{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular and esophageal carcinoma models, VLDLR‐AS1 (also known as linc‐VLDLR) is a long noncoding RNA that becomes enriched in extracellular vesicles released by malignant cells. Its expression is robustly upregulated in response to chemotherapeutic stress—including treatment with agents such as sorafenib, camptothecin, and doxorubicin—and it appears to contribute to chemoresistance by promoting cell cycle progression and enhancing cell viability. Mechanistically, VLDLR‐AS1 knockdown reduces cellular viability and disrupts the cell cycle, in part by decreasing the expression of key drug efflux transporters such as ABCG2, thereby potentiating chemotherapy‐induced cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to its pro-survival role in cancer cells, circulating levels of VLDLR‐AS1 are significantly lower in patients with repetitive mild traumatic brain injuries (rmTBI). This reduction is associated with a higher burden of depression symptoms, suggesting that VLDLR‐AS1 may serve as a blood-based biomarker for chronic neurological injury and depression. The evidence supporting this diagnostic potential underscores the diverse roles of VLDLR‐AS1 in both cancer stress responses and neuropsychiatric sequelae following traumatic injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kenji Takahashi, Irene K Yan, Joseph Wood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0636"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0636"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24874432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24874432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "YueTong Chen, Liang Liu, Jie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of long noncoding RNA (linc-VLDLR) existing in extracellular vesicles on the occurrence and multidrug resistance of esophageal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2018.12.033"}], "href": "https://doi.org/10.1016/j.prp.2018.12.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30606658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30606658"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rekha S Patel, Meredith Krause-Hauch, Kimbra Kenney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms25031473"}], "href": "https://doi.org/10.3390/ijms25031473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38338752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38338752"}]}]}]}