VEZT Gene

Name	vezatin, adherens junctions transmembrane protein
Description	This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVezatin (VEZT) is a transmembrane protein localized at adherens junctions that plays a pivotal role in cell–cell adhesion. During early embryonic development, VEZT is expressed as early as the preimplantation stages where it co‐localizes with E‐cadherin and β‐catenin, thereby facilitating compaction and proper morphogenesis. Disruption of VEZT function during these critical stages leads to impaired junctional integrity and cell cycle arrest, underscoring its essential role in early morphogenetic events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn gastric cancer, VEZT exhibits tumor suppressor properties. Multiple studies have demonstrated that VEZT expression is significantly downregulated in neoplastic tissues relative to normal controls, primarily as a consequence of promoter hypermethylation and post‐transcriptional repression by microRNAs. Restoration of VEZT expression—whether by demethylating agents or by small activating RNA (saRNA) approaches—has been shown to inhibit cancer cell growth, invasion, and tumorigenesis by modulating downstream gene networks linked to cell cycle progression and cytoskeletal organization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "\n\nFurthermore, genetic association studies have implicated polymorphisms within the VEZT locus in the susceptibility to endometriosis. These findings, observed in diverse populations, reinforce the notion that VEZT’s function extends beyond maintaining cell adhesion, contributing also to the etiology of certain benign gynecologic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n\nRecent evidence also identifies VEZT as a modulator of neuronal synaptic transmission in epilepsy. In epileptic conditions, increased VEZT expression in the hippocampus is associated with enhanced AMPA receptor–mediated synaptic events, notably through modulation of the GluA1 subunit phosphorylation via protein kinase A. Knockdown of VEZT results in diminished GluA1 phosphorylation and a reduction in seizure activity, suggesting that VEZT-mediated signaling pathways may represent novel targets for antiepileptic therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vincent Hyenne, Sophie Louvet-Vallée, Aziz El-Amraoui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2005.09.004"}], "href": "https://doi.org/10.1016/j.ydbio.2005.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16199027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16199027"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaobo Guo, Changqing Jing, Leping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.12.026"}], "href": "https://doi.org/10.1016/j.bbrc.2010.12.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21156161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21156161"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ruizhen Miao, Xiaobo Guo, Qiaoming Zhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0074409"}], "href": "https://doi.org/10.1371/journal.pone.0074409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24069310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24069310"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Detian Xie, Liang Shang, Lipan Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of VEZT by small activating RNA inhibits the proliferation, invasion and migration of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.11.071"}], "href": "https://doi.org/10.1016/j.bbrc.2016.11.071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27856244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27856244"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yan-Sen Li, Yue-Zhi Chen, Xiao-Bo Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEZT as a novel independent prognostic factor in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-150476"}], "href": "https://doi.org/10.3233/CBM-150476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25792470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25792470"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michail Matalliotakis, Maria I Zervou, Charoula Matalliotaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of gene polymorphisms in endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7398"}], "href": "https://doi.org/10.3892/mmr.2017.7398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28901453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28901453"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Luca Pagliardini, Davide Gentilini, Ana Maria Sanchez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication and meta-analysis of previous genome-wide association studies confirm vezatin as the locus with the strongest evidence for association with endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dev022"}], "href": "https://doi.org/10.1093/humrep/dev022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25678572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25678572"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "You Wang, Jinxian Yuan, Xinyuan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04233-2"}], "href": "https://doi.org/10.1038/s41419-021-04233-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34642320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34642320"}]}]}]}
Synonyms	VEZATIN
Proteins	VEZA_HUMAN
NCBI Gene ID	55591
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VEZT has 7,374 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for VEZT from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VEZT Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VEZT gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VEZT gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VEZT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VEZT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VEZT gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VEZT gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VEZT gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VEZT gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of VEZT gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VEZT gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VEZT gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VEZT protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VEZT gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VEZT gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VEZT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VEZT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of VEZT gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VEZT gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VEZT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VEZT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing VEZT protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VEZT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VEZT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VEZT gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VEZT gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with VEZT gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of VEZT protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VEZT gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with VEZT gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VEZT gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VEZT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VEZT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VEZT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VEZT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VEZT gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VEZT gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VEZT gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VEZT from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of VEZT gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with VEZT gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.