{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVCAN-AS1 is emerging as a critical oncogenic long noncoding RNA in multiple cancer types. In gastric cancer, VCAN-AS1 is significantly overexpressed in tumor tissues and cell lines relative to normal gastric tissues, with its increased expression being associated with poor patient prognosis. Functional assays demonstrate that silencing VCAN-AS1 suppresses cell proliferation, migration, and invasion, while promoting apoptosis. Mechanistically, VCAN-AS1 exerts its oncogenic role by binding to eIF4A3, a core component of the exon junction complex, thereby negatively regulating wild-type p53 levels and facilitating tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in breast cancer, VCAN-AS1 is upregulated and correlates with unfavorable overall survival. Here, VCAN-AS1 drives malignancy by functioning as a competitive endogenous RNA (ceRNA) for miR-106a-5p, leading to the derepression of STAT3, which in turn activates the HIF-1α signaling pathway. This regulation promotes breast cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), while inhibiting apoptosis. Collectively, these findings highlight VCAN-AS1 as a multifunctional oncogenic lncRNA that contributes to cancer progression through distinct molecular mechanisms in different tumor contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Feng, Jian Li, Fan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA VCAN-AS1 contributes to the progression of gastric cancer via regulating p53 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29315"}], "href": "https://doi.org/10.1002/jcp.29315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31637706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31637706"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peng Du, Kaifeng Luo, Guoyong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3/HIF-1α pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1960774"}], "href": "https://doi.org/10.1080/21655979.2021.1960774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34365889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34365889"}]}]}]}