| HGNC Family | Homeoboxes |
| Name | VENT homeobox pseudogene 1 |
| Description | Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the Vent homeobox gene family. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have established key roles for various regulatory factors in controlling cell motility, differentiation, and apoptosis. For example, CD164 has been shown to regulate myoblast migration and fusion during muscle development and regeneration, emphasizing the importance of controlled cell–cell interactions ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In parallel, proteins from the MSSP family have been implicated in DNA replication and transcription as well as in the regulation of apoptosis via modulation of target genes such as c‐myc and Fas ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAgainst this regulatory backdrop, the long noncoding RNA VENTXP1 emerges as a distinct tumor suppressor in head and neck squamous cell carcinoma (HNSCC). Epigenetic silencing of VENTXP1 is observed in multiple cancer types, and low levels of this lncRNA correlate with poorer patient survival ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. Mechanistically, VENTXP1 directly interacts with miR-205-5p, thereby influencing the expression of ANKRD2—a key modulator of NF-κB signaling that controls cell proliferation and tumorigenicity. This interplay results in the suppression of NF-κB-mediated tumor growth, suggesting that strategies aimed at restoring VENTXP1 expression, for instance via pharmaceutical targeting of DNA methylation, might offer new therapeutic opportunities in HNSCC.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gyu-Un Bae, Ursula Gaio, Youn-Joo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706730200"}], "href": "https://doi.org/10.1074/jbc.M706730200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18227060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18227060"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M Fujimoto, K Matsumoto, S M Iguchi-Ariga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1365-2443.2001.00488.x"}], "href": "https://doi.org/10.1046/j.1365-2443.2001.00488.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11737267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11737267"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Nomura, Ken-ichi Matsumoto, Sanae M M Iguchi-Ariga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2005.01.006"}], "href": "https://doi.org/10.1016/j.yexcr.2005.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15817157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15817157"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Ming Zhang, Li Xin Su, Jing Zhou Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of VENTXP1 suppresses tumor proliferation via miR-205-5p/ANKRD2/NF-kB signaling in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03057-w"}], "href": "https://doi.org/10.1038/s41419-020-03057-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33037177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33037177"}]}]}]}
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| Synonyms | VENTX2P1, CT18 |
| Proteins | CT18_HUMAN |
| NCBI Gene ID | 139538 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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VENTXP1 has 853 functional associations with biological entities spanning 6 categories (molecular profile, organism, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.
Click the + buttons to view associations for VENTXP1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of VENTXP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of VENTXP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VENTXP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of VENTXP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of VENTXP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VENTXP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of VENTXP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VENTXP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of VENTXP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VENTXP1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VENTXP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of VENTXP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of VENTXP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of VENTXP1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of VENTXP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of VENTXP1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of VENTXP1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of VENTXP1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of VENTXP1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VENTXP1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of VENTXP1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
