.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17686471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17686471"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "S Thalappilly, P Soubeyran, J L Iovanna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAV2 regulates epidermal growth factor receptor endocytosis and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.1"}], "href": "https://doi.org/10.1038/onc.2010.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20140013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20140013"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "L S Havel, E R Kline, A M Salgueiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.123"}], "href": "https://doi.org/10.1038/onc.2014.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24858039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24858039"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Vyomesh Patel, Hans M Rosenfeldt, Ruth Lyons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgm008"}], "href": "https://doi.org/10.1093/carcin/bgm008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17234718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17234718"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Laura Barrio-Real, Marcelo G Kazanietz "}, {"type": "b", "children": [{"type": "t", "text": "Rho GEFs and cancer: linking gene expression and metastatic dissemination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2003543"}], "href": "https://doi.org/10.1126/scisignal.2003543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23033535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23033535"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Carmen Citterio, Mauricio Menacho-Márquez, Ramón García-Escudero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2002962"}], "href": "https://doi.org/10.1126/scisignal.2002962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23033540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23033540"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Gabriela Valls, Montserrat Codina, Rachel K Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.101030"}], "href": "https://doi.org/10.1242/jcs.101030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22946057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22946057"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chien-Yu Cho, Kuo-Ting Lee, Wei-Ching Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7542"}], "href": "https://doi.org/10.18632/oncotarget.7542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26910843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26910843"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Brian J Rosenberg, Hava Gil-Henn, Christopher C Mader, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E16-12-0885"}], "href": "https://doi.org/10.1091/mbc.E16-12-0885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28356423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28356423"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kirsten Holthusen, Ana M Gonzalez, Patricio I Meneses "}, {"type": "b", "children": [{"type": "t", "text": "Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ther (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MJT.0b013e31819be0a5"}], "href": "https://doi.org/10.1097/MJT.0b013e31819be0a5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19451809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19451809"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Myung-soon Moon, Timothy M Gomez "}, {"type": "b", "children": [{"type": "t", "text": "Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2010.03.001"}], "href": "https://doi.org/10.1016/j.mcn.2010.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20298788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20298788"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kollu N Rao, Inderjeet Kaur, Rajul S Parikh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.10-5553"}], "href": "https://doi.org/10.1167/iovs.10-5553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20463313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20463313"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sandra Nischwitz, Sabine Cepok, Antje Kroner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2010.06.003"}], "href": "https://doi.org/10.1016/j.jneuroim.2010.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20598377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20598377"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jan Peter Boettcher, Marieluise Kirchner, Yuri Churin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1000457"}], "href": "https://doi.org/10.1371/journal.pbio.1000457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20808760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20808760"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Alexander Emami-Nemini, Antje Gohla, Henning Urlaub, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.112.078824"}], "href": "https://doi.org/10.1124/mol.112.078824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22554804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22554804"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Bo Wu, Fengsong Wang, Jiahai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and structural basis for a novel interaction between Vav2 and Arap3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsb.2012.06.011"}], "href": "https://doi.org/10.1016/j.jsb.2012.06.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22750419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22750419"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Dong Shi, Yoshimasa Takano, Toru Nakazawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.02.003"}], "href": "https://doi.org/10.1016/j.bbrc.2013.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23402756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23402756"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Adèle Salin-Cantegrel, Masoud Shekarabi, Sarah Rasheed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0065294"}], "href": "https://doi.org/10.1371/journal.pone.0065294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23724134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23724134"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Rajakrishnan Veluthakal, Ragadeepthi Tunduguru, Daleep Kumar Arora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-015-3707-4"}], "href": "https://doi.org/10.1007/s00125-015-3707-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26224100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26224100"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Shasha Liu, Xue Wu, Minru Zong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for a novel interaction between TXNIP and Vav2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12110"}], "href": "https://doi.org/10.1002/1873-3468.12110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26919541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26919541"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Carmen Ruggiero, Mabrouka Doghman-Bouguerra, Silviu Sbiera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dosage-dependent regulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VAV2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aal2464"}], "href": "https://doi.org/10.1126/scisignal.aal2464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28270555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28270555"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xizhe Li, Jiali Zhu, Yuanqi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-331-3p inhibits epithelial-mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/β-catenin axis in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14014"}], "href": "https://doi.org/10.1111/cas.14014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30955235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30955235"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "P Wang, G-Z Liu, J-F Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG3 silencing suppresses the malignant development of triple-negative breast cancer cells by regulating miRNA-326/integrin α5 axis and inactivating Vav2/Rac1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21333"}], "href": "https://doi.org/10.26355/eurrev_202005_21333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495883"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "L Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18524-3"}], "href": "https://doi.org/10.1038/s41467-020-18524-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32963234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32963234"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Weiling Liu, Chuanwang Miao, Shaosen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-021-00735-9"}], "href": "https://doi.org/10.1038/s41392-021-00735-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34462423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34462423"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yushun Bai, Ji Zheng, Lei Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potentially functional genetic variants of VAV2 and PSMA4 in the immune-activation pathway and non-small cell lung cancer survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3447"}], "href": "https://doi.org/10.1002/jgm.3447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36039727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36039727"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jian Ren, Xiaoling Wu, Fei-Fei Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/8708312"}], "href": "https://doi.org/10.1155/2022/8708312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36426134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36426134"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Bo Sun, Bai Ding, Yu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-023-03871-8"}], "href": "https://doi.org/10.1186/s12967-023-03871-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36631800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36631800"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yinghui Chen, Yizhuo Wu, Weiqi Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-023-02377-6"}], "href": "https://doi.org/10.1007/s00109-023-02377-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37804474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37804474"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Natalia Fernández-Parejo, L Francisco Lorenzo-Martín, Juana M García-Pedrero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-54808-0"}], "href": "https://doi.org/10.1038/s41598-024-54808-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38374399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38374399"}]}]}]}